N

Summary

Gene Symbol: N
Description: Notch
Alias: 16-178, 16-55, CG3936, CT13012, Chp, Dmel\CG3936, EG:140G11.1, EG:163A10.2, NECD, NICD, RICN, anon-EST:Liang-1.12, clone 1.12, dNotch, l(1)3Cb, l(1)Ax, n[fah], notch, shd, spl, swb, notch, CG3936-PA, CG3936-PB, N-PA, N-PB, NICD, abruptex, chopped, confluens, dNotch, facet, notchoid, split, strawberry
Species: fruit fly
Products:     N

Top Publications

  1. Schneider M, Troost T, Grawe F, Martinez Arias A, Klein T. Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome. J Cell Sci. 2013;126:645-56 pubmed publisher
    The tumour suppressor Lethal (2) giant discs (Lgd) is a regulator of endosomal trafficking of the Notch signalling receptor as well as other transmembrane proteins in Drosophila...
  2. Ni J, Zhou R, Czech B, Liu L, Holderbaum L, Yang Zhou D, et al. A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods. 2011;8:405-7 pubmed publisher
    ..We show that shRNAs, modeled on an endogenous microRNA, are extremely effective at silencing gene expression during oogenesis. We also describe our progress toward building a genome-wide shRNA resource. ..
  3. Yousefian J, Troost T, Grawe F, Sasamura T, FORTINI M, Klein T. Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila. J Cell Sci. 2013;126:1583-94 pubmed publisher
    ..The enlarged endosomes contain Notch and other trans-membrane proteins as cargo...
  4. Nagaraj R, Banerjee U. Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway. EMBO J. 2009;28:337-46 pubmed publisher
    Spatial and temporal control of Notch and Wingless (Wg) pathways during development is regulated at multiple levels. Here, we present an analysis of Phyllopod as a coordinated regulator of these two critical signal transduction pathways...
  5. Truman J, Moats W, Altman J, Marin E, Williams D. Role of Notch signaling in establishing the hemilineages of secondary neurons in Drosophila melanogaster. Development. 2010;137:53-61 pubmed publisher
    ..Using both loss-of-function and gain-of-function approaches, we examined the role of Notch signaling in establishing neuronal fates within all of the thoracic secondary lineages...
  6. Lubensky D, Pennington M, Shraiman B, Baker N. A dynamical model of ommatidial crystal formation. Proc Natl Acad Sci U S A. 2011;108:11145-50 pubmed publisher
    ..We observed these stripes experimentally after manipulation of the Notch and scabrous genes...
  7. Hsu H, Drummond Barbosa D. Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands. Dev Biol. 2011;350:290-300 pubmed publisher
    ..Insulin-like peptides are required for maintenance of cap cells (a major component of the niche) via modulation of Notch signaling, and they also control attachment of GSCs to cap cells and E-cadherin levels at the cap cell-GSC ..
  8. Lin G, Xu N, Xi R. Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells. J Mol Cell Biol. 2010;2:37-49 pubmed publisher
    ..Together with the functional analysis with Notch (N), we suggest two separate roles of JAK/STAT signaling in Drosophila ISC lineages: it functions upstream of N, ..
  9. Li X, Erclik T, Bertet C, Chen Z, Voutev R, Venkatesh S, et al. Temporal patterning of Drosophila medulla neuroblasts controls neural fates. Nature. 2013;498:456-62 pubmed publisher
    ..We provide evidence that this temporal sequence in neuroblasts, together with Notch-dependent binary fate choice, controls the diversification of the neuronal progeny...
  10. Soler C, Taylor M. The Him gene inhibits the development of Drosophila flight muscles during metamorphosis. Mech Dev. 2009;126:595-603 pubmed publisher
    ..They are formed by an intriguing process in which residual larval oblique muscles (LOMs) split and fuse with imaginal myoblasts associated with the wing disc...

Detail Information

Publications97

  1. Schneider M, Troost T, Grawe F, Martinez Arias A, Klein T. Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome. J Cell Sci. 2013;126:645-56 pubmed publisher
    The tumour suppressor Lethal (2) giant discs (Lgd) is a regulator of endosomal trafficking of the Notch signalling receptor as well as other transmembrane proteins in Drosophila...
  2. Ni J, Zhou R, Czech B, Liu L, Holderbaum L, Yang Zhou D, et al. A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods. 2011;8:405-7 pubmed publisher
    ..We show that shRNAs, modeled on an endogenous microRNA, are extremely effective at silencing gene expression during oogenesis. We also describe our progress toward building a genome-wide shRNA resource. ..
