Genomes and Genes
Gene Symbol: ND-75
Description: NADH dehydrogenase (ubiquinone) 75 kDa subunit
Alias: CG2286, Dmel\CG2286, ND75, NDUFS1, NUAM, NADH dehydrogenase (ubiquinone) 75 kDa subunit, CG2286-PA, CG2286-PB, FBpp0071128, NADH ubiquinone oxidoreductase 75 kDa, NADH-ubiquinone oxidoreductase 75 kDa subunit, NADH:ubiquinone oxidoreductase 75 kDa subunit, NADH:ubiquinone reductase 75 kDa subunit, NADH:ubiquinone reductase 75-kD subunit precursor, NADH:ubiquinone reductase 75kD subunit precursor, ND-75-PA, ND-75-PB
Species: fruit fly
- Guitart T, Picchioni D, Piñeyro D, Ribas De Pouplana L. Human mitochondrial disease-like symptoms caused by a reduced tRNA aminoacylation activity in flies. Nucleic Acids Res. 2013;41:6595-608 pubmed publisher..In conclusion, the fly model generated in this work reproduces typical characteristics of pathologies caused by mutations in the mitochondrial aminoacylation system, and can be useful to assess therapeutic approaches. ..
- Hegde V, Vogel R, Feany M. Glia are critical for the neuropathology of complex I deficiency in Drosophila. Hum Mol Genet. 2014;23:4686-92 pubmed publisher..Our results open up an unexpected avenue of research, and could lead to the development of new treatment strategies. ..
- Rogers R, Rogina B. Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies. Aging (Albany NY). 2014;6:335-50 pubmed..Our data suggest INDY may be a physiological regulator that modulates intermediary metabolism in response to changes in nutrient availability and organismal needs by modulating dPGC-1. ..
- Ma M, Zhao H, Zhao H, Binari R, Perrimon N, Li Z. Wildtype adult stem cells, unlike tumor cells, are resistant to cellular damages in Drosophila. Dev Biol. 2016;411:207-216 pubmed publisher..Together, these data demonstrate that wildtype adult stem cells and tumor cells show dramatic differences in sensitivity to cellular damages, thus providing potential therapeutic implications targeting tumorigenesis. ..