Gene Symbol: nAChRbeta1
Description: nicotinic Acetylcholine Receptor beta1
Alias: AChR, AChR64B, ARD, AchR64B, Acr64B, AcrD, Ard, CG11348, CG11348-PA, CG12606, Dbeta1, Dmel\CG11348, ard, beta 64B, nAChR, nAChR-beta64B, nAcR64B, nAcRbeta-64B, nicotinic acetylcholine receptor beta1, AChR protein of drosophila, CG11348-PA, CG11348-PB, nAChRbeta1-PA, nAChRbeta1-PB, nicotinic acetylcholine receptor beta 64B, nicotinic acetylcholine receptorb-64B
Species: fruit fly

Top Publications

  1. Tomizawa M, Latli B, Casida J. Novel neonicotinoid-agarose affinity column for Drosophila and Musca nicotinic acetylcholine receptors. J Neurochem. 1996;67:1669-76 pubmed
    ..such as the insecticide imidacloprid (IMI) act as agonists at the insect nicotinic acetylcholine receptor (nAChR)...
  2. Jepson J, Reenan R. Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem. 2009;284:31391-400 pubmed publisher
  3. Gundelfinger E, Hess N. Nicotinic acetylcholine receptors of the central nervous system of Drosophila. Biochim Biophys Acta. 1992;1137:299-308 pubmed
  4. Lansdell S, Millar N. Cloning and heterologous expression of Dalpha4, a Drosophila neuronal nicotinic acetylcholine receptor subunit: identification of an alternative exon influencing the efficiency of subunit assembly. Neuropharmacology. 2000;39:2604-14 pubmed
    A neuronal nicotinic acetylcholine receptor (nAChR) subunit, Dalpha4, has been identified and cloned from the fruit fly Drosophila melanogaster, together with several alternatively spliced transcripts...
  5. Schloss P, Hermans Borgmeyer I, Betz H, Gundelfinger E. Neuronal acetylcholine receptors in Drosophila: the ARD protein is a component of a high-affinity alpha-bungarotoxin binding complex. EMBO J. 1988;7:2889-94 pubmed
    ..ard gene of Drosophila melanogaster encodes a structural homologue of vertebrate nicotinic acetylcholine receptors (AChR) and is expressed exclusively in nervous tissue...
  6. Shinomiya K, Karuppudurai T, Lin T, Lu Z, Lee C, Meinertzhagen I. Candidate neural substrates for off-edge motion detection in Drosophila. Curr Biol. 2014;24:1062-70 pubmed publisher
    ..We hypothesize that T5 computes small-field motion signals by integrating multiple cholinergic Tm inputs using nicotinic and muscarinic cholinoceptors. ..
  7. Takemura S, Karuppudurai T, Ting C, Lu Z, Lee C, Meinertzhagen I. Cholinergic circuits integrate neighboring visual signals in a Drosophila motion detection pathway. Curr Biol. 2011;21:2077-84 pubmed publisher
    ..We propose that Tm2 integrates sign-conserving inputs from neighboring columns to mediate the detection of front-to-back motion generated during forward motion. ..
  8. Sattelle D, Jones A, Sattelle B, Matsuda K, Reenan R, Biggin P. Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster. Bioessays. 2005;27:366-76 pubmed
    ..With the advent of genome sequencing, entire nAChR gene families have now been described for vertebrates and invertebrates...
  9. Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
    ..These results point to a pivotal role for RNA editing in nervous system function. ..

More Information


  1. Riede I. Proliferative genes induce somatic pairing defects in Drosophila melanogaster and allow replication. Cancer Genet Cytogenet. 1997;97:143-54 pubmed
    ..Thus, mutant proliferative genes induce the S-phase and allow replication of DNA. ..
  2. Ashraf S, McLoon A, Sclarsic S, Kunes S. Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila. Cell. 2006;124:191-205 pubmed
    ..Therefore, we propose that degradative control of the RISC pathway underlies the pattern of synaptic protein synthesis associated with a stable memory. ..
  3. Schulz R, Sawruk E, M├╝lhardt C, Bertrand S, Baumann A, Phannavong B, et al. D alpha3, a new functional alpha subunit of nicotinic acetylcholine receptors from Drosophila. J Neurochem. 1998;71:853-62 pubmed
    ..We have isolated and characterized the gene and the cDNA of a new nAChR subunit from Drosophila...
  4. Bertrand D, Ballivet M, Gomez M, Bertrand S, Phannavong B, Gundelfinger E. Physiological properties of neuronal nicotinic receptors reconstituted from the vertebrate beta 2 subunit and Drosophila alpha subunits. Eur J Neurosci. 1994;6:869-75 pubmed
    Three cDNAs (ALS, D alpha 2 and ARD) isolated from the nervous system of Drosophila and encoding putative nicotinic acetylcholine receptor subunits were expressed in Xenopus oocytes in order to study their functional properties...
