Gene Symbol: Naa60
Description: N(alpha)-acetyltransferase 60
Alias: CG18177, DmAAF50213, Dmel\CG18177, Hat4, NAA60, NatF, dNAA60, dNaa60, dNatF, N(alpha)-acetyltransferase 60, CG18177-PA, CG18177-PB, CG18177-PC, Naa60-PA, Naa60-PB, Naa60-PC
Species: fruit fly
Polevoda B, Sherman F. N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. J Mol Biol. 2003;325:595-622 pubmed
..Overall patterns of N-terminal acetylated proteins and the orthologous genes possibly encoding NATs suggest that yeast and higher eukaryotes have the same systems for N-terminal acetylation. ..
Yang X, Yu W, Shi L, Sun L, Liang J, Yi X, et al
. HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Mol Cell. 2011;44:39-50 pubmed publisher
..Here, we report on a member of the GCN5-related N-acetyltransferase superfamily and another B-type HAT, HAT4. Interestingly, HAT4 is localized in the Golgi apparatus and displays a substrate preference for lysine residues of ..
Buff H, Smith A, Korey C. Genetic modifiers of Drosophila palmitoyl-protein thioesterase 1-induced degeneration. Genetics. 2007;176:209-20 pubmed
..A greater understanding of Ppt1 function in these cellular processes will provide valuable insight into the molecular etiology of the neuronal dysfunction underlying the disease. ..
Feller C, FornÃ© I, Imhof A, Becker P. Global and specific responses of the histone acetylome to systematic perturbation. Mol Cell. 2015;57:559-71 pubmed publisher
..Conceivably, the acetylation level is adjusted to maintain the global charge neutralization of chromatin and the stability of nuclei. ..
Silva R, Martinho R. Developmental roles of protein N-terminal acetylation. Proteomics. 2015;15:2402-9 pubmed publisher
..Moreover, we will also propose the existence of tissue and developmental-specific mechanisms that differentially regulate N-Ac. ..
Lin C, Mount S, Jarmołowski A, Makałowski W. Evolutionary dynamics of U12-type spliceosomal introns. BMC Evol Biol. 2010;10:47 pubmed publisher
..Loss of U12 introns or the genes containing them is more common than conversion to the U2-type. The degeneracy of U12-type terminal dinucleotides among natural U12-type introns is higher than previously thought. ..
Van Damme P, Hole K, Pimenta Marques A, Helsens K, Vandekerckhove J, Martinho R, et al
. NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. PLoS Genet. 2011;7:e1002169 pubmed publisher
..NatF's cellular impact was demonstrated in Drosophila cells where NAA60 knockdown induced chromosomal segregation defects...
Praveen K, Wen Y, Matera A. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep. 2012;1:624-31 pubmed publisher
..These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects. ..