Gene Symbol: nAChRalpha5
Description: nicotinic Acetylcholine Receptor alpha5
Alias: BG:DS05899.4, BG:DS05899.5, CG16878, CG32975, CG4498, CT14633, Dalpha5, Dmel\CG32975, Nic 34E, anon-WO02059370.44, da5, daf, lincRNA.128, lincRNA.S1055, nAChR, nAChRalpha-34E, nAcRalpha-34E, nAcRalpha-34e, nicotinic acetylcholine receptor alpha5, CG32975-PB, CG32975-PD, CG32975-PH, Dalpha5, nAChRalpha5-PB, nAChRalpha5-PD, nAChRalpha5-PH, nicotinic acetylcholine Receptor_34E, nicotinic acetylcholine receptor alpha 34E
Species: fruit fly

Top Publications

  1. Watson G, Chouinard S, Cook K, Geng C, Gifford J, Gustafson G, et al. A spinosyn-sensitive Drosophila melanogaster nicotinic acetylcholine receptor identified through chemically induced target site resistance, resistance gene identification, and heterologous expression. Insect Biochem Mol Biol. 2010;40:376-84 pubmed publisher
    ..laevis oocytes simply by expressing Dalpha6 alone, co-expression of Dalpha6 with an additional nAChR subunit, Dalpha5, and the chaperone protein ric-3 resulted in an acetylcholine- and spinosyn-sensitive receptor with the ..
  2. Sattelle D, Jones A, Sattelle B, Matsuda K, Reenan R, Biggin P. Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster. Bioessays. 2005;27:366-76 pubmed
    ..With the advent of genome sequencing, entire nAChR gene families have now been described for vertebrates and invertebrates...
  3. Grauso M, Reenan R, Culetto E, Sattelle D. Novel putative nicotinic acetylcholine receptor subunit genes, Dalpha5, Dalpha6 and Dalpha7, in Drosophila melanogaster identify a new and highly conserved target of adenosine deaminase acting on RNA-mediated A-to-I pre-mRNA editing. Genetics. 2002;160:1519-33 pubmed
    ..The subunits are designated Dalpha5, Dalpha6, and Dalpha7...
  4. Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
    ..These results point to a pivotal role for RNA editing in nervous system function. ..
  5. Wu P, Ma D, Pierzchala M, Wu J, Yang L, Mai X, et al. The Drosophila acetylcholine receptor subunit D alpha5 is part of an alpha-bungarotoxin binding acetylcholine receptor. J Biol Chem. 2005;280:20987-94 pubmed
    ..A peptide-specific antibody raised against the D alpha5 subunit provides further evidence that this subunit is a component of an alpha-bungarotoxin binding nicotinic acetylcholine receptor from the central nervous system of Drosophila. ..
  6. Takemura S, Karuppudurai T, Ting C, Lu Z, Lee C, Meinertzhagen I. Cholinergic circuits integrate neighboring visual signals in a Drosophila motion detection pathway. Curr Biol. 2011;21:2077-84 pubmed publisher
    ..We propose that Tm2 integrates sign-conserving inputs from neighboring columns to mediate the detection of front-to-back motion generated during forward motion. ..
  7. Barnstedt O, Owald D, Felsenberg J, Brain R, Moszynski J, Talbot C, et al. Memory-Relevant Mushroom Body Output Synapses Are Cholinergic. Neuron. 2016;89:1237-1247 pubmed publisher
    ..Therefore, olfactory memories in Drosophila are likely stored as plasticity of cholinergic synapses. ..
  8. Rieder L, Savva Y, Reyna M, Chang Y, Dorsky J, Rezaei A, et al. Dynamic response of RNA editing to temperature in Drosophila. BMC Biol. 2015;13:1 pubmed publisher
    ..Environmental cues, in this case temperature, rapidly reprogram the Drosophila transcriptome through RNA editing, presumably resulting in altered proteomic ratios of edited and unedited proteins. ..
  9. Raccuglia D, Mueller U. Temporal integration of cholinergic and GABAergic inputs in isolated insect mushroom body neurons exposes pairing-specific signal processing. J Neurosci. 2014;34:16086-92 pubmed publisher

