Gene Symbol: ND-75
Description: NADH dehydrogenase (ubiquinone) 75 kDa subunit
Alias: CG2286, Dmel\CG2286, ND75, NDUFS1, NUAM, NADH dehydrogenase (ubiquinone) 75 kDa subunit, CG2286-PA, CG2286-PB, FBpp0071128, NADH ubiquinone oxidoreductase 75 kDa, NADH-ubiquinone oxidoreductase 75 kDa subunit, NADH:ubiquinone oxidoreductase 75 kDa subunit, NADH:ubiquinone reductase 75 kDa subunit, NADH:ubiquinone reductase 75-kD subunit precursor, NADH:ubiquinone reductase 75kD subunit precursor, ND-75-PA, ND-75-PB
Species: fruit fly

Top Publications

  1. Hochmuth C, Biteau B, Bohmann D, Jasper H. Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell. 2011;8:188-99 pubmed publisher
    ..Our findings establish Keap1 and Nrf2 as a critical redox management system that regulates stem cell function in high-turnover tissues. ..
  2. Hur J, Stork D, Walker D. Complex-I-ty in aging. J Bioenerg Biomembr. 2014;46:329-35 pubmed publisher
    ..We suggest that manipulations that increase or decrease complex I activity both converge on improved mitochondrial homeostasis during aging, resulting in prolonged lifespan. ..
  3. Choo A, O Keefe L, Lee C, Gregory S, Shaukat Z, Colella A, et al. Tumor suppressor WWOX moderates the mitochondrial respiratory complex. Genes Chromosomes Cancer. 2015;54:745-61 pubmed publisher
    ..Thus, the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity. ..
  4. Ballard J, Chernoff B, James A. Divergence of mitochondrial dna is not corroborated by nuclear dna, morphology, or behavior in Drosophila simulans. Evolution. 2002;56:527-45 pubmed
    ..We conclude with an iterated appeal to include phylogenetic and statistical tests of neutrality as a supplement to phylogenetic and population genetic analyses when using mtDNA as an evolutionary marker...
  5. Owusu Ansah E, Banerjee U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature. 2009;461:537-41 pubmed publisher
    ..Our results lead to a model that could be extended to reveal a probable signalling role for ROS in the differentiation of CMPs in mammalian haematopoietic development and oxidative stress response. ..
  6. Lim D, Lee L, Oh C, Kim N, Hwang S, Han S, et al. Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs. J Cell Biochem. 2013;114:418-27 pubmed publisher
    ..Our data support a potential role for the endo-siRNA pathway in energy homeostasis through regulation of mitochondrial metabolism. ..
  7. Wu Z, Sawada T, Shiba K, Liu S, Kanao T, Takahashi R, et al. Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance. Genes Dev. 2013;27:157-62 pubmed publisher
    ..Genetically, mTORC2 and Trc act upstream of Parkin. Thus, multiplex kinase signaling is acting between PINK1 and Parkin to regulate MQC, a process highly conserved in mammals. ..
  8. Lee K, Wu Z, Song Y, Mitra S, Feroze A, Cheshier S, et al. Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway. Genes Dev. 2013;27:2642-7 pubmed publisher
    ..Our results emphasize the importance of mitochondria to N and NSC biology, with important implications for diseases associated with aberrant N signaling. ..
  9. Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, et al. Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database. Mol Gen Genet. 1999;261:64-70 pubmed
    ..Our experimental strategy represents an efficient approach to the identification and interspecies comparison of genes encoding products targeted to the mitochondrion. ..

More Information


  1. Guitart T, Picchioni D, PiƱeyro D, Ribas De Pouplana L. Human mitochondrial disease-like symptoms caused by a reduced tRNA aminoacylation activity in flies. Nucleic Acids Res. 2013;41:6595-608 pubmed publisher
    ..In conclusion, the fly model generated in this work reproduces typical characteristics of pathologies caused by mutations in the mitochondrial aminoacylation system, and can be useful to assess therapeutic approaches. ..
  2. Hegde V, Vogel R, Feany M. Glia are critical for the neuropathology of complex I deficiency in Drosophila. Hum Mol Genet. 2014;23:4686-92 pubmed publisher
    ..Our results open up an unexpected avenue of research, and could lead to the development of new treatment strategies. ..
  3. Rogers R, Rogina B. Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies. Aging (Albany NY). 2014;6:335-50 pubmed
    ..Our data suggest INDY may be a physiological regulator that modulates intermediary metabolism in response to changes in nutrient availability and organismal needs by modulating dPGC-1. ..
  4. Ma M, Zhao H, Zhao H, Binari R, Perrimon N, Li Z. Wildtype adult stem cells, unlike tumor cells, are resistant to cellular damages in Drosophila. Dev Biol. 2016;411:207-216 pubmed publisher
    ..Together, these data demonstrate that wildtype adult stem cells and tumor cells show dramatic differences in sensitivity to cellular damages, thus providing potential therapeutic implications targeting tumorigenesis. ..