  3. Yousefian J, Troost T, Grawe F, Sasamura T, FORTINI M, Klein T. Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila. J Cell Sci. 2013;126:1583-94 pubmed publisher
    ..The enlarged endosomes contain Notch and other trans-membrane proteins as cargo...
  4. Nagaraj R, Banerjee U. Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway. EMBO J. 2009;28:337-46 pubmed publisher
    Spatial and temporal control of Notch and Wingless (Wg) pathways during development is regulated at multiple levels. Here, we present an analysis of Phyllopod as a coordinated regulator of these two critical signal transduction pathways...
  5. Truman J, Moats W, Altman J, Marin E, Williams D. Role of Notch signaling in establishing the hemilineages of secondary neurons in Drosophila melanogaster. Development. 2010;137:53-61 pubmed publisher
    ..Using both loss-of-function and gain-of-function approaches, we examined the role of Notch signaling in establishing neuronal fates within all of the thoracic secondary lineages...
  6. Lubensky D, Pennington M, Shraiman B, Baker N. A dynamical model of ommatidial crystal formation. Proc Natl Acad Sci U S A. 2011;108:11145-50 pubmed publisher
    ..We observed these stripes experimentally after manipulation of the Notch and scabrous genes...
  7. Hsu H, Drummond Barbosa D. Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands. Dev Biol. 2011;350:290-300 pubmed publisher
    ..Insulin-like peptides are required for maintenance of cap cells (a major component of the niche) via modulation of Notch signaling, and they also control attachment of GSCs to cap cells and E-cadherin levels at the cap cell-GSC ..
  8. Lin G, Xu N, Xi R. Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells. J Mol Cell Biol. 2010;2:37-49 pubmed publisher
    ..Together with the functional analysis with Notch (N), we suggest two separate roles of JAK/STAT signaling in Drosophila ISC lineages: it functions upstream of N, ..
  9. Li X, Erclik T, Bertet C, Chen Z, Voutev R, Venkatesh S, et al. Temporal patterning of Drosophila medulla neuroblasts controls neural fates. Nature. 2013;498:456-62 pubmed publisher
    ..We provide evidence that this temporal sequence in neuroblasts, together with Notch-dependent binary fate choice, controls the diversification of the neuronal progeny...
  10. Soler C, Taylor M. The Him gene inhibits the development of Drosophila flight muscles during metamorphosis. Mech Dev. 2009;126:595-603 pubmed publisher
    ..They are formed by an intriguing process in which residual larval oblique muscles (LOMs) split and fuse with imaginal myoblasts associated with the wing disc...
  11. Benhra N, Lallet S, Cotton M, Le Bras S, Dussert A, Le Borgne R. AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors. Curr Biol. 2011;21:87-95 pubmed publisher
    ..The SOP divides asymmetrically to generate daughter cells, whose fates are governed by differential Notch activation...
  12. Guichard A, McGillivray S, Cruz Moreno B, van Sorge N, Nizet V, Bier E. Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Nature. 2010;467:854-8 pubmed publisher
    ..Convergent effects of EF and LF on Rab11/Sec15 inhibit expression of and signalling by the Notch ligand Delta and reduce DE-cadherin levels at adherens junctions...
  13. Wesley C, Guo H, Chaudhry K, THALI M, Yin J, Clason T, et al. Loss of PTB or negative regulation of Notch mRNA reveals distinct zones of Notch and actin protein accumulation in Drosophila embryo. PLoS ONE. 2011;6:e21876 pubmed publisher
    ..bristle development during the post-embryonic stages of Drosophila suggest that it is a negative regulator of the Notch pathway. How PTB regulates the Notch pathway is unknown...
  14. Karbowniczek M, Zitserman D, Khabibullin D, Hartman T, Yu J, Morrison T, et al. The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. J Clin Invest. 2010;120:93-102 pubmed publisher
    ..In normal development, the sensory organ precursor cell divides asymmetrically through differential regulation of Notch signaling to produce a pIIa and a pIIb cell...
  15. Bernard F, Krejci A, Housden B, Adryan B, Bray S. Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. Development. 2010;137:2633-42 pubmed publisher
    Cell-cell signalling mediated by Notch regulates many different developmental and physiological processes and is involved in a variety of human diseases...