More Information


  1. Jepson J, Savva Y, Yokose C, Sugden A, Sahin A, Reenan R. Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem. 2011;286:8325-37 pubmed publisher
    ..Our data demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities. ..
  2. Jepson J, Reenan R. Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem. 2009;284:31391-400 pubmed publisher
  3. Glazov E, Pheasant M, McGraw E, Bejerano G, Mattick J. Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing. Genome Res. 2005;15:800-8 pubmed
  4. Dupuis J, Louis T, Gauthier M, Raymond V. Insights from honeybee (Apis mellifera) and fly (Drosophila melanogaster) nicotinic acetylcholine receptors: from genes to behavioral functions. Neurosci Biobehav Rev. 2012;36:1553-64 pubmed publisher
    ..The unbalance is striking between the abundant literature on nAChR sensitivity to insecticides and the rarity of information regarding their molecular properties and cognitive ..
  5. Rodriguez J, Menet J, Rosbash M. Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila. Mol Cell. 2012;47:27-37 pubmed publisher
    ..We conclude that ADAR-mediated editing is more widespread than previously indicated and largely occurs cotranscriptionally. ..
  6. Wu M, Robinson J, Joiner W. SLEEPLESS is a bifunctional regulator of excitability and cholinergic synaptic transmission. Curr Biol. 2014;24:621-9 pubmed publisher
    ..Mimicking this antagonism with the nAChR inhibitor mecamylamine or by RNAi knockdown of specific nAChR subunits is sufficient to restore sleep to qvr/sss ..
  7. Agrawal R, Stormo G. Editing efficiency of a Drosophila gene correlates with a distant splice site selection. RNA. 2005;11:563-6 pubmed
    ..In contrast, when editing occurs downstream of alternative splicing, no correlation is seen. These results suggest some models for the coupling of editing and splicing processes. ..
  8. Schafer W. Genetic analysis of nicotinic signaling in worms and flies. J Neurobiol. 2002;53:535-41 pubmed
  9. Keegan L, McGurk L, Palavicini J, Brindle J, Paro S, Li X, et al. Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects. Nucleic Acids Res. 2011;39:7249-62 pubmed publisher
    ..The ADAR1 gene has been lost several times, including during the evolution of insects and crustacea. These data complement our rescue results, supporting the idea that ADAR1 and ADAR2 have evolved highly conserved, distinct functions. ..
  10. Lansdell S, Collins T, Goodchild J, Millar N. The Drosophila nicotinic acetylcholine receptor subunits D?5 and D?7 form functional homomeric and heteromeric ion channels. BMC Neurosci. 2012;13:73 pubmed publisher
    ..Ten nAChR subunits have been identified in the model insect Drosophila melanogaster (D?1-D?7 and D?1-D?3) and a similar ..
  11. Shinomiya K, Karuppudurai T, Lin T, Lu Z, Lee C, Meinertzhagen I. Candidate neural substrates for off-edge motion detection in Drosophila. Curr Biol. 2014;24:1062-70 pubmed publisher
    ..We hypothesize that T5 computes small-field motion signals by integrating multiple cholinergic Tm inputs using nicotinic and muscarinic cholinoceptors. ..
  12. Nakayama M, Matsushita F, Hama C. The matrix protein Hikaru genki localizes to cholinergic synaptic clefts and regulates postsynaptic organization in the Drosophila brain. J Neurosci. 2014;34:13872-7 pubmed publisher
    ..These results indicate that Hig is a specific component of the synaptic cleft matrix of cholinergic synapses and regulates their postsynaptic organization in the CNS. ..
  13. Tomizawa M, Zhang N, Durkin K, Olmstead M, Casida J. The neonicotinoid electronegative pharmacophore plays the crucial role in the high affinity and selectivity for the Drosophila nicotinic receptor: an anomaly for the nicotinoid cation--pi interaction model. Biochemistry. 2003;42:7819-27 pubmed
    ..channels, does not apply to the anomalous action of neonicotinoids at the insect nicotinic acetylcholine receptor (nAChR)...
  14. Perry T, Somers J, Yang Y, Batterham P. Expression of insect α6-like nicotinic acetylcholine receptors in Drosophila melanogaster highlights a high level of conservation of the receptor:spinosyn interaction. Insect Biochem Mol Biol. 2015;64:106-15 pubmed publisher
    ..In the absence of a robust heterologous expression system, this study presents an in vivo model that will be useful in analysing many other aspects of these receptors and their biology. ..
  15. Nakayama M, Suzuki E, Tsunoda S, Hama C. The Matrix Proteins Hasp and Hig Exhibit Segregated Distribution within Synaptic Clefts and Play Distinct Roles in Synaptogenesis. J Neurosci. 2016;36:590-606 pubmed publisher
    ..Furthermore, Hasp regulates levels of DLG and the nAChR subunits Dα6 and Dα7 at postsynaptic terminals...