Gene Symbol: Nep3
Description: Neprilysin 3
Alias: CEC, CG9565, DmeNEP3, Dmel\CG9565, NEP3, dNEP3, nep3, neprilysin 3, CG9565-PA, CG9565-PB, CG9565-PC, Nep3-PA, Nep3-PB, Nep3-PC
Species: fruit fly
Turner A, Isaac R, Coates D. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function. Bioessays. 2001;23:261-9 pubmed
..These model organisms also provide convenient systems for examining cell-specific expression, developmental and functional roles of this peptidase family, and reveal the power of functional genomics. ..
Meyer H, Panz M, Albrecht S, Drechsler M, Wang S, Hüsken M, et al
. Drosophila metalloproteases in development and differentiation: the role of ADAM proteins and their relatives. Eur J Cell Biol. 2011;90:770-8 pubmed publisher
..Herein we summarize our results with a particular focus on metalloproteases with known or potential roles in tissue differentiation. ..
Turrel O, Lampin Saint Amaux A, Preat T, Goguel V. Drosophila Neprilysins Are Involved in Middle-Term and Long-Term Memory. J Neurosci. 2016;36:9535-46 pubmed publisher
..The data show that these two neurons play a critical role in targeting neuropeptides essential for MTM and LTM. ..
Bland N, Pinney J, Thomas J, Turner A, Isaac R. Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships. BMC Evol Biol. 2008;8:16 pubmed publisher
..reconstructed only one relationship between chordate and invertebrate clusters, that of the ECE sub-group and the DmeNEP3 related genes...
Lang M, Fan Q, Wang L, Zheng Y, Xiao G, Wang X, et al
. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates A?42-induced Alzheimer's disease-like symptoms. Neurobiol Aging. 2013;34:2604-12 pubmed publisher
..Early manipulation of brain copper uptake can have a great effect on A? pathology. ..
Coates D, Siviter R, Isaac R. Exploring the Caenorhabditis elegans and Drosophila melanogaster genomes to understand neuropeptide and peptidase function. Biochem Soc Trans. 2000;28:464-9 pubmed
Iijima Ando K, Hearn S, Granger L, Shenton C, Gatt A, Chiang H, et al
. Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and. J Biol Chem. 2008;283:19066-76 pubmed publisher
..Down-regulation of NEP activity in aging brains may be an evolutionarily conserved phenomenon, which could predispose humans to developing late-onset AD. ..
Sitnik J, Francis C, Hens K, Huybrechts R, Wolfner M, Callaerts P. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Genetics. 2014;196:781-97 pubmed publisher