  5. Baumann A, Jonas P, Gundelfinger E. Sequence of D alpha 2, a novel alpha-like subunit of Drosophila nicotinic acetylcholine receptors. Nucleic Acids Res. 1990;18:3640 pubmed
  6. Hermans Borgmeyer I, Hoffmeister S, Sawruk E, Betz H, Schmitt B, Gundelfinger E. Neuronal acetylcholine receptors in Drosophila: mature and immature transcripts of the ard gene in the developing central nervous system. Neuron. 1989;2:1147-56 pubmed
    The ARD protein is a Drosophila homolog of vertebrate nicotinic acetylcholine receptor (AChR) polypeptides. Here, an analysis of transcripts of the corresponding ard gene is presented...
  7. Raccuglia D, Mueller U. Temporal integration of cholinergic and GABAergic inputs in isolated insect mushroom body neurons exposes pairing-specific signal processing. J Neurosci. 2014;34:16086-92 pubmed publisher
  8. Lansdell S, Millar N. Dbeta3, an atypical nicotinic acetylcholine receptor subunit from Drosophila : molecular cloning, heterologous expression and coassembly. J Neurochem. 2002;80:1009-18 pubmed
    ..Six nicotinic acetylcholine receptor (nAChR) subunits (four alpha-type and two beta-type) have been cloned previously from the model insect species Drosophila ..
  9. Wadsworth S, Rosenthal L, Kammermeyer K, Potter M, Nelson D. Expression of a Drosophila melanogaster acetylcholine receptor-related gene in the central nervous system. Mol Cell Biol. 1988;8:778-85 pubmed
    ..The Drosophila genomic clone hybridized to salivary gland polytene chromosome 3L within region 64B and was termed AChR64B. A 3-kilobase poly(A)-containing transcript complementary to the AChR64B clone was readily detectable by RNA blot ..
  10. Chamaon K, Schulz R, Smalla K, Seidel B, Gundelfinger E. Neuronal nicotinic acetylcholine receptors of Drosophila melanogaster: the alpha-subunit dalpha3 and the beta-type subunit ARD co-assemble within the same receptor complex. FEBS Lett. 2000;482:189-92 pubmed
    ..Here, we produced Dalpha3-specific antibodies to study which other nAChR subunits can co-assemble with Dalpha3 in receptor complexes of the Drosophila nervous system...
  11. Wu M, Robinson J, Joiner W. SLEEPLESS is a bifunctional regulator of excitability and cholinergic synaptic transmission. Curr Biol. 2014;24:621-9 pubmed publisher
    ..Mimicking this antagonism with the nAChR inhibitor mecamylamine or by RNAi knockdown of specific nAChR subunits is sufficient to restore sleep to qvr/sss ..
  12. Feng G, Deak P, Kasbekar D, Gil D, Hall L. Cytogenetic and molecular localization of tipE: a gene affecting sodium channels in Drosophila melanogaster. Genetics. 1995;139:1679-88 pubmed
    ..Sequencing these transcripts will elucidate the role of the tipE gene product in sodium channel functional regulation. ..
  13. Ren J, Sun J, Zhang Y, Liu T, Ren Q, Li Y, et al. Down-regulation of Decapping Protein 2 mediates chronic nicotine exposure-induced locomotor hyperactivity in Drosophila. PLoS ONE. 2012;7:e52521 pubmed publisher
    ..Our findings reveal a significant role for the mRNA decapping pathway in developing locomotor hyperactivity in response to chronic nicotine exposure and identify Dcp2 as a potential candidate for future research on nicotine dependence. ..
  14. Hermsen B, Stetzer E, Thees R, Heiermann R, Schrattenholz A, Ebbinghaus U, et al. Neuronal nicotinic receptors in the locust Locusta migratoria. Cloning and expression. J Biol Chem. 1998;273:18394-404 pubmed
    We have identified five cDNA clones that encode nicotinic acetylcholine receptor (nAChR) subunits expressed in the nervous system of the locust Locusta migratoria...
  15. Dupuis J, Louis T, Gauthier M, Raymond V. Insights from honeybee (Apis mellifera) and fly (Drosophila melanogaster) nicotinic acetylcholine receptors: from genes to behavioral functions. Neurosci Biobehav Rev. 2012;36:1553-64 pubmed publisher
    ..The unbalance is striking between the abundant literature on nAChR sensitivity to insecticides and the rarity of information regarding their molecular properties and cognitive ..
