Gene Symbol: nej
Description: nejire
Alias: CBP, CBP/p300, CBP_, CG15319, CG15321, Cbp, Crbp, Dmel\CG15319, Dmel_CG15321, Nej, Nejire, anon-WO0147981.11, anon-WO03040301.89, cbp, dCBP, dKAT3, dmCBP, l(1)G0112, l(1)G0350, l(1)G0470, nej CBP, p300, p300/CBP, nejire, CBP/Nejire, CG15319-PB, CG15319-PC, CG15319-PD, CG15319-PE, CREB binding protein, CREB-binding protein, cyclic AMP response element binding protein, drosophila CREB-binding, drosophila CREB-binding protein, lethal (1) G0112, lethal (1) G0350, lethal (1) G0470, nej-PB, nej-PC, nej-PD, nej-PE, protein
Species: fruit fly

Top Publications

  1. Murone M, Rosenthal A, de Sauvage F. Hedgehog signal transduction: from flies to vertebrates. Exp Cell Res. 1999;253:25-33 pubmed
    ..In the following review, we will not discuss in detail the role of Hh as a morphogen, but rather focus on its signal transduction pathway and its role in various human disorders. ..
  2. Lilja T, Qi D, Stabell M, Mannervik M. The CBP coactivator functions both upstream and downstream of Dpp/Screw signaling in the early Drosophila embryo. Dev Biol. 2003;262:294-302 pubmed
    ..In this situation, dCBP acts downstream of Smad protein phosphorylation, presumably via direct interactions with the Drosophila Smad protein Mad...
  3. Das C, Lucia M, Hansen K, Tyler J. CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature. 2009;459:113-7 pubmed publisher
    ..Here we demonstrate that the histone acetyl transferase CBP (also known as Nejire) in flies and CBP and p300 (Ep300) in humans acetylate H3K56, whereas Drosophila Sir2 and human SIRT1 and SIRT2 ..
  4. Holmqvist P, Mannervik M. Genomic occupancy of the transcriptional co-activators p300 and CBP. Transcription. 2013;4:18-23 pubmed publisher
    The p300 and CBP co-activators are histone acetylases and central regulators of transcription in metazoans. The genomic occupancy of p300/CBP detected by ChIP-seq experiments can be used to identify transcriptional enhancers...
  5. Crump N, Hazzalin C, Bowers E, Alani R, Cole P, Mahadevan L. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A. 2011;108:7814-9 pubmed publisher H3K4me3 is mediated by the same lysine acetyltransferase, p300/cAMP response element binding (CREB)-binding protein (CBP), in both mouse and fly cells...
  6. Kumar J, Jamal T, Doetsch A, Turner F, Duffy J. CREB binding protein functions during successive stages of eye development in Drosophila. Genetics. 2004;168:877-93 pubmed
    ..How this process is managed remains a poorly understood paradigm. Members of the CREB binding protein (CBP)/p300 family have been shown to influence development by (1) acting as bridging molecules between the ..
  7. Fu D, Wen Y, Ma J. The co-activator CREB-binding protein participates in enhancer-dependent activities of bicoid. J Biol Chem. 2004;279:48725-33 pubmed
    ..In this report, we describe experiments to analyze the role of the Drosophila co-activator dCBP in Bcd-mediated activation...
  8. Bodai L, Pallos J, Thompson L, Marsh J. Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease. Neurodegener Dis. 2012;9:104-6 pubmed publisher
    ..genetic interaction tests in Drosophila to determine whether specific acetyltransferases belonging to distinct protein families influence polyglutamine pathology...
  9. Ludlam W, Taylor M, Tanner K, Denu J, Goodman R, Smolik S. The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster. Mol Cell Biol. 2002;22:3832-41 pubmed
    ..We show that the intrinsic AT function of CBP in Drosophila melanogaster (dCBP) is necessary to maintain a dCBP overexpression phenotype in the eye, for the in vivo activation of a specific ..

More Information


  1. Tie F, Banerjee R, Saiakhova A, Howard B, Monteith K, Scacheri P, et al. Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing. Development. 2014;141:1129-39 pubmed publisher
    ..Polycomb silencing is also antagonized by TRX-dependent H3K27 acetylation by CREB-binding protein (CBP). We show that perturbation of Polycomb silencing by TRX overexpression requires CBP...
