Gene Symbol: NEP
Description: Neprilysin 1
Alias: CG5894, CG5905, CG5914, DmeNEP1, Dmel\CG5905, NEP, NEP1, dNEP1, nep1, neprilysin 1, CG5905-PA, CG5905-PB, CG5905-PC, CG5905-PD, Nep1-PA, Nep1-PB, Nep1-PC, Nep1-PD
Species: fruit fly

Top Publications

  1. Turner A, Isaac R, Coates D. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function. Bioessays. 2001;23:261-9 pubmed
    Neprilysin (NEP), a thermolysin-like zinc metalloendopeptidase, plays an important role in turning off peptide signalling events at the cell surface...
  2. Bland N, Pinney J, Thomas J, Turner A, Isaac R. Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships. BMC Evol Biol. 2008;8:16 pubmed publisher
    ..primarily resolved into groups containing no other taxa, bar the two nematode genes associated with Drosophila DmeNEP1 and DmeNEP4...
  3. Rebeiz M, Jikomes N, Kassner V, Carroll S. Evolutionary origin of a novel gene expression pattern through co-option of the latent activities of existing regulatory sequences. Proc Natl Acad Sci U S A. 2011;108:10036-43 pubmed publisher
    ..However, gains of novel expression patterns were much less frequent. One gain was observed for the Neprilysin-1 (Nep1) gene, which has evolved a unique expression pattern in optic lobe neuroblasts of Drosophila santomea...
  4. Lang M, Fan Q, Wang L, Zheng Y, Xiao G, Wang X, et al. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates A?42-induced Alzheimer's disease-like symptoms. Neurobiol Aging. 2013;34:2604-12 pubmed publisher
    ..whereas it was accompanied by a trend of decreased expression of amyloid-? degradation proteases (including NEP1-3 and IDE) with age and reduced Cu-A? interaction-induced oxidative stress in Ctr1C RNAi flies...
  5. Coates D, Siviter R, Isaac R. Exploring the Caenorhabditis elegans and Drosophila melanogaster genomes to understand neuropeptide and peptidase function. Biochem Soc Trans. 2000;28:464-9 pubmed
  6. Iijima Ando K, Hearn S, Granger L, Shenton C, Gatt A, Chiang H, et al. Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and. J Biol Chem. 2008;283:19066-76 pubmed publisher
    ..Neprilysin (NEP) is one of the rate-limiting Abeta-degrading enzymes, and its enhancement ameliorates extracellular amyloid ..
  7. Meyer H, Panz M, Albrecht S, Drechsler M, Wang S, Hüsken M, et al. Drosophila metalloproteases in development and differentiation: the role of ADAM proteins and their relatives. Eur J Cell Biol. 2011;90:770-8 pubmed publisher
    ..Herein we summarize our results with a particular focus on metalloproteases with known or potential roles in tissue differentiation. ..
  8. McNeil C, Bain C, Macdonald S. Multiple Quantitative Trait Loci Influence the Shape of a Male-Specific Genital Structure in Drosophila melanogaster. G3 (Bethesda). 2011;1:343-51 pubmed publisher
    ..These genes are good candidates to harbor naturally segregating polymorphisms contributing to posterior lobe shape. ..
  9. Panz M, Vitos Faleato J, Jendretzki A, Heinisch J, Paululat A, Meyer H. A novel role for the non-catalytic intracellular domain of Neprilysins in muscle physiology. Biol Cell. 2012;104:553-68 pubmed publisher
    ..On the basis of their involvement in essential physiological processes, proteins of the Nep family constitute putative therapeutic agents as well as targets in different diseases, including Alzheimer's ..

More Information


  1. Ivanov D, Escott Price V, Ziehm M, Magwire M, Mackay T, Partridge L, et al. Longevity GWAS Using the Drosophila Genetic Reference Panel. J Gerontol A Biol Sci Med Sci. 2015;70:1470-8 pubmed publisher
    ..This analysis suggests that our understanding of the genetic basis of natural variation in lifespan from induced mutations is incomplete. ..
  2. Jacobsen T, Cain D, Paul L, Justiniano S, Alli A, Mullins J, et al. Functional analysis of genes differentially expressed in the Drosophila wing disc: role of transcripts enriched in the wing region. Genetics. 2006;174:1973-82 pubmed
    ..However, there are both technical and biological limitations to this approach, including the efficacy of RNAi and the role that gene redundancy may play in masking phenotypes. ..
  3. Sitnik J, Francis C, Hens K, Huybrechts R, Wolfner M, Callaerts P. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Genetics. 2014;196:781-97 pubmed publisher
    ..Using RNAi we individually targeted the five Nep genes most closely related to vertebrate neprilysin, Nep1-5, to investigate their roles in reproduction...
  4. Turrel O, Lampin Saint Amaux A, Preat T, Goguel V. Drosophila Neprilysins Are Involved in Middle-Term and Long-Term Memory. J Neurosci. 2016;36:9535-46 pubmed publisher
    ..The data show that these two neurons play a critical role in targeting neuropeptides essential for MTM and LTM. ..