ND-42

Summary

Gene Symbol: ND-42
Description: NADH dehydrogenase (ubiquinone) 42 kDa subunit
Alias: A10, CG6343, Dmel\CG6343, ND42, NUDM, NdufA10, NADH dehydrogenase (ubiquinone) 42 kDa subunit, CG6343-PA, CG6343-PB, CG6343-PC, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NADH ubiquinone oxidoreductase 42 kDa, NADH-ubiquinone oxidoreductase 42 kDa subunit, NADH-ubiquinone oxidoreductase subunit, NADH: UBIQUINONE REDUCTASE 42 KD SUBUNIT PRECURSOR, NADH:ubiquinone oxidoreductase 42 kDa subunit, NADH:ubiquinone reductase 42 kD, NADH:ubiquinone reductase 42kD subunit precursor, ND-42-PA, ND-42-PB, ND-42-PC
Species: fruit fly

Top Publications

  1. Hochmuth C, Biteau B, Bohmann D, Jasper H. Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell. 2011;8:188-99 pubmed publisher
    ..Our findings establish Keap1 and Nrf2 as a critical redox management system that regulates stem cell function in high-turnover tissues. ..
  2. Zhang K, Li Z, Jaiswal M, Bayat V, Xiong B, Sandoval H, et al. The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. J Cell Biol. 2013;200:807-20 pubmed publisher
    ..We show that in the cytoplasm, Sicily preprotein interacts with cytosolic Hsp90 to chaperone the CI subunit, ND42, before mitochondrial import...
  3. Morais V, Haddad D, Craessaerts K, De Bock P, Swerts J, Vilain S, et al. PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science. 2014;344:203-7 pubmed publisher
    ..and brain from Pink1(-/-) mice, we found specific loss of phosphorylation of serine-250 in complex I subunit NdufA10. Phosphorylation of serine-250 was needed for ubiquinone reduction by complex I...
  4. Owusu Ansah E, Banerjee U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature. 2009;461:537-41 pubmed publisher
    ..Our results lead to a model that could be extended to reveal a probable signalling role for ROS in the differentiation of CMPs in mammalian haematopoietic development and oxidative stress response. ..
  5. Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, et al. Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database. Mol Gen Genet. 1999;261:64-70 pubmed
    ..Our experimental strategy represents an efficient approach to the identification and interspecies comparison of genes encoding products targeted to the mitochondrion. ..
  6. Pogson J, Ivatt R, Sanchez Martinez A, Tufi R, Wilson E, Mortiboys H, et al. The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. PLoS Genet. 2014;10:e1004815 pubmed publisher
    ..also causes complex I (CI) deficiency, and has recently been suggested to regulate CI through phosphorylation of NDUFA10/ND42 subunit...
  7. Lemos B, Branco A, Hartl D. Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. Proc Natl Acad Sci U S A. 2010;107:15826-31 pubmed publisher
  8. Albrecht S, Barata A, Grosshans J, Teleman A, Dick T. In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis. Cell Metab. 2011;14:819-29 pubmed publisher
    ..Midgut enterocytes are identified as prominent sites of age-dependent cytosolic H(2)O(2) accumulation. A longer life span correlated with increased formation of oxidants in the gut, rather than a decrease. ..
  9. Rogers R, Rogina B. Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies. Aging (Albany NY). 2014;6:335-50 pubmed
    ..Our data suggest INDY may be a physiological regulator that modulates intermediary metabolism in response to changes in nutrient availability and organismal needs by modulating dPGC-1. ..

More Information

Publications13

  1. Liu L, Zhang K, Sandoval H, Yamamoto S, Jaiswal M, Sanz E, et al. Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell. 2015;160:177-90 pubmed publisher
  2. Choo A, O Keefe L, Lee C, Gregory S, Shaukat Z, Colella A, et al. Tumor suppressor WWOX moderates the mitochondrial respiratory complex. Genes Chromosomes Cancer. 2015;54:745-61 pubmed publisher
    ..Thus, the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity. ..
  3. Chen K, Lin G, Haelterman N, Ho T, Li T, Li Z, et al. Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. elife. 2016;5: pubmed publisher
    ..Our results indicate that an iron/sphingolipid/Pdk1/Mef2 pathway may play a role in FRDA. ..
  4. Dragojlovic Munther M, Martinez Agosto J. Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors. Development. 2012;139:3752-63 pubmed