Gene Symbol: nht
Description: no hitter
Alias: BG:DS07851.6, CG15259, DS07851.6, Dmel\CG15259, Nht, TAF4, TFIID, dTAF4L, dTAF[[II]]110, dmTAF4b, no hitter, CG15259-PB, nht-PB, nohitter
Species: fruit fly

Top Publications

  1. Goodrich J, Tjian R. Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation. Nat Rev Genet. 2010;11:549-58 pubmed publisher
    ..Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions. ..
  2. Hiller M, Chen X, Pringle M, Suchorolski M, Sancak Y, Viswanathan S, et al. Testis-specific TAF homologs collaborate to control a tissue-specific transcription program. Development. 2004;131:5297-308 pubmed
    ..rye proteins interact structurally when co-expressed in bacteria, similarly to their generally expressed homologs TAF4 and TAF12, which heterodimerize...
  3. Chen X, Hiller M, Sancak Y, Fuller M. Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation. Science. 2005;310:869-72 pubmed
    ..Testis TAFs also promoted relocalization of Polycomb Repression Complex 1 components to the nucleolus in spermatocytes, implicating subnuclear architecture in the regulation of terminal differentiation. ..
  4. Jiang J, Benson E, Bausek N, Doggett K, White Cooper H. Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with always early. Development. 2007;134:1549-59 pubmed
    ..tomb and aly might be components of a complex paralogous to the Drosophila dREAM/Myb-MuvB and C. elegans DRM transcriptional regulatory complexes. ..
  5. Metcalf C, Wassarman D. Nucleolar colocalization of TAF1 and testis-specific TAFs during Drosophila spermatogenesis. Dev Dyn. 2007;236:2836-43 pubmed
    ..tTAFs are paralogs of generally expressed TAF subunits of transcription factor IID (TFIID)...
  6. Zhao J, Klyne G, Benson E, Gudmannsdottir E, White Cooper H, Shotton D. FlyTED: the Drosophila Testis Gene Expression Database. Nucleic Acids Res. 2010;38:D710-5 pubmed publisher
    ..org/software/), and provides both web-based search and browse interfaces, and programmatic access via an SQL dump, OAI-PMH and SPARQL. FlyTED is available at http://www.fly-ted.org/. ..
  7. Hochheimer A, Tjian R. Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression. Genes Dev. 2003;17:1309-20 pubmed
  8. Theofel I, Bartkuhn M, Hundertmark T, Boettger T, Gärtner S, Leser K, et al. tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family. PLoS ONE. 2014;9:e108267 pubmed publisher
  9. Streit A, Bernasconi L, Sergeev P, Cruz A, Steinmann Zwicky M. mgm 1, the earliest sex-specific germline marker in Drosophila, reflects expression of the gene esg in male stem cells. Int J Dev Biol. 2002;46:159-66 pubmed
    ..However, somatic esg expression is required for the maintenance of male germline stem cells. ..

More Information


  1. Ryder E, Blows F, Ashburner M, Bautista Llacer R, Coulson D, Drummond J, et al. The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. Genetics. 2004;167:797-813 pubmed
    ..In addition, a further 37,000 deletions, selectable by molecular screening, may be generated. We are now using the collection to generate a second-generation deficiency kit that is precisely mapped to the genome sequence. ..
  2. Chen X, Lu C, Morillo Prado J, Eun S, Fuller M. Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. Development. 2011;138:2441-50 pubmed publisher
    ..Together, the action of the tMAC and tTAF cell type-specific chromatin and transcription machinery leads to loss of Polycomb and release of stalled Pol II from the terminal differentiation gene promoters, allowing robust transcription. ..
  3. O Keefe D, Thomas S, Bolin K, Griggs E, Edgar B, Buttitta L. Combinatorial control of temporal gene expression in the Drosophila wing by enhancers and core promoters. BMC Genomics. 2012;13:498 pubmed publisher
  4. Caporilli S, Yu Y, Jiang J, White Cooper H. The RNA export factor, Nxt1, is required for tissue specific transcriptional regulation. PLoS Genet. 2013;9:e1003526 pubmed publisher
  5. Ryder E, Ashburner M, Bautista Llacer R, Drummond J, Webster J, Johnson G, et al. The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. Genetics. 2007;177:615-29 pubmed
    ..Finally, we provide a computational resource that facilitates selection of other mapped FRT-bearing elements that, when combined with the DrosDel collection, can theoretically generate over half a million precisely mapped deletions. ..
  6. Di Cara F, Cavaliere D, Galliero V, Polito L, Digilio F. Expressional and functional analysis of the male-specific cluster mst36F during Drosophila spermatogenesis. Insect Mol Biol. 2010;19:807-13 pubmed publisher
    ..We obtained a reduction of fertility in the transgenic adult males compared to the wild type. These data suggest that the Mst36Fa and Mst36Fb proteins may have an important role in the production of functional sperm. ..