  2. Akimaru H, Chen Y, Dai P, Hou D, Nonaka M, Smolik S, et al. Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature. 1997;386:735-8 pubmed
    ..Here we show that Drosophila CBP (dCBP) functions as a coactivator of Ci, suggesting that the dCBP-Ci interaction may shed light on the contribution of ..
  3. Ashe H, Mannervik M, Levine M. Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo. Development. 2000;127:3305-12 pubmed
    ..We also present evidence that the activation of Dpp/Scw target genes depends on the Drosophila homolog of the CBP histone acetyltransferase.
  4. Akimaru H, Hou D, Ishii S. Drosophila CBP is required for dorsal-dependent twist gene expression. Nat Genet. 1997;17:211-4 pubmed
    Although CREB-binding protein (CBP) functions as a co-activator of many transcription factors, relatively little is known about the physiological role of CBP...
  5. Kirilly D, Wong J, Lim E, Wang Y, Zhang H, Wang C, et al. Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila. Neuron. 2011;72:86-100 pubmed publisher
    ..factors, from which a Brahma (Brm)-containing chromatin remodeler and a histone acetyltransferase CREB-binding protein (CBP) were identified for their critical roles in initiating dendrite pruning...
  6. Lilja T, Aihara H, Stabell M, Nibu Y, Mannervik M. The acetyltransferase activity of Drosophila CBP is dispensable for regulation of the Dpp pathway in the early embryo. Dev Biol. 2007;305:650-8 pubmed
    The CBP protein is a transcriptional co-activator and histone acetyltransferase. Reduced expression of Drosophila CBP (dCBP) in the early embryo specifically impairs signaling by the TGF-beta molecules Dpp and Screw (Scw)...
  7. Bodai L, Zsindely N, Gáspár R, Kristó I, Komonyi O, Boros I. Ecdysone induced gene expression is associated with acetylation of histone H3 lysine 23 in Drosophila melanogaster. PLoS ONE. 2012;7:e40565 pubmed publisher
    ..We found that dCBP, which is encoded by the nejire gene, acetylates H3 lysine 23 in vivo, and silencing of nejire leads to reduced expression of the Eip74EF and ..
  8. He F, Saunders T, Wen Y, Cheung D, Jiao R, ten Wolde P, et al. Shaping a morphogen gradient for positional precision. Biophys J. 2010;99:697-707 pubmed publisher
    ..Here, we compare the positional precision provided by the Drosophila morphogenetic protein Bicoid (Bcd) in wild-type (wt) embryos with embryos lacking an interacting cofactor...
  9. Fu D, Ma J. Interplay between positive and negative activities that influence the role of Bicoid in transcription. Nucleic Acids Res. 2005;33:3985-93 pubmed
    The Drosophila mophogenetic protein Bicoid (Bcd) can activate transcription in a concentration-dependent manner in embryos. It contains a self-inhibitory domain that can interact with the co-repressor Sin3A...
  10. Goodman R, Smolik S. CBP/p300 in cell growth, transformation, and development. Genes Dev. 2000;14:1553-77 pubmed
  11. Tie F, Banerjee R, Stratton C, Prasad Sinha J, Stepanik V, Zlobin A, et al. CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing. Development. 2009;136:3131-41 pubmed publisher
    ..The Trithorax protein (TRX), which associates with the histone acetyltransferase CBP, is required for maintenance of transcriptionally ..
  12. Waltzer L, Bienz M. A function of CBP as a transcriptional co-activator during Dpp signalling. EMBO J. 1999;18:1630-41 pubmed
    CBP/p300 is a transcriptional co-activator that is recruited to enhancers by various DNA-binding proteins, including proteins whose activity is controlled by extracellular signals...
  13. Holmqvist P, Boija A, Philip P, Crona F, Stenberg P, Mannervik M. Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos. PLoS Genet. 2012;8:e1002769 pubmed publisher
    CBP and the related p300 protein are widely used transcriptional co-activators in metazoans that interact with multiple transcription factors...
