Naa60

Summary

Gene Symbol: Naa60
Description: N(alpha)-acetyltransferase 60
Alias: CG18177, DmAAF50213, Dmel\CG18177, Hat4, NAA60, NatF, dNAA60, dNaa60, dNatF, N(alpha)-acetyltransferase 60, CG18177-PA, CG18177-PB, CG18177-PC, Naa60-PA, Naa60-PB, Naa60-PC
Species: fruit fly

Top Publications

  1. Polevoda B, Sherman F. N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. J Mol Biol. 2003;325:595-622 pubmed
    ..Overall patterns of N-terminal acetylated proteins and the orthologous genes possibly encoding NATs suggest that yeast and higher eukaryotes have the same systems for N-terminal acetylation. ..
  2. Yang X, Yu W, Shi L, Sun L, Liang J, Yi X, et al. HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Mol Cell. 2011;44:39-50 pubmed publisher
    ..Here, we report on a member of the GCN5-related N-acetyltransferase superfamily and another B-type HAT, HAT4. Interestingly, HAT4 is localized in the Golgi apparatus and displays a substrate preference for lysine residues of ..
  3. Buff H, Smith A, Korey C. Genetic modifiers of Drosophila palmitoyl-protein thioesterase 1-induced degeneration. Genetics. 2007;176:209-20 pubmed
    ..A greater understanding of Ppt1 function in these cellular processes will provide valuable insight into the molecular etiology of the neuronal dysfunction underlying the disease. ..
  4. Feller C, Forné I, Imhof A, Becker P. Global and specific responses of the histone acetylome to systematic perturbation. Mol Cell. 2015;57:559-71 pubmed publisher
    ..Conceivably, the acetylation level is adjusted to maintain the global charge neutralization of chromatin and the stability of nuclei. ..
  5. Silva R, Martinho R. Developmental roles of protein N-terminal acetylation. Proteomics. 2015;15:2402-9 pubmed publisher
    ..Moreover, we will also propose the existence of tissue and developmental-specific mechanisms that differentially regulate N-Ac. ..
  6. Lin C, Mount S, Jarmołowski A, Makałowski W. Evolutionary dynamics of U12-type spliceosomal introns. BMC Evol Biol. 2010;10:47 pubmed publisher
    ..Loss of U12 introns or the genes containing them is more common than conversion to the U2-type. The degeneracy of U12-type terminal dinucleotides among natural U12-type introns is higher than previously thought. ..
  7. Van Damme P, Hole K, Pimenta Marques A, Helsens K, Vandekerckhove J, Martinho R, et al. NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. PLoS Genet. 2011;7:e1002169 pubmed publisher
    ..NatF's cellular impact was demonstrated in Drosophila cells where NAA60 knockdown induced chromosomal segregation defects...
  8. Praveen K, Wen Y, Matera A. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep. 2012;1:624-31 pubmed publisher
    ..These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects. ..