Gene Symbol: Nab2
Description: Nuclear polyadenosine RNA-binding 2
Alias: BEST:GH27517, BcDNA:LD27873, CG5720, Dmel\CG5720, DnAB2, RE28534, anon-EST:Liang-1.43, clone 1.43, dNab2, nuclear polyadenosine RNA-binding 2, CG5720-PA, Nab2-PA, nuclear polyadenylated RNA-binding 2
Species: fruit fly
Kelly S, Bienkowski R, Banerjee A, Melicharek D, Brewer Z, Marenda D, et al
. The Drosophila ortholog of the Zc3h14 RNA binding protein acts within neurons to pattern axon projection in the developing brain. Dev Neurobiol. 2016;76:93-106 pubmed publisher
The dNab2 polyadenosine RNA binding protein is the D. melanogaster ortholog of the vertebrate ZC3H14 protein, which is lost in a form of inherited intellectual disability (ID). Human ZC3H14 can rescue D...
Pak C, Garshasbi M, Kahrizi K, Gross C, Apponi L, Noto J, et al
. Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. Proc Natl Acad Sci U S A. 2011;108:12390-5 pubmed publisher
..A Drosophila melanogaster model of this disease created by mutation of the gene encoding the ZC3H14 ortholog dNab2, which also binds polyadenosine RNA, reveals that dNab2 is essential for development and required in neurons for ..
Kelly S, Pak C, Garshasbi M, Kuss A, Corbett A, MOBERG K. New kid on the ID block: neural functions of the Nab2/ZC3H14 class of Cys?His tandem zinc-finger polyadenosine RNA binding proteins. RNA Biol. 2012;9:555-62 pubmed publisher
..highlight key questions raised by our study of ZC3H14 and its ortholog in the fruit fly Drosophila melanogaster, dNab2, and comment on future approaches that could provide insights into the cellular and molecular roles of this class ..
Kelly S, Leung S, Pak C, Banerjee A, Moberg K, Corbett A. A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length. RNA. 2014;20:681-8 pubmed publisher
..Saccharomyces cerevisiae, where the protein is termed Nab2, and Drosophila, where the protein has been designated dNab2, little is known about the function of mammalian ZC3H14...
BIENKOWSKI R, Banerjee A, Rounds J, Rha J, Omotade O, Gross C, et al
. The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons. Cell Rep. 2017;20:1372-1384 pubmed publisher
The Drosophila dNab2 protein is an ortholog of human ZC3H14, a poly(A) RNA binding protein required for intellectual function. dNab2 supports memory and axon projection, but its molecular role in neurons is undefined...