  14. Miotto B, Sagnier T, Bérenger H, Bohmann D, Pradel J, Graba Y. Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis. Genes Dev. 2006;20:101-12 pubmed
    ..This study establishes a direct link among JNK signaling, DFos phosphorylation, chromatin modification, and AP-1-dependent transcription and its importance in a developing organism. ..
  15. Tie F, Banerjee R, Conrad P, Scacheri P, Harte P. Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27. Mol Cell Biol. 2012;32:2323-34 pubmed publisher
    ..We previously showed that the Drosophila melanogaster acetyltransferase CREB-binding protein (CBP) acetylates histone H3 lysine 27 (H3K27ac), thereby directly blocking its trimethylation (H3K27me3) by ..
  16. Bantignies F, Goodman R, Smolik S. The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in Drosophila. Proc Natl Acad Sci U S A. 2002;99:2895-900 pubmed
    The development of Drosophila requires the function of the CREB-binding protein, dCBP...
  17. Okada M, Akimaru H, Hou D, Takahashi T, Ishii S. Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc. EMBO J. 2002;21:675-84 pubmed
    ..Mutations of the multiple AACNG sequences in the cyclin B promoter also abolished the promoter activity. These results indicate that dMyb regulates the G(2)/M transition by inducing cyclin B expression via binding to its promoter. ..
  18. Petruk S, Sedkov Y, Riley K, Hodgson J, Schweisguth F, Hirose S, et al. Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference. Cell. 2006;127:1209-21 pubmed
    ..We propose that TAC1 promotes the mosaic pattern of Ubx expression by facilitating transcriptional elongation of bxd ncRNAs, which represses Ubx transcription. ..
  19. Smolik S, Jones K. Drosophila dCBP is involved in establishing the DNA replication checkpoint. Mol Cell Biol. 2007;27:135-46 pubmed
    ..In this report, we show that loss of dCBP in Drosophila cells and eye discs results in a defect in the cell cycle arrest induced by stalled DNA replication...
  20. Mallik M, Lakhotia S. Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models. Genetics. 2010;184:927-45 pubmed publisher
    ..hnRNP) Hrb87F and of the transcriptional regulator, cAMP response element binding (CREB) binding protein (CBP). Levels of CBP RNA and protein were reciprocally affected by hsromega transcript levels in eye disc cells...
  21. Fanti L, Perrini B, Piacentini L, Berloco M, Marchetti E, Palumbo G, et al. The trithorax group and Pc group proteins are differentially involved in heterochromatin formation in Drosophila. Chromosoma. 2008;117:25-39 pubmed
    ..These results strongly suggest that trx-G proteins, along with some Pc-G proteins, play an active role in heterochromatin formation in Drosophila. ..
  22. Attisano L, Wrana J. Smads as transcriptional co-modulators. Curr Opin Cell Biol. 2000;12:235-43 pubmed
    ..Thus, Smads function as transcriptional co-modulators to regulate TGFbeta-dependent gene expression. ..
  23. Ogden S, Ascano M, Stegman M, Robbins D. Regulation of Hedgehog signaling: a complex story. Biochem Pharmacol. 2004;67:805-14 pubmed
    ..The HSC consists of the Kinesin Related Protein, Costal2 (Cos2), the serine-threonine protein kinase. Fused (Fu) and Ci...
  24. Sela N, Kim E, Ast G. The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates. Genome Biol. 2010;11:R59 pubmed publisher
    ..However, no extensive analysis has compared the effects of TEs on the transcriptomes of mammals, non-mammalian vertebrates and invertebrates...
  25. Behrens J. Cross-regulation of the Wnt signalling pathway: a role of MAP kinases. J Cell Sci. 2000;113 ( Pt 6):911-9 pubmed
    ..Since TAK1 is activated by TGF-(beta) and various cytokines, it might provide an entry point for regulation of the Wnt system by other pathways. In addition, alterations in TAK1-NLK might play a role in cancer. ..
  26. Giles R, Peters D, Breuning M. Conjunction dysfunction: CBP/p300 in human disease. Trends Genet. 1998;14:178-83 pubmed
    CBP and its homolog p300 are large nuclear molecules that coordinate a variety of transcriptional pathways with chromatin remodeling...
