ND-PDSW

Summary

Gene Symbol: ND-PDSW
Description: NADH dehydrogenase (ubiquinone) PDSW subunit
Alias: BcDNA:RE65754, CG8844, Dmel\CG8844, NIDM, PDSW, Pdsw, anon-EST:Posey91, l(2)k10101, pdsw, NADH dehydrogenase (ubiquinone) PDSW subunit, CG8844-PDSW-PA, CG8844-PDSW-PB, NADH ubiquinone oxidoreductase PDSW, NADH-ubiquinone oxidoreductase PDSW subunit, NADH:ubiquinone oxidoreductase PDSW subunit, ND-PDSW-PA, ND-PDSW-PB, pdsw
Species: fruit fly

Top Publications

  1. Ohsawa S, Sato Y, Enomoto M, Nakamura M, Betsumiya A, Igaki T. Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Nature. 2012;490:547-51 pubmed publisher
    ..Our findings provide a mechanistic basis for interclonal tumour progression driven by mitochondrial dysfunction and oncogenic Ras...
  2. Nakamura M, Ohsawa S, Igaki T. Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila. Nat Commun. 2014;5:5264 pubmed publisher
    ..Our data suggest that mitochondrial defects promote Ras-induced cellular senescence and thereby contribute to tumour progression through SASP. ..
  3. Mandal S, Guptan P, Owusu Ansah E, Banerjee U. Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev Cell. 2005;9:843-54 pubmed
    ..We demonstrate that in multiple tissues the mitochondrion has a direct and specific role in enforcing a G1-S cell cycle checkpoint during periods of energy deprivation. ..
  4. Liao T, Call G, Guptan P, Cespedes A, Marshall J, Yackle K, et al. An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Genetics. 2006;174:525-33 pubmed
    ..We have molecularly characterized six complementation groups and, surprisingly, each encodes a mitochondrial protein. Therefore, we believe our screen to be an efficient method for identifying genes with mitochondrial function. ..
  5. Owusu Ansah E, Yavari A, Mandal S, Banerjee U. Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint. Nat Genet. 2008;40:356-61 pubmed publisher
    ..Thus, our results indicate that the mitochondrion can use AMP and ROS at sublethal concentrations as independent signaling molecules to modulate cell cycle progression. ..