Gene Symbol: nAChRbeta2
Description: nicotinic Acetylcholine Receptor beta2
Alias: Acr96Ac, AcrF, CG6798, Dbeta2, Dmel\CG6798, SBD, beta2, beta[[2]], nACR beta 96A, nACRbeta, nAChR, nAChR-beta96A, nAcRbeta, nAcRbeta-96A, nAcRs, nAcr96Ac, sbd, nicotinic acetylcholine receptor beta2, CG6798-PA, CG6798-PB, Dbeta2, SBD, nAChRbeta2-PA, nAChRbeta2-PB, nicotinic acetylcholine receptor beta 96A, second beta-like subunit of drosophila
Species: fruit fly

Top Publications

  1. Perry T, Heckel D, McKenzie J, Batterham P. Mutations in Dalpha1 or Dbeta2 nicotinic acetylcholine receptor subunits can confer resistance to neonicotinoids in Drosophila melanogaster. Insect Biochem Mol Biol. 2008;38:520-8 pubmed publisher
    ..of the mutations found lesions in two nAChR subunit genes, Dalpha1 (encoding an alpha-type subunit) and Dbeta2 (beta-type)...
  2. Dallman J, Allopenna J, Bassett A, Travers A, Mandel G. A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation. J Neurosci. 2004;24:7186-93 pubmed
  3. Rieder L, Savva Y, Reyna M, Chang Y, Dorsky J, Rezaei A, et al. Dynamic response of RNA editing to temperature in Drosophila. BMC Biol. 2015;13:1 pubmed publisher
    ..Environmental cues, in this case temperature, rapidly reprogram the Drosophila transcriptome through RNA editing, presumably resulting in altered proteomic ratios of edited and unedited proteins. ..
  4. Ranz J, Caceres M, Ruiz A. Comparative mapping of cosmids and gene clones from a 1.6 Mb chromosomal region of Drosophila melanogaster in three species of the distantly related subgenus Drosophila. Chromosoma. 1999;108:32-43 pubmed
    ..Finally, our data indicate significant statistical differences in the evolution rate of Muller's element E among lineages, a result that agrees well with the previous cytogenetic data. ..
  5. Caceres M, Ranz J, Barbadilla A, Long M, Ruiz A. Generation of a widespread Drosophila inversion by a transposable element. Science. 1999;285:415-8 pubmed
    ..This is apparently the mechanism by which transposable elements generate natural inversions in Drosophila. ..
  6. Tomizawa M, Zhang N, Durkin K, Olmstead M, Casida J. The neonicotinoid electronegative pharmacophore plays the crucial role in the high affinity and selectivity for the Drosophila nicotinic receptor: an anomaly for the nicotinoid cation--pi interaction model. Biochemistry. 2003;42:7819-27 pubmed
    ..channels, does not apply to the anomalous action of neonicotinoids at the insect nicotinic acetylcholine receptor (nAChR)...
  7. Jepson J, Reenan R. Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem. 2009;284:31391-400 pubmed publisher
  8. Chamaon K, Smalla K, Thomas U, Gundelfinger E. Nicotinic acetylcholine receptors of Drosophila: three subunits encoded by genomically linked genes can co-assemble into the same receptor complex. J Neurochem. 2002;80:149-57 pubmed
    ..Here we have produced specific antibodies against SBD to study, which other nAChR subunits can co-assemble with SBD in receptor complexes of the Drosophila nervous system...
  9. Liu G, Ju X, Cheng J. Selectivity of Imidacloprid for fruit fly versus rat nicotinic acetylcholine receptors by molecular modeling. J Mol Model. 2010;16:993-1002 pubmed publisher
    ..understanding of the mechanisms of selective binding of the representative nicotinic acetylcholine receptor (nAChR) agonist neonicotinoid Imidacloprid (IMI), three-dimensional models of fruit fly alpha 1 beta 2 and rat alpha ..

More Information


  1. Lansdell S, Millar N. The influence of nicotinic receptor subunit composition upon agonist, alpha-bungarotoxin and insecticide (imidacloprid) binding affinity. Neuropharmacology. 2000;39:671-9 pubmed
    ..Imidacloprid bound with very low affinity to the rat alpha4/beta2 nAChR but did so with high affinity to hybrid nAChRs containing Drosophila alpha subunits co-assembled with rat beta2...
  2. Broughton S, Kane N, Arthur B, Yoder M, Greenspan R, Robichon A. Endogenously inhibited protein kinase C in transgenic Drosophila embryonic neuroblasts down regulates the outgrowth of type I and II processes of cultured mature neurons. J Cell Biochem. 1996;60:584-99 pubmed
  3. Denecke S, Nowell C, Fournier Level A, Perry T, Batterham P. The Wiggle Index: An Open Source Bioassay to Assess Sub-Lethal Insecticide Response in Drosophila melanogaster. PLoS ONE. 2015;10:e0145051 pubmed publisher
    ..melanogaster. ..
  4. Schulz R, Sawruk E, M├╝lhardt C, Bertrand S, Baumann A, Phannavong B, et al. D alpha3, a new functional alpha subunit of nicotinic acetylcholine receptors from Drosophila. J Neurochem. 1998;71:853-62 pubmed
    ..Nondesensitizing ACh-evoked inward currents were observed when D alpha3 was coexpressed with the chick beta2 subunit. Half-maximal responses were at approximately 0.15 microM ACh with a Hill coefficient of approximately 1.5...
  5. Lansdell S, Millar N. Dbeta3, an atypical nicotinic acetylcholine receptor subunit from Drosophila : molecular cloning, heterologous expression and coassembly. J Neurochem. 2002;80:1009-18 pubmed
    ..Six nicotinic acetylcholine receptor (nAChR) subunits (four alpha-type and two beta-type) have been cloned previously from the model insect species Drosophila ..
  6. Shinomiya K, Karuppudurai T, Lin T, Lu Z, Lee C, Meinertzhagen I. Candidate neural substrates for off-edge motion detection in Drosophila. Curr Biol. 2014;24:1062-70 pubmed publisher
    ..We hypothesize that T5 computes small-field motion signals by integrating multiple cholinergic Tm inputs using nicotinic and muscarinic cholinoceptors. ..
  7. Sattelle D, Jones A, Sattelle B, Matsuda K, Reenan R, Biggin P. Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster. Bioessays. 2005;27:366-76 pubmed
    ..With the advent of genome sequencing, entire nAChR gene families have now been described for vertebrates and invertebrates...
  8. Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
    ..These results point to a pivotal role for RNA editing in nervous system function. ..
  9. Jepson J, Savva Y, Yokose C, Sugden A, Sahin A, Reenan R. Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem. 2011;286:8325-37 pubmed publisher
    ..Our data demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities. ..
  10. Tomizawa M, Latli B, Casida J. Novel neonicotinoid-agarose affinity column for Drosophila and Musca nicotinic acetylcholine receptors. J Neurochem. 1996;67:1669-76 pubmed
    ..such as the insecticide imidacloprid (IMI) act as agonists at the insect nicotinic acetylcholine receptor (nAChR)...
  11. Gundelfinger E, Hess N. Nicotinic acetylcholine receptors of the central nervous system of Drosophila. Biochim Biophys Acta. 1992;1137:299-308 pubmed
  12. Schafer W. Genetic analysis of nicotinic signaling in worms and flies. J Neurobiol. 2002;53:535-41 pubmed
  13. Lansdell S, Schmitt B, Betz H, Sattelle D, Millar N. Temperature-sensitive expression of Drosophila neuronal nicotinic acetylcholine receptors. J Neurochem. 1997;68:1812-9 pubmed
    Heterologous expression of cloned Drosophila nicotinic acetylcholine receptor (nAChR) subunits indicates that these proteins misfold when expressed in mammalian cell lines at 37 degrees C...
  14. Dupuis J, Louis T, Gauthier M, Raymond V. Insights from honeybee (Apis mellifera) and fly (Drosophila melanogaster) nicotinic acetylcholine receptors: from genes to behavioral functions. Neurosci Biobehav Rev. 2012;36:1553-64 pubmed publisher
    ..The unbalance is striking between the abundant literature on nAChR sensitivity to insecticides and the rarity of information regarding their molecular properties and cognitive ..
  15. Stocker J, Huang H, Wang H, Chang H, Chiu C, Cho C, et al. Reduction of RNA A-to-I editing in Drosophila acclimated to heat shock. Kaohsiung J Med Sci. 2013;29:478-83 pubmed publisher
    ..However, how RNA editing confers heat resistance is more complicated and requires further investigation. ..
  16. Wu M, Robinson J, Joiner W. SLEEPLESS is a bifunctional regulator of excitability and cholinergic synaptic transmission. Curr Biol. 2014;24:621-9 pubmed publisher
    ..Mimicking this antagonism with the nAChR inhibitor mecamylamine or by RNAi knockdown of specific nAChR subunits is sufficient to restore sleep to qvr/sss ..
  17. Baylis H, Sattelle D, Lane N. Genetic analysis of cholinergic nerve terminal function in invertebrates. J Neurocytol. 1996;25:747-62 pubmed
    ..The growing importance of the C. elegans genome as a major research resource is emphasized in this survey. ..
  18. Dent J. Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria. J Mol Evol. 2006;62:523-35 pubmed
    ..well-defined clade of vertebrate cation channel subunits, the alpha 7 nicotinic acetylcholine receptor subunits (nAChR), includes invertebrate orthologues...
  19. Lansdell S, Millar N. Cloning and heterologous expression of Dalpha4, a Drosophila neuronal nicotinic acetylcholine receptor subunit: identification of an alternative exon influencing the efficiency of subunit assembly. Neuropharmacology. 2000;39:2604-14 pubmed
    A neuronal nicotinic acetylcholine receptor (nAChR) subunit, Dalpha4, has been identified and cloned from the fruit fly Drosophila melanogaster, together with several alternatively spliced transcripts...
  20. Ren J, Sun J, Zhang Y, Liu T, Ren Q, Li Y, et al. Down-regulation of Decapping Protein 2 mediates chronic nicotine exposure-induced locomotor hyperactivity in Drosophila. PLoS ONE. 2012;7:e52521 pubmed publisher
    ..Our findings reveal a significant role for the mRNA decapping pathway in developing locomotor hyperactivity in response to chronic nicotine exposure and identify Dcp2 as a potential candidate for future research on nicotine dependence. ..
  21. Takemura S, Karuppudurai T, Ting C, Lu Z, Lee C, Meinertzhagen I. Cholinergic circuits integrate neighboring visual signals in a Drosophila motion detection pathway. Curr Biol. 2011;21:2077-84 pubmed publisher
    ..We propose that Tm2 integrates sign-conserving inputs from neighboring columns to mediate the detection of front-to-back motion generated during forward motion. ..
  22. Sawruk E, Udri C, Betz H, Schmitt B. SBD, a novel structural subunit of the Drosophila nicotinic acetylcholine receptor, shares its genomic localization with two alpha-subunits. FEBS Lett. 1990;273:177-81 pubmed
    ..Here we describe the structure of a cDNA from Drosophila melanogaster which encodes a novel nAChR beta-type subunit (SBD or beta 2)...