  27. Takeyama K, Ito S, Sawatsubashi S, Shirode Y, Yamamoto A, Suzuki E, et al. A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor. Biosci Biotechnol Biochem. 2004;68:1209-15 pubmed
    ..Therefore, Drosophila with the hAR AF-1 transgene provides a relevant genetic system in which to uncover novel functions of vertebrate steroid hormone receptors and to screen for novel AF-1 co-regulators. ..
  28. Boulanger M, Miranda T, Clarke S, Di Fruscio M, Suter B, Lasko P, et al. Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4. Biochem J. 2004;379:283-9 pubmed
    The role of arginine methylation in Drosophila melanogaster is unknown. We identified a family of nine PRMTs (protein arginine methyltransferases) by sequence homology with mammalian arginine methyltransferases, which we have named DART1 ..
  29. Doiguchi M, Nakagawa T, Imamura Y, Yoneda M, Higashi M, Kubota K, et al. SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation. Sci Rep. 2016;6:20179 pubmed publisher
    ..This activity was column purified and demonstrated to be composed of the enzymatic activities of CREB-binding protein (CBP) and SMARCAD1, which belongs to the Etl1 subfamily of the Snf2 family of helicase-related proteins...
  30. Taylor J, Taye A, Campbell C, Kazemi Esfarjani P, Fischbeck K, MIN K. Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes Dev. 2003;17:1463-8 pubmed
    Sequestration of the transcriptional coactivator CREB-binding protein (CBP), a histone acetyltransferase, has been implicated in the pathogenesis of polyglutamine expansion neurodegenerative disease...
  31. Wang X, Sterne G, Ye B. Regulatory mechanisms underlying the differential growth of dendrites and axons. Neurosci Bull. 2014;30:557-68 pubmed publisher
    ..The knowledge of these underlying molecular mechanisms not only expands our understanding about how neural circuits are wired, but also provides insights that will aid in the rational design of therapies for neurological diseases. ..
  32. Maves L, Schubiger G. Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenance. Curr Opin Genet Dev. 2003;13:472-9 pubmed
    ..An important future goal is to address how signaling pathways interact with chromatin structure to regulate and maintain the proper expression of selector genes. ..
  33. Steffen P, Ringrose L. What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory. Nat Rev Mol Cell Biol. 2014;15:340-56 pubmed publisher
    ..Several recent studies have advanced our understanding of the molecular mechanisms of this epigenetic memory during DNA replication and mitosis. ..
  34. Stofanko M, Kwon S, Badenhorst P. Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity. PLoS ONE. 2010;5:e14051 pubmed publisher
    ..Taken together, our data suggest that lamellocytes arise from plasmatocytes and that plasmatocytes may be inherently plastic, possessing the ability to differentiate further into lamellocytes upon appropriate challenge. ..
  35. Hung H, Maurer C, Kay S, Weber F. Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP. J Biol Chem. 2007;282:31349-57 pubmed
    ..Here we show that the Drosophila ortholog of the CBP/p300 family of transcription co-activators, nejire (nej), is an intrinsic component of the circadian clock that performs regulatory functions for circadian ..
  36. Tie F, Banerjee R, Fu C, Stratton C, Fang M, Harte P. Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain. Proc Natl Acad Sci U S A. 2016;113:E744-53 pubmed publisher
    ..Here, we identify a novel activity of PC: inhibition of the histone acetylation activity of CREB-binding protein (CBP)...
  37. Luo L, Siah C, Cai Y. Engrailed acts with Nejire to control decapentaplegic expression in the Drosophila ovarian stem cell niche. Development. 2017;144:3224-3231 pubmed publisher
    ..Further data suggest that En forms a complex with Nejire (Nej), the Drosophila ortholog of histone acetyltransferase CBP/p300, and directs Nej to this cis-..
  38. Schmidt I, Franzdóttir S, Edenfeld G, Rodrigues F, Zierau A, Klämbt C. Transcriptional regulation of peripheral glial cell differentiation in the embryonic nervous system of Drosophila. Glia. 2011;59:1264-72 pubmed publisher
    ..To uncover additional regulators, we have conducted a genetic screen and report the identification of two additional transcriptional regulators involved in the control of peripheral glial migration: nejire and tango.
  39. Nusse R. WNT targets. Repression and activation. Trends Genet. 1999;15:1-3 pubmed
    ..Recent work sheds light on how this switch between repression and activation is regulated. ..
  40. Tögel M, Meyer H, Lehmacher C, Heinisch J, Pass G, Paululat A. The bHLH transcription factor hand is required for proper wing heart formation in Drosophila. Dev Biol. 2013;381:446-59 pubmed publisher
    ..At the protein level, ?-Spectrin and Dystroglycan are misdistributed suggesting a defect in the costameric network...
  41. Cavarec L, Kamphausen T, Dubourg B, Callebaut I, Lemeunier F, Metivier D, et al. Identification and characterization of Moca-cyp. A Drosophila melanogaster nuclear cyclophilin. J Biol Chem. 2002;277:41171-82 pubmed
    ..The 120-kDa nuclear Moca-cyp protein belongs to a subfamily of large cyclophilins sharing structural and enzymatic features: their highly conserved N-..
  42. Grieder N, Charlafti I, Kloter U, Jackle H, Schäfer U, Gehring W. Misexpression screen in Drosophila melanogaster aiming to reveal novel factors involved in formation of body parts. Genetics. 2007;175:1707-18 pubmed
    ..In the other line, the arista is transformed into a tubular structure, resembling an abnormal leg. We found that ectopic expression of abrupt was responsible for this potential transformation of the arista. ..
  43. Boija A, Mahat D, Zare A, Holmqvist P, Philip P, Meyers D, et al. CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Mol Cell. 2017;68:491-503.e5 pubmed publisher
    ..Here, we identify a novel activity of the histone acetyltransferase p300/CREB-binding protein (CBP) in regulating promoter-proximal paused Pol II...
  44. Hou D, Akimaru H, Ishii S. Trans-activation by the Drosophila myb gene product requires a Drosophila homologue of CBP. FEBS Lett. 1997;413:60-4 pubmed
    ..of Schneider cells with a plasmid expressing the Drosophila homologue of transcriptional co-activator CBP (dCBP) results in transactivation by D-Myb. Using this assay system, the functional domains of D-Myb were analyzed...
  45. Yin V, Thummel C, Bashirullah A. Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. J Cell Biol. 2007;178:85-92 pubmed
    ..We identify the CREB binding protein (CBP) transcriptional cofactor as essential for salivary gland cell death...
  46. Waltzer L, Vandel L, Bienz M. Teashirt is required for transcriptional repression mediated by high Wingless levels. EMBO J. 2001;20:137-45 pubmed
    ..Finally, we demonstrate that the zinc finger protein Teashirt behaves as a transcriptional repressor in transfected mammalian cells...
  47. Boija A, Mannervik M. Initiation of diverse epigenetic states during nuclear programming of the Drosophila body plan. Proc Natl Acad Sci U S A. 2016;113:8735-40 pubmed publisher
    ..At the onset of cell specification, Dorsal recruits the CBP/p300 coactivator to the regulatory regions of defined target genes in the presumptive neuroectoderm, resulting in their ..
  48. Lee Y, Stallcup M. Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription. Nucleic Acids Res. 2006;34:5052-9 pubmed
    ..We previously demonstrated that a developmentally essential protein, Flightless-I (Fli-I), serves as a coactivator for nuclear receptor-mediated transcription...
  49. Gisselbrecht S, Barrera L, Porsch M, Aboukhalil A, Estep P, Vedenko A, et al. Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos. Nat Methods. 2013;10:774-80 pubmed publisher
    ..Application of eFS to other cell types and organisms should accelerate the cataloging of enhancers and understanding how transcriptional regulation is encoded in them. ..
  50. Tabin C, McMahon A. Recent advances in hedgehog signalling. Trends Cell Biol. 1997;7:442-6 pubmed
    ..This review discusses these new findings and their implications for HH signalling. ..
  51. Aza Blanc P, Kornberg T. Ci: a complex transducer of the hedgehog signal. Trends Genet. 1999;15:458-62 pubmed
    ..Here, we highlight recent advances in the Ci story, and discuss remaining questions whose resolution promise to help explain how morphogens like Hh signal their distant targets. ..
  52. Philip P, Boija A, Vaid R, Churcher A, Meyers D, Cole P, et al. CBP binding outside of promoters and enhancers in Drosophila melanogaster. Epigenetics Chromatin. 2015;8:48 pubmed publisher
    CREB-binding protein (CBP, also known as nejire) is a transcriptional co-activator that is conserved in metazoans...
  53. Kwon E, Hayashi Y, Otsuki K, Hirose F, Nishida Y, Yoo M, et al. Armadillo/Pangolin regulates PCNA and DREF promoter activities. Biochim Biophys Acta. 2004;1679:256-62 pubmed
    ..From the published reports of an inhibitory role, we expected that Drosophila CREB-binding protein (dCBP) would interfere with activation. However, effects were only observed with the DREF but not the PCNA gene...
  54. Fry C, Peterson C. Chromatin remodeling enzymes: who's on first?. Curr Biol. 2001;11:R185-97 pubmed
    ..Here we review recent developments concerning the role of chromatin remodeling enzymes in gene regulation, and propose several models to explain how different chromatin remodeling activities can be functionally coupled. ..
  55. Ingham P. Transducing Hedgehog: the story so far. EMBO J. 1998;17:3505-11 pubmed
    ..Elucidating the mechanisms by which Hedgehog signals are transduced will thus have widespread implications for our understanding of both normal development and disease. ..
  56. Goodrich L, Scott M. Hedgehog and patched in neural development and disease. Neuron. 1998;21:1243-57 pubmed
  57. Cutler T, Sarkar A, Moran M, Steffensmeier A, Puli O, Mancini G, et al. Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer's Disease. PLoS ONE. 2015;10:e0137691 pubmed publisher
    ..We identified a histone acetylase, CREB Binding Protein (CBP), as a genetic modifier of Aβ42 mediated neurodegeneration...
  58. Novak A, Dedhar S. Signaling through beta-catenin and Lef/Tcf. Cell Mol Life Sci. 1999;56:523-37 pubmed
    ..polyposis coli and axin/conductin causes beta-catenin to interact with the beta-transducin repeat-containing protein which results in its ubiquitination and degradation...
  59. Newfeld S, Takaesu N. An analysis using the hobo genetic system reveals that combinatorial signaling by the Dpp and Wg pathways regulates dpp expression in leading edge cells of the dorsal ectoderm in Drosophila melanogaster. Genetics. 2002;161:685-92 pubmed
    ..that combinatorial signaling by the Wingless (Wg) pathway, the Dpp pathway, and the transcriptional coactivator Nejire (CBP/p300) regulates dpp(F11) expression in these cells...
  60. Jia S, Flores Saaib R, Courey A. The Dorsal Rel homology domain plays an active role in transcriptional regulation. Mol Cell Biol. 2002;22:5089-99 pubmed
    ..The two classes appear to define distinct protein interaction surfaces on opposite faces of the RHD...
  61. Ito S, Fujiyama Nakamura S, Kimura S, Lim J, Kamoshida Y, Shiozaki Sato Y, et al. Epigenetic silencing of core histone genes by HERS in Drosophila. Mol Cell. 2012;45:494-504 pubmed publisher
    ..HERS protein is phosphorylated by a cyclin-dependent kinase (Cdk) at the end of S-phase...
  62. Lim C, Lee J, Choi C, Kim J, Doh E, Choe J. Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster. Mol Cell Biol. 2007;27:4876-90 pubmed
    ..Here, using transgenic fly models, we show that CREB-binding protein (CBP) participates in the transcriptional regulation of the Drosophila CLOCK/CYCLE (dCLK/CYC) heterodimer...
  63. Reddy B, Bajpe P, Bassett A, Moshkin Y, Kozhevnikova E, Bezstarosti K, et al. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol Cell Biol. 2010;30:5234-44 pubmed publisher
    ..addition, we identified the fly homolog of human Deleted in oral cancer 1 (DOC1), also known as CDK2-associated protein 1 (CDK2AP1), as a bona fide NuRD subunit...
  64. Flici H, Cattenoz P, Komonyi O, Laneve P, Erkosar B, Karatas O, et al. Interlocked loops trigger lineage specification and stable fates in the Drosophila nervous system. Nat Commun. 2014;5:4484 pubmed publisher
    ..In sum, we identify an efficient strategy triggering cell identity, a process altered in pathological conditions such as cancer. ..
  65. Smolik S. Heterochromatin-mediated gene silencing is not affected by Drosophila CBP activity. J Hered. 2009;100:465-72 pubmed publisher
    b>Cyclic AMP Response Element Binding protein (CREB)-binding protein (CBP) is an acetyltransferase important for modifying histones and chromatin-associated proteins and thus affecting transcription and other DNA metabolic processes...
  66. Parker D, Ni Y, Chang J, Li J, Cadigan K. Wingless signaling induces widespread chromatin remodeling of target loci. Mol Cell Biol. 2008;28:1815-28 pubmed
    ..becomes stabilized and translocates to the nucleus, where it binds to the sequence-specific DNA binding protein TCF to activate transcription of target genes...
  67. Chen Y, Goodman R, Smolik S. Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo. Mol Cell Biol. 2000;20:1616-25 pubmed
    CREB-binding protein (CBP) serves as a transcriptional coactivator in multiple signal transduction pathways...
  68. Mizzen C, Allis C. Transcription. New insights into an old modification. Science. 2000;289:2290-1 pubmed
  69. van Eyk C, O Keefe L, Lawlor K, Samaraweera S, McLeod C, Price G, et al. Perturbation of the Akt/Gsk3-? signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. Hum Mol Genet. 2011;20:2783-94 pubmed publisher
  70. Petruk S, Sedkov Y, Smith S, Krajewski W, Nakamura T, Canaani E, et al. Purification and biochemical properties of the Drosophila TAC1 complex. Methods Enzymol. 2004;377:255-66 pubmed
  71. Jung J, Bonini N. CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease. Science. 2007;315:1857-9 pubmed
    ..excision repair and a regulator of DNA repair adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB)-binding protein-a histone acetyltransferase (HAT) whose decreased activity contributes to polyQ disease...
  72. Singh M, Raj K, Sarkar S. Drosophila Myc, a novel modifier suppresses the poly(Q) toxicity by modulating the level of CREB binding protein and histone acetylation. Neurobiol Dis. 2014;63:48-61 pubmed publisher
    ..Overexpression of human form of mutant SCA3 protein with 78 poly(Q) repeats leads to the formation of inclusion bodies and increases the cellular toxicity in ..
  73. Hueston C, Olsen D, Li Q, Okuwa S, Peng B, Wu J, et al. Chromatin Modulatory Proteins and Olfactory Receptor Signaling in the Refinement and Maintenance of Fruitless Expression in Olfactory Receptor Neurons. PLoS Biol. 2016;14:e1002443 pubmed publisher
    ..This regulation requires the chromatin modulatory protein Alhambra (Alh)...
  74. Smith S, Petruk S, Sedkov Y, Cho E, Tillib S, Canaani E, et al. Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex. Nat Cell Biol. 2004;6:162-7 pubmed
    ..HMTase) activity and histone acetyltransferase activity through Trithorax (Trx) and CREB-binding protein (CBP), respectively...
  75. Johnson R, Scott M. New players and puzzles in the Hedgehog signaling pathway. Curr Opin Genet Dev. 1998;8:450-6 pubmed
    ..The role of Hh in carcinogenesis is underscored by the identification of mutations in several pathway components in skin and brain tumors. ..
  76. Hilgers V, Lemke S, Levine M. ELAV mediates 3' UTR extension in the Drosophila nervous system. Genes Dev. 2012;26:2259-64 pubmed publisher
    ..We propose that this mechanism for coordinating 3' UTR extension may be generally used in a variety of cellular processes. ..
  77. Lee H, Kahn T, Simcox A, Schwartz Y, Pirrotta V. Genome-wide activities of Polycomb complexes control pervasive transcription. Genome Res. 2015;25:1170-81 pubmed publisher
    ..We show, however, that H2AK118ub does not mediate the global PRC2 activity or the global repression and is predominantly produced by a new complex involving L(3)73Ah, a homolog of mammalian PCGF3. ..
  78. Latouche M, Lasbleiz C, Martin E, Monnier V, Debeir T, Mouatt Prigent A, et al. A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes. J Neurosci. 2007;27:2483-92 pubmed
    ..7 (SCA7) is a neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the ataxin 7 (ATXN7) protein, a member of a multiprotein complex involved in histone acetylation...