ND-19

Summary

Gene Symbol: ND-19
Description: NADH dehydrogenase (ubiquinone) 19 kDa subunit
Alias: CG3683, Dmel\CG3683, NDUFA8, NUPM, Ndufa8, RH23043p, NADH dehydrogenase (ubiquinone) 19 kDa subunit, CG3683-PA, CG3683-PB, CG3683-PC, CG3683-PD, FBpp0072231, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, NADH ubiquinone oxidoreductase 19 kDa, NADH-UBIQUINONE OXIDOREDUCTASE 19 KDA SUBUNIT, NADH:ubiquinone oxidoreductase 19 kDa subunit, ND-19-PA, ND-19-PB, ND-19-PC, ND-19-PD
Species: fruit fly

Top Publications

  1. Sanz A, Soikkeli M, Portero Otin M, Wilson A, Kemppainen E, McIlroy G, et al. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Proc Natl Acad Sci U S A. 2010;107:9105-10 pubmed publisher
    ..Our results support a central role of mitochondrial oxidative phosphorylation complex I in influencing longevity via oxidative stress, independently of pathways connected to nutrition and growth signaling. ..
  2. Esposito G, Vos M, Vilain S, Swerts J, De Sousa Valadas J, Van Meensel S, et al. Aconitase causes iron toxicity in Drosophila pink1 mutants. PLoS Genet. 2013;9:e1003478 pubmed publisher
    ..Thus our data indicate that superoxide-dependent [4Fe-4S] inactivation defines a potential pathogenic cascade that acts independent of mitophagy and links iron toxicity to mitochondrial failure in a PD-relevant model. ..
  3. Kemppainen K, Rinne J, Sriram A, Lakanmaa M, Zeb A, Tuomela T, et al. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet. 2014;23:2078-93 pubmed publisher
    ..These findings confirm the potential utility of alternative respiratory chain enzymes as tools to combat mitochondrial disease, while indicating important limitations thereof. ..
  4. Gospodaryov D, Lushchak O, Rovenko B, Perkhulyn N, Gerards M, Tuomela T, et al. Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Biochim Biophys Acta. 2014;1837:1861-1869 pubmed publisher
    ..However, NDX was able only weakly to complement the phenotypes produced by the knockdown of complex I subunits. ..
  5. Scialò F, Sriram A, Fernández Ayala D, Gubina N, Lõhmus M, Nelson G, et al. Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 2016;23:725-34 pubmed publisher
    ..These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging. ..