  16. Nystul T, Spradling A. Regulation of epithelial stem cell replacement and follicle formation in the Drosophila ovary. Genetics. 2010;184:503-15 pubmed publisher
    ..Instead, key intercellular signals begin early and guide cell behavior. An initial Notch signal from germ cells is required for FSC daughters to migrate across the ovariole and on occasion to replace the ..
  17. Matsuno M, Horiuchi J, Tully T, Saitoe M. The Drosophila cell adhesion molecule klingon is required for long-term memory formation and is regulated by Notch. Proc Natl Acad Sci U S A. 2009;106:310-5 pubmed publisher
    ..LTM formation also requires activity of the Notch cell-surface receptor...
  18. Zeng X, Lin X, Hou S. The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine. Development. 2013;140:3532-40 pubmed publisher
    ..We further demonstrated that Osa regulates ISC self-renewal and differentiation into enterocytes by elaborating Notch signaling, and ISC commitment to differentiation into EE cells by regulating the expression of Asense, an EE cell ..
  19. Leong G, Goulding K, Amin N, Richardson H, Brumby A. Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs. BMC Biol. 2009;7:62 pubmed publisher
    ..JNK normally promotes apoptosis of scrib mutant cells. However, in cooperation with oncogenic activated Ras or Notch signalling, JNK becomes an essential driver of tumour overgrowth and invasion...
  20. Herz H, Madden L, Chen Z, Bolduc C, Buff E, Gupta R, et al. The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol. 2010;30:2485-97 pubmed publisher
    ..The growth advantage of dUTX mutant tissue is caused, at least in part, by increased Notch activity, demonstrating that dUTX is a Notch antagonist...
  21. Yang S, Wang W, Chen C, Tseng C, Chen Y, Hsu H. FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency. Dev Biol. 2013;382:124-35 pubmed publisher
    ..Nutrient-sensing insulin/FOXO signaling has been previously shown to directly control Notch activation in the Drosophila female germline stem cell (GSC) niche, which maintains the niche and GSC identity...
  22. Das A, Reichert H, Rodrigues V. Notch regulates the generation of diverse cell types from the lateral lineage of Drosophila antennal lobe. J Neurogenet. 2010;24:42-53 pubmed publisher
    ..The authors show that loss of Notch function from the entire lineage during development leads to an absence of local interneurons (LNs) with a ..
  23. Xiao Q, Komori H, Lee C. klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division. Development. 2012;139:2670-80 pubmed publisher
    ..In larval brains lacking brain tumor function or exhibiting constitutively activated Notch signaling, removal of klu function prevents the reversion of immature INPs...
  24. Lee T, Sethi M, Leonardi J, Rana N, Buettner F, Haltiwanger R, et al. Negative regulation of notch signaling by xylose. PLoS Genet. 2013;9:e1003547 pubmed publisher
    The Notch signaling pathway controls a large number of processes during animal development and adult homeostasis...
  25. Kunttas Tatli E, Bose A, Kahali B, Bishop C, Bidwai A. Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis. Genesis. 2009;47:647-58 pubmed publisher
    Repression by E(spl)M8 during inhibitory Notch (N) signaling (lateral inhibition) is regulated, in part, by protein kinase CK2, but the involvement of a phosphatase has been unclear...
  26. Guarner A, Manjón C, Edwards K, Steller H, Suzanne M, Sánchez Herrero E. The zinc finger homeodomain-2 gene of Drosophila controls Notch targets and regulates apoptosis in the tarsal segments. Dev Biol. 2014;385:350-65 pubmed publisher
    ..One of the main pathways needed for leg development is the Notch pathway, required for determining the proximo-distal axis of the leg and for the formation of the joints that ..
  27. Coumailleau F, Fürthauer M, Knoblich J, Gonzalez Gaitan M. Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division. Nature. 2009;458:1051-5 pubmed publisher
    Endocytosis has a crucial role during Notch signalling after the asymmetric division of fly sensory organ precursors (SOPs): directional signalling is mediated by differential endocytosis of the ligand Delta and the Notch effector ..
  28. Fiuza U, Klein T, Martinez Arias A, Hayward P. Mechanisms of ligand-mediated inhibition in Notch signaling activity in Drosophila. Dev Dyn. 2010;239:798-805 pubmed publisher
    The transmembrane proteins Delta and Serrate act as ligands for the signaling receptor Notch. In addition to this activating role, Delta and Serrate can also inhibit Notch signaling activity...
