Gene Symbol: ND-ACP
Description: NADH dehydrogenase (ubiquinone) acyl carrier protein
Alias: ACPM, CG9160, Dmel\CG9160, MTACP1A, MTACP1B, ND-AcC, l(3)1303, l(3)j4A6, mtACP, mtACP1, mtACP1A, mtACP1B, mtacp1, NADH dehydrogenase (ubiquinone) acyl carrier protein, CG9160-PA, CG9160-PB, CG9160-PC, NADH ubiquinone oxidoreductase ACP, NADH ubiquinone oxidoreductase acyl carrier protein, NADH-ubiquinone oxidoreductase acyl carrier protein, NADH-ubiquinone oxidoreductase acyl-carrier subunit, NADH:ubiquinone oxidoreductase acyl carrier, ND-ACP-PA, ND-ACP-PB, ND-ACP-PC, acyl carrier protein, mitochondrial acyl carrier protein, mitochondrial acyl carrier protein 1, mitochondrial acyl carrier protein of electron transport complex I
Species: fruit fly

Top Publications

  1. Raker V, Mironov A, Gelfand M, Pervouchine D. Modulation of alternative splicing by long-range RNA structures in Drosophila. Nucleic Acids Res. 2009;37:4533-44 pubmed publisher
    ..Thus, base-pairing interactions within introns, even those occurring over long distances, are more frequent modulators of alternative splicing than is currently assumed. ..
  2. Ragone G, Caizzi R, Moschetti R, Barsanti P, De Pinto V, Caggese C. The Drosophila melanogaster gene for the NADH:ubiquinone oxidoreductase acyl carrier protein: developmental expression analysis and evidence for alternatively spliced forms. Mol Gen Genet. 1999;261:690-7 pubmed
    We have isolated the Drosophila melanogaster gene encoding the mitochondrial acyl carrier protein (mtACP), a subunit of NADH:ubiquinone oxidoreductase involved in de novo fatty acid synthesis in the mitochondrion...
  3. Wei H, Shu H, Price J. Functional genomic analysis of the 61D-61F region of the third chromosome of Drosophila melanogaster. Genome. 2003;46:1049-58 pubmed
    ..AC005847). Six essential complementation groups were assigned to specific genes, including genes encoding a porphobilinogen deaminase and a Sac1-like protein. ..
  4. Tiefenböck S, Baltzer C, Egli N, Frei C. The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. EMBO J. 2010;29:171-83 pubmed publisher
    ..Taken together, our data place Spargel at a nodal point for the integration of mitochondrial activity to tissue and organismal metabolism and growth. ..
  5. Kanda H, Igaki T, Okano H, Miura M. Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death. Proc Natl Acad Sci U S A. 2011;108:18977-82 pubmed publisher
    ..This result suggests a link between sensitivity to cell death and metabolic activity in cancer. ..
  6. Banerjee K, Ayyub C, Sengupta S, Kolthur Seetharam U. dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies. Aging (Albany NY). 2012;4:206-23 pubmed
    ..In conclusion, these findings highlight the central role that fatbody dSir2 plays in linking metabolism to organismal physiology and its importance for survival...
  7. Golovnin A, Kostyuchenko M, Georgiev P, Melnikova L. Mod(mdg4)-58.8, isoform of mod(mdg4) loci, directly interacts with MTACP1A and MTACP1B proteins of Drosophila melanogaster. Dokl Biochem Biophys. 2016;466:5-8 pubmed publisher
    ..8 protein (isoform P), a product of mod(mdg4) locus, directly interacts with mtACP1A and mtACP1B proteins...
  8. Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, et al. Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database. Mol Gen Genet. 1999;261:64-70 pubmed
    ..Our experimental strategy represents an efficient approach to the identification and interspecies comparison of genes encoding products targeted to the mitochondrion. ..
  9. Xu Y, Malhotra A, Ren M, Schlame M. The enzymatic function of tafazzin. J Biol Chem. 2006;281:39217-24 pubmed
    ..The data show that Drosophila tafazzin is a CoA-independent, acyl-specific phospholipid transacylase with substrate preference for cardiolipin and phosphatidylcholine. ..

More Information


  1. Hegan P, Mermall V, Tilney L, Mooseker M. Roles for Drosophila melanogaster myosin IB in maintenance of enterocyte brush-border structure and resistance to the bacterial pathogen Pseudomonas entomophila. Mol Biol Cell. 2007;18:4625-36 pubmed
    ..These results indicate that Myo1B may play a role in the local midgut response pathway of the Imd innate immune response to Gram-negative bacterial infection. ..