  16. Jepson J, Savva Y, Yokose C, Sugden A, Sahin A, Reenan R. Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem. 2011;286:8325-37 pubmed publisher
    ..Our data demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities. ..
  17. Schloss P, Betz H, Schroder C, Gundelfinger E. Neuronal nicotinic acetylcholine receptors in Drosophila: antibodies against an alpha-like and a non-alpha-subunit recognize the same high-affinity alpha-bungarotoxin binding complex. J Neurochem. 1991;57:1556-62 pubmed
    ALS and ARD proteins are thought to represent a ligand binding and a structural subunit, respectively, of Drosophila nicotinic acetylcholine receptors (nAChRs)...
  18. Schuster R, Phannavong B, Schroder C, Gundelfinger E. Immunohistochemical localization of a ligand-binding and a structural subunit of nicotinic acetylcholine receptors in the central nervous system of Drosophila melanogaster. J Comp Neurol. 1993;335:149-62 pubmed
    ..antibodies raised against the ligand-binding alpha-like subunit ALS and the putative non-ligand-binding subunit ARD, we find both ALS-like and ARD-like immunoreactivity widely distributed in most neuropiles of the optic lobes, the ..
  19. Hess N, Merz B, Gundelfinger E. Acetylcholine receptors of the Drosophila brain: a 900 bp promoter fragment contains the essential information for specific expression of the ard gene in vivo. FEBS Lett. 1994;346:135-40 pubmed
    The ard gene encodes a beta-subunit of Drosophila nicotinic acetylcholine receptors specifically expressed in a subset of neurons...
  20. Sawruk E, Hermans Borgmeyer I, Betz H, Gundelfinger E. Characterization of an invertebrate nicotinic acetylcholine receptor gene: the ard gene of Drosophila melanogaster. FEBS Lett. 1988;235:40-6 pubmed
    The ard gene encodes a neuronal nicotinic acetylcholine receptor (AChR) protein from Drosophila (ARD protein). Cytogenetically this gene maps at position 64B/C on the left arm of the 3rd chromosome...
  21. Tomizawa M, Zhang N, Durkin K, Olmstead M, Casida J. The neonicotinoid electronegative pharmacophore plays the crucial role in the high affinity and selectivity for the Drosophila nicotinic receptor: an anomaly for the nicotinoid cation--pi interaction model. Biochemistry. 2003;42:7819-27 pubmed
    ..channels, does not apply to the anomalous action of neonicotinoids at the insect nicotinic acetylcholine receptor (nAChR)...
  22. Nair S, Agrawal N, Hasan G. Homeostasis of glutamate neurotransmission is altered in Drosophila Inositol 1,4,5-trisphosphate receptor mutants. Invert Neurosci. 2007;7:137-47 pubmed
  23. Lansdell S, Millar N. The influence of nicotinic receptor subunit composition upon agonist, alpha-bungarotoxin and insecticide (imidacloprid) binding affinity. Neuropharmacology. 2000;39:671-9 pubmed
    ..Imidacloprid bound with very low affinity to the rat alpha4/beta2 nAChR but did so with high affinity to hybrid nAChRs containing Drosophila alpha subunits co-assembled with rat beta2...
  24. Lansdell S, Schmitt B, Betz H, Sattelle D, Millar N. Temperature-sensitive expression of Drosophila neuronal nicotinic acetylcholine receptors. J Neurochem. 1997;68:1812-9 pubmed
    Heterologous expression of cloned Drosophila nicotinic acetylcholine receptor (nAChR) subunits indicates that these proteins misfold when expressed in mammalian cell lines at 37 degrees C...
  25. Baylis H, Sattelle D, Lane N. Genetic analysis of cholinergic nerve terminal function in invertebrates. J Neurocytol. 1996;25:747-62 pubmed
    ..The growing importance of the C. elegans genome as a major research resource is emphasized in this survey. ..
  26. Broughton S, Kane N, Arthur B, Yoder M, Greenspan R, Robichon A. Endogenously inhibited protein kinase C in transgenic Drosophila embryonic neuroblasts down regulates the outgrowth of type I and II processes of cultured mature neurons. J Cell Biochem. 1996;60:584-99 pubmed
  27. Stocker J, Huang H, Wang H, Chang H, Chiu C, Cho C, et al. Reduction of RNA A-to-I editing in Drosophila acclimated to heat shock. Kaohsiung J Med Sci. 2013;29:478-83 pubmed publisher
    ..However, how RNA editing confers heat resistance is more complicated and requires further investigation. ..
  28. Schafer W. Genetic analysis of nicotinic signaling in worms and flies. J Neurobiol. 2002;53:535-41 pubmed