Gene Symbol: ND-39
Description: NADH dehydrogenase (ubiquinone) 39 kDa subunit
Alias: CG6020, Dmel\CG6020, GM13757p, NDUFA9, NUEM, Ndufa9, NADH dehydrogenase (ubiquinone) 39 kDa subunit, CG6020-PA, CG6020-PB, FBpp0077859, NADH dehydrogenase, NADH ubiquinone oxidoreductase 39 kDa, NADH-ubiquinone oxidoreductase 39 kDa subunit, NADH:ubiquinone oxidoreductase 39 kDa subunit, ND-39-PA, ND-39-PB
Species: fruit fly

Top Publications

  1. Sanz A, Soikkeli M, Portero Otin M, Wilson A, Kemppainen E, McIlroy G, et al. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Proc Natl Acad Sci U S A. 2010;107:9105-10 pubmed publisher
    ..In yeast, the single-subunit NADH dehydrogenase Ndi1 serves as a non-proton-translocating alternative enzyme that replaces complex I, bringing about the ..
  2. Hegde V, Vogel R, Feany M. Glia are critical for the neuropathology of complex I deficiency in Drosophila. Hum Mol Genet. 2014;23:4686-92 pubmed publisher
    ..Our results open up an unexpected avenue of research, and could lead to the development of new treatment strategies. ..
  3. Kemppainen K, Rinne J, Sriram A, Lakanmaa M, Zeb A, Tuomela T, et al. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet. 2014;23:2078-93 pubmed publisher
    ..These findings confirm the potential utility of alternative respiratory chain enzymes as tools to combat mitochondrial disease, while indicating important limitations thereof. ..
  4. Gospodaryov D, Lushchak O, Rovenko B, Perkhulyn N, Gerards M, Tuomela T, et al. Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Biochim Biophys Acta. 2014;1837:1861-1869 pubmed publisher
    An assembled cDNA coding for the putative single-subunit NADH dehydrogenase (NDX) of Ciona intestinalis was introduced into Drosophila melanogaster...
  5. Scialò F, Sriram A, Fernández Ayala D, Gubina N, Lõhmus M, Nelson G, et al. Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 2016;23:725-34 pubmed publisher
    ..These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging. ..