  29. Chen H, Wang C, Wang T, Liaw G, Hsu T, Lin T, et al. The Hippo pathway controls polar cell fate through Notch signaling during Drosophila oogenesis. Dev Biol. 2011;357:370-9 pubmed publisher
    ..Multiple signaling cascades coordinate to control the follicle cell fate determination, including Notch, JAK/STAT, and Hedgehog signaling pathways...
  30. Bejarano F, Bortolamiol Becet D, Dai Q, Sun K, Saj A, Chou Y, et al. A genome-wide transgenic resource for conditional expression of Drosophila microRNAs. Development. 2012;139:2821-31 pubmed publisher
    ..Whereas misexpression of several K box miRNAs inhibited Notch pathway activity, reciprocal genetic interaction tests with miRNA sponges demonstrated endogenous roles of the K ..
  31. Harris K, Tepass U. Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis. J Cell Biol. 2008;183:1129-43 pubmed publisher
    ..This study reveals functional interactions between apical polarity proteins and endocytosis that are critical for stabilizing dynamic basolateral AJs. ..
  32. Zacharioudaki E, Magadi S, Delidakis C. bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation. Development. 2012;139:1258-69 pubmed publisher
    ..Expression of E(spl)m? and m8, but not of dpn, depends on Notch signalling from the GMC/INP daughter to the NB...
  33. Rouault H, Mazouni K, Couturier L, Hakim V, Schweisguth F. Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny. Proc Natl Acad Sci U S A. 2010;107:14615-20 pubmed publisher
    ..The statistics and phylogeny-based tools described here can be more generally applied to identify the cis-regulatory elements of specific gene regulatory networks in any family of related species with sequenced genomes. ..
  34. Terriente Félix A, Li J, Collins S, Mulligan A, Reekie I, Bernard F, et al. Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme. Development. 2013;140:926-37 pubmed publisher
    The diverse functions of Notch signalling imply that it must elicit context-specific programmes of gene expression...
  35. Robinson B, Huang J, Hong Y, Moberg K. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol. 2010;20:582-90 pubmed publisher
  36. Gutierrez Aviño F, Ferres Marco D, Dominguez M. The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed. EMBO Rep. 2009;10:1051-8 pubmed publisher
    ..In the Drosophila eye, local Notch activation establishes a conserved dorsal-ventral organizer that promotes growth...
  37. Leonardi J, Fernandez Valdivia R, Li Y, SIMCOX A, Jafar Nejad H. Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Development. 2011;138:3569-78 pubmed publisher
    Mutations in Drosophila rumi result in a temperature-sensitive loss of Notch signaling. Rumi is a protein O-glucosyltransferase that adds glucose to EGF repeats with a C-X-S-X-P-C consensus sequence...
  38. de Navascués J, Perdigoto C, Bian Y, Schneider M, Bardin A, Martinez Arias A, et al. Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells. EMBO J. 2012;31:2473-85 pubmed publisher
  39. Zhu S, Wildonger J, Barshow S, Younger S, Huang Y, Lee T. The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch. PLoS ONE. 2012;7:e46724 pubmed publisher
    ..Our results also show that knockdown of Notch leads to ectopic Ase expression in type II NBs and the premature loss of type II NBs...
  40. Shepherd A, Singh R, Wesley C. Notch mRNA expression in Drosophila embryos is negatively regulated at the level of mRNA 3' processing. PLoS ONE. 2009;4:e8063 pubmed publisher
    b>Notch receptor regulates differentiation of almost all tissues and organs during animal development. Many mechanisms function at the protein level to finely regulate Notch activity...
  41. Bernard F, Kasherov P, Grenetier S, Dutriaux A, Zider A, Silber J, et al. Integration of differentiation signals during indirect flight muscle formation by a novel enhancer of Drosophila vestigial gene. Dev Biol. 2009;332:258-72 pubmed publisher
    ..We show here that vg is controlled by the Notch anti-myogenic signaling pathway in myoblasts and is regulated by a novel 822 bp enhancer during IFM ..
  42. Babaoglan A, Housden B, Furriols M, Bray S. Deadpan contributes to the robustness of the notch response. PLoS ONE. 2013;8:e75632 pubmed publisher
    ..Its targets include genes of the bHLH hairy and Enhancer of split [E(spl)] family, which contribute to many of these developmental decisions...
  43. Boukhatmi H, Frendo J, Enriquez J, Crozatier M, Dubois L, Vincent A. Tup/Islet1 integrates time and position to specify muscle identity in Drosophila. Development. 2012;139:3572-82 pubmed publisher
    ..The contributions of Tin, Tup and Col to patterning Drosophila dorsal muscles bring novel parallels with chordate pharyngeal muscle development. ..
  44. Ngo K, Wang J, Junker M, Kriz S, Vo G, Asem B, et al. Concomitant requirement for Notch and Jak/Stat signaling during neuro-epithelial differentiation in the Drosophila optic lobe. Dev Biol. 2010;346:284-95 pubmed publisher
    ..reconstructed the complex morphogenesis of the optic lobe during the larval period, and established a role for the Notch and Jak/Stat signaling pathways during the NE-NB conversion...
  45. Herz H, Woodfield S, Chen Z, Bolduc C, Bergmann A. Common and distinct genetic properties of ESCRT-II components in Drosophila. PLoS ONE. 2009;4:e4165 pubmed publisher
    ..In Drosophila, mutations of the ESCRT-II component vps25 cause endosomal defects leading to accumulation of Notch protein and increased Notch pathway activity...
  46. Perdigoto C, Schweisguth F, Bardin A. Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine. Development. 2011;138:4585-95 pubmed publisher
    ..e. exit from self-renewal, and terminal differentiation are controlled by Notch signaling...
  47. Kandachar V, Roegiers F. Endocytosis and control of Notch signaling. Curr Opin Cell Biol. 2012;24:534-40 pubmed publisher
    The Notch signaling pathway controls patterning and cell fate decisions during development in metazoans, and is associated with human diseases such as cerebral autosomal dominant arteriopathy with subcortical infarcts and ..
  48. Kapuria S, Karpac J, Biteau B, Hwangbo D, Jasper H. Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS Genet. 2012;8:e1003045 pubmed publisher
    ..EBs) that differentiate into either enterocytes (ECs) or enteroendocrine cells (EEs) in response to differential Notch (N) activation...
  49. Cook R, Deal M, Deal J, Garton R, Brown C, Ward M, et al. A new resource for characterizing X-linked genes in Drosophila melanogaster: systematic coverage and subdivision of the X chromosome with nested, Y-linked duplications. Genetics. 2010;186:1095-109 pubmed publisher
    ..These duplication chromosomes will be valuable resources for rescuing and mapping X-linked mutations and identifying dosage-dependent modifiers of mutant phenotypes. ..
  50. Orihara Ono M, Toriya M, Nakao K, Okano H. Downregulation of Notch mediates the seamless transition of individual Drosophila neuroepithelial progenitors into optic medullar neuroblasts during prolonged G1. Dev Biol. 2011;351:163-75 pubmed publisher
    ..We also found that Notch signaling pathway was activated just before the transition and was rapidly downregulated...
  51. Olivieri D, Sykora M, Sachidanandam R, Mechtler K, Brennecke J. An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J. 2010;29:3301-17 pubmed publisher
    ..Loss of Zucchini leads to an accumulation of Piwi and Armitage in Yb bodies, indicating that Yb bodies are sites of primary piRNA biogenesis. ..
  52. Kahali B, Bose A, Karandikar U, Bishop C, Bidwai A. On the mechanism underlying the divergent retinal and bristle defects of M8* (E(spl)D) in Drosophila. Genesis. 2009;47:456-68 pubmed publisher
    ..using endogenous mutants and Gal4-UAS driven transgenes, implicate multisite phosphorylation in repression by E(spl)M8...
  53. Nagel A, Preiss A. Fine tuning of Notch signaling by differential co-repressor recruitment during eye development of Drosophila. Hereditas. 2011;148:77-84 pubmed publisher
    b>Notch signaling is fundamental to the regulation of cellular differentiation, cell growth and cell death in mammals as well as in invertebrates like Drosophila...
  54. Whiteman P, de Madrid B, Taylor P, Li D, Heslop R, Viticheep N, et al. Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor. J Biol Chem. 2013;288:7305-12 pubmed publisher
    ..We have mapped a Jagged/Serrate-binding site to specific residues within the 12th EGF domain of human and Drosophila Notch. Two critical residues, involved in a hydrophobic interaction, provide a ligand-binding platform and are adjacent ..
  55. Kahali B, Kim J, Karandikar U, Bishop C, Bidwai A. Evidence that the C-terminal domain (CtD) autoinhibits neural repression by Drosophila E(spl)M8. Genesis. 2010;48:44-55 pubmed publisher
    Analysis of the retinal defects of a CK2 phosphomimetic variant of E(spl)M8 (M8S(159)D) and the truncated protein M8* encoded by the E(spl)D allele, suggest that the nonphosphorylated CtD "autoinhibits" repression...
  56. Yamamoto S, Charng W, Rana N, Kakuda S, Jaiswal M, Bayat V, et al. A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands. Science. 2012;338:1229-32 pubmed publisher
    b>Notch signaling affects many developmental and cellular processes and has been implicated in congenital disorders, stroke, and numerous cancers...
  57. Boggiano J, Vanderzalm P, Fehon R. Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. Dev Cell. 2011;21:888-95 pubmed publisher
    ..These results demonstrate that one family of Ste20 kinases can activate another and identify Tao-1 as a component of the regulatory network controlling HSW pathway signaling, and therefore tissue growth, during development. ..
  58. Shepherd A, Wesley U, Wesley C. Notch and delta mRNAs in early-stage and mid-stage drosophila embryos exhibit complementary patterns of protein-producing potentials. Dev Dyn. 2010;239:1220-33 pubmed publisher
    b>Notch and Delta proteins generate Notch signaling that specifies cell fates during animal development...
  59. Sprinzak D, Lakhanpal A, Lebon L, Garcia Ojalvo J, Elowitz M. Mutual inactivation of Notch receptors and ligands facilitates developmental patterning. PLoS Comput Biol. 2011;7:e1002069 pubmed publisher
    ..Recent work has shown that Notch and Delta, the canonical metazoan juxtacrine signaling receptor and ligand, mutually inactivate each other in the ..
  60. Zhou D, Udpa N, Gersten M, Visk D, Bashir A, Xue J, et al. Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011;108:2349-54 pubmed publisher
    ..Several of the hypoxia-selected regions contained genes encoding or regulating the Notch pathway...
  61. San Juán B, Baonza A. The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila. Dev Biol. 2011;352:70-82 pubmed publisher
    ..The Notch signaling pathway has long been known to influence cell fate decisions during development...
  62. Rajan A, Tien A, Haueter C, Schulze K, Bellen H. The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol. 2009;11:815-24 pubmed publisher
    Cell fate decisions mediated by the Notch signalling pathway require direct cell-cell contact between adjacent cells...
  63. Cruz C, Glavic A, Casado M, de Celis J. A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wing. Genetics. 2009;183:1005-26 pubmed publisher
    ..Finally, we present a preliminary characterization of a gene identified in the screen, the function of which is required for the development of the L5 longitudinal vein. ..
  64. Singh J, Mlodzik M. Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages. Dev Cell. 2012;23:82-96 pubmed publisher
    ..Here, we uncover a role of Hbs in Notch (N) signaling and ?-secretase processing...
  65. Lee G, Liang C, Park G, Jang C, Jung J, Chung J. UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila. Dev Biol. 2011;356:588-97 pubmed publisher
    ..Blunted endocytic degradation by UVRAG deficiency causes endosomal accumulation of Notch, resulting in abnormally enhanced Notch activity...
  66. Egger B, Gold K, Brand A. Notch regulates the switch from symmetric to asymmetric neural stem cell division in the Drosophila optic lobe. Development. 2010;137:2981-7 pubmed publisher
    ..We find genes encoding members of the Notch pathway expressed in neuroepithelial cells...
  67. Hori K, Sen A, Kirchhausen T, Artavanis Tsakonas S. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol. 2011;195:1005-15 pubmed publisher
    The Notch signaling pathway defines a conserved mechanism that regulates cell fate decisions in metazoans. Signaling is modulated by a broad and multifaceted genetic circuitry, including members of the endocytic machinery...
  68. Kobia F, Duchi S, Deflorian G, Vaccari T. Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling. Mol Oncol. 2014;8:207-20 pubmed publisher
    b>Notch signaling in prominently involved in growth regulation in metazoan tissues. Because of this, Notch is often upregulated in cancer and current efforts point to developing drugs that block its activation...
  69. Wang W, Liu W, Wang Y, Zhou L, Tang X, Luo H. Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. Dev Biol. 2011;350:414-28 pubmed publisher
    b>Notch signaling mediates multiple developmental decisions in Drosophila. In this study, we have examined the role of Notch signaling in Drosophila larval optic lobe development...
  70. Ni J, Liu L, Binari R, Hardy R, Shim H, Cavallