Gene Symbol: ND1
Description: NADH dehydrogenase subunit 1
Alias: NADH dehydrogenase subunit 1
Species: fruit fly

Top Publications

  1. Lewis D, Farr C, Kaguni L. Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons. Insect Mol Biol. 1995;4:263-78 pubmed
    ..yakuba mtDNA. All genes encoded in the mtDNA of both species are in identical locations and orientations. Nucleotide substitution analysis reveals that tRNA and rRNA genes evolve at less than half the rate of protein coding genes. ..
  2. Roberti M, Polosa P, Bruni F, Musicco C, Gadaleta M, Cantatore P. DmTTF, a novel mitochondrial transcription termination factor that recognises two sequences of Drosophila melanogaster mitochondrial DNA. Nucleic Acids Res. 2003;31:1597-604 pubmed
    ..The existence of two DmTTF binding sites might serve not only to stop transcription but also to control the overlapping of a large number of transcripts generated by the peculiar transcription mechanism operating in this organism. ..
  3. Roberti M, Bruni F, Loguercio Polosa P, Manzari C, Gadaleta M, Cantatore P. MTERF3, the most conserved member of the mTERF-family, is a modular factor involved in mitochondrial protein synthesis. Biochim Biophys Acta. 2006;1757:1199-206 pubmed
    ..it decreased to a variable extent the rate of labelling of about half of the mitochondrial polypeptides, with ND1 being the most affected by D-MTERF3 depletion...
  4. Stewart J, Beckenbach A. Characterization of mature mitochondrial transcripts in Drosophila, and the implications for the tRNA punctuation model in arthropods. Gene. 2009;445:49-57 pubmed publisher
    ..Where multiple tRNA genes are present, as between nad3 and nad5, they are removed sequentially in a 3' to 5' direction. ..
  5. Guitart T, Picchioni D, Piñeyro D, Ribas De Pouplana L. Human mitochondrial disease-like symptoms caused by a reduced tRNA aminoacylation activity in flies. Nucleic Acids Res. 2013;41:6595-608 pubmed publisher
    ..In conclusion, the fly model generated in this work reproduces typical characteristics of pathologies caused by mutations in the mitochondrial aminoacylation system, and can be useful to assess therapeutic approaches. ..
  6. Kashikawa M, Amikura R, Nakamura A, Kobayashi S. Mitochondrial small ribosomal RNA is present on polar granules in early cleavage embryos of Drosophila melanogaster. Dev Growth Differ. 1999;41:495-502 pubmed
    ..Taken together, it is speculated that mtsrRNA and mtlrRNA are part of the translation machinery localized to polar granules, which is essential for pole cell formation. ..
  7. Bruni F, Manzari C, Filice M, Loguercio Polosa P, Colella M, Carmone C, et al. D-MTERF5 is a novel factor modulating transcription in Drosophila mitochondria. Mitochondrion. 2012;12:492-9 pubmed publisher
    ..Co-regulation by DREF (DNA Replication-related Element binding Factor) of D-MTERF5 and DmTTF implies that expression of the two factors needs to be co-ordinated to ensure fine modulation of Drosophila mitochondrial transcription. ..
  8. Soldath P, Wegener M, Sander B, Rosenberg T, Duno M, Wibrand F, et al. Leber hereditary optic neuropathy due to a new ND1 mutation. Ophthalmic Genet. 2017;38:480-485 pubmed publisher
    ..3,395A>G mutation in the ND1 gene...
  9. Tsai H, Lin R, Hsieh T. Drosophila mitochondrial topoisomerase III alpha affects the aging process via maintenance of mitochondrial function and genome integrity. J Biomed Sci. 2016;23:38 pubmed publisher
    ..The results reported here demonstrate that mitochondrial Top3? ablation results in mitochondrial genome instability and its dysfunction, thereby accelerating the aging process. ..

More Information


  1. Cooper B, Burrus C, Ji C, Hahn M, Montooth K. Similar Efficacies of Selection Shape Mitochondrial and Nuclear Genes in Both Drosophila melanogaster and Homo sapiens. G3 (Bethesda). 2015;5:2165-76 pubmed publisher
    ..Thus, despite a smaller Ne, mitochondrial loci of both flies and humans appear to experience similar efficacies of purifying selection as do loci in the recombining nuclear genome. ..
  2. Scialò F, Sriram A, Naudí A, Ayala V, Jové M, Pamplona R, et al. Target of rapamycin activation predicts lifespan in fruit flies. Cell Cycle. 2015;14:2949-58 pubmed publisher
    ..Our results, dissociate metabolic rate and lifespan in wild type flies and instead link nutrient sensing signaling with longevity as predicted by the hyperfunction theory. ..
  3. Lim D, Lee L, Oh C, Kim N, Hwang S, Han S, et al. Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs. J Cell Biochem. 2013;114:418-27 pubmed publisher
    ..Our data support a potential role for the endo-siRNA pathway in energy homeostasis through regulation of mitochondrial metabolism. ..
  4. Bratic A, Wredenberg A, Gronke S, Stewart J, Mourier A, Ruzzenente B, et al. The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster. PLoS Genet. 2011;7:e1002324 pubmed publisher
    ..We thus report a novel function of BSF in flies and demonstrate that it has an important intra-mitochondrial role, which is essential for maintaining mtDNA gene expression and oxidative phosphorylation. ..
  5. Garesse R. Drosophila melanogaster mitochondrial DNA: gene organization and evolutionary considerations. Genetics. 1988;118:649-63 pubmed
    ..The analysis of nucleotide changes reveals a similar frequency for transitions and transversions, and reflects a strong bias against G + C on both strands. The predominant type of transition is strand specific. ..
  6. Ding D, Whittaker K, Lipshitz H. Mitochondrially encoded 16S large ribosomal RNA is concentrated in the posterior polar plasm of early Drosophila embryos but is not required for pole cell formation. Dev Biol. 1994;163:503-15 pubmed
    ..In contrast, NADH dehydrogenase subunit 1 RNA, which is transcribed from the same strand of the mitochondrial genome just downstream of the 12S ..
  7. Barrio E, Latorre A, Moya A. Phylogeny of the Drosophila obscura species group deduced from mitochondrial DNA sequences. J Mol Evol. 1994;39:478-88 pubmed
    ..e., affinis and pseudoobscura), whereas the obscura subgroup remains heterogeneous assemblage that could be reasonably subdivided into at least two complexes (i.e., subobscura and obscura). ..
  8. Kobayashi S, Amikura R, Okada M. Presence of mitochondrial large ribosomal RNA outside mitochondria in germ plasm of Drosophila melanogaster. Science. 1993;260:1521-4 pubmed
    ..This suggests that a product from the mitochondrial genome, along with nuclear products, participates in a key event in embryonic development: determination of the germ line. ..
  9. Seligmann H. An overlapping genetic code for frameshifted overlapping genes in Drosophila mitochondria: antisense antitermination tRNAs UAR insert serine. J Theor Biol. 2012;298:51-76 pubmed publisher
    ..Parallel genetic systems coded by an additional mitochondrial genetic code in Drosophila confirm similar phenomena in primate mitochondria. ..
  10. Xie X, Dubrovsky E. Knockout of Drosophila RNase ZL impairs mitochondrial transcript processing, respiration and cell cycle progression. Nucleic Acids Res. 2015;43:10364-75 pubmed publisher
    ..This study implicates Drosophila RNase Z(L) in a novel retrograde signaling pathway initiated by the damage in mitochondria and manifested in a cell cycle delay before the mitotic entry. ..
  11. Griciuc A, Roux M, Merl J, Giangrande A, Hauck S, Aron L, et al. Proteomic survey reveals altered energetic patterns and metabolic failure prior to retinal degeneration. J Neurosci. 2014;34:2797-812 pubmed publisher
    ..Our study offers a glimpse into the intricate higher order interactions that underlie PN dysfunction and provides a useful resource for identifying other molecular networks that mediate Rho toxicity in PNs. ..
  12. Calleja M, Pena P, Ugalde C, Ferreiro C, Marco R, Garesse R. Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced. J Biol Chem. 1993;268:18891-7 pubmed
    ..The decline in the levels of beta H(+)-ATPase transcript, nuclear-encoded, suggests that not only the mitochondrial machinery, but also the nuclear one involved in mitochondrial biogenesis, is affected during aging. ..
  13. Nunes M, Dolezal M, Schlotterer C. Extensive paternal mtDNA leakage in natural populations of Drosophila melanogaster. Mol Ecol. 2013;22:2106-17 pubmed publisher
    ..Our results indicate that evolutionary studies using mtDNA as a marker might be biased by paternal leakage in this species. ..
  14. Matsuda T, Kanki T, Tanimura T, Kang D, Matsuura E. Effects of overexpression of mitochondrial transcription factor A on lifespan and oxidative stress response in Drosophila melanogaster. Biochem Biophys Res Commun. 2013;430:717-21 pubmed publisher
  15. Durando C, Baker R, Etges W, Heed W, Wasserman M, DeSalle R. Phylogenetic analysis of the repleta species group of the genus Drosophila using multiple sources of characters. Mol Phylogenet Evol. 2000;16:296-307 pubmed publisher
    ..for fragments of four genes-16S ribosomal DNA (16S), cytochrome oxidase II (COII), and nitrogen dehydrogenase 1 (ND1) of the mitochondrial genome and a region of the hunchback (hb) nuclear gene...
  16. Fearnley I, Walker J. Conservation of sequences of subunits of mitochondrial complex I and their relationships with other proteins. Biochim Biophys Acta. 1992;1140:105-34 pubmed
  17. Montagna M, Sassera D, Griggio F, Epis S, Bandi C, Gissi C. Tick-box for 3'-end formation of mitochondrial transcripts in Ixodida, basal chelicerates and Drosophila. PLoS ONE. 2012;7:e47538 pubmed publisher
    ..4 kb translocated region, the other end of which exhibits the nad1 Tick-Box--hinting that this motif could have been involved in metastriate gene order rearrangements...
  18. Ballard J, Youngson N. Review: can diet influence the selective advantage of mitochondrial DNA haplotypes?. Biosci Rep. 2015;35: pubmed publisher
  19. Barry W, Thummel C. The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults. elife. 2016;5: pubmed publisher
    ..These findings establish an animal model for MODY1 and define a developmental reprogramming of metabolism to support the energetic needs of the mature animal. ..
  20. Clancy D. Variation in mitochondrial genotype has substantial lifespan effects which may be modulated by nuclear background. Aging Cell. 2008;7:795-804 pubmed publisher
    ..The limited mtDNA variation in D. melanogaster makes it an ideal organism for biochemical studies to link genotype and aging phenotype. ..
  21. de Paula W, Agip A, Missirlis F, Ashworth R, Vizcay Barrena G, Lucas C, et al. Female and male gamete mitochondria are distinct and complementary in transcription, structure, and genome function. Genome Biol Evol. 2013;5:1969-77 pubmed publisher
    ..Suppressed mitochondrial metabolism in the female germ line may therefore constitute a mechanism for increasing the fidelity of mitochondrial DNA inheritance. ..
  22. Camus M, Clancy D, Dowling D. Mitochondria, maternal inheritance, and male aging. Curr Biol. 2012;22:1717-21 pubmed publisher