Nhe2

Summary

Gene Symbol: Nhe2
Description: Na[+]/H[+] hydrogen exchanger 2
Alias: CG9255, CG9256, DmNHE2, Dmel\CG9256, Dnhe2, NHE2, nhe2, Na[+]/H[+] hydrogen exchanger 2, CG9256-PA, CG9256-PB, CG9256-PC, CG9256-PD, CG9256-PE, CG9256-PF, CG9256-PG, CG9256-PH, CG9256-PI, CG9256-PJ, CG9256-PK, CG9256-PL, Nhe2-PA, Nhe2-PB, Nhe2-PC, Nhe2-PD, Nhe2-PE, Nhe2-PF, Nhe2-PG, Nhe2-PH, Nhe2-PI, Nhe2-PJ, Nhe2-PK, Nhe2-PL
Species: fruit fly

Top Publications

  1. Simons M, Gault W, Gotthardt D, Rohatgi R, Klein T, Shao Y, et al. Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat Cell Biol. 2009;11:286-94 pubmed publisher
    ..that Dsh membrane localization is dependent on the Na(+)/H(+) exchange activity of the plasma membrane exchanger Nhe2. Manipulating Nhe2 expression levels in the eye causes PCP defects, and Nhe2 interacts genetically with Fz...
  2. Day J, Wan S, Allan A, Kean L, Davies S, Gray J, et al. Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. J Cell Sci. 2008;121:2612-9 pubmed publisher
    ..Thus, both CG10806 and CG31052 are functionally members of the CPA2 gene family, colocalise to the same apical membrane as the plasma membrane V-ATPase and show distinct ion specificities, as expected for the Wieczorek exchanger. ..
  3. Petzoldt A, Gleixner E, Fumagalli A, Vaccari T, Simons M. Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium. Dis Model Mech. 2013;6:689-700 pubmed publisher
    ..In summary, our in vivo-findings demonstrate that increased levels of V-ATPase C subunit induce a Eiger/JNK-dependent cell transformation within an epithelial organ that recapitulates early carcinoma stages. ..
  4. Koh T, Verstreken P, Bellen H. Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Neuron. 2004;43:193-205 pubmed
    ..Our data suggest that Dap160, like dynamin, is involved in synaptic vesicle retrieval at active and periactive zones. ..
  5. Marie B, Sweeney S, Poskanzer K, Roos J, Kelly R, Davis G. Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth. Neuron. 2004;43:207-19 pubmed
    ..We present a model in which Dap160 scaffolds both endocytic machinery and essential synaptic signaling systems to the periactive zone to coordinately control structural and functional synapse development. ..
  6. Grillo Hill B, Choi C, Jimenez Vidal M, Barber D. Increased H⁺ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. elife. 2015;4: pubmed publisher
    ..Synthetic lethality with reduced H(+) efflux and activated oncogene expression could be exploited therapeutically to restrain cancer progression while limiting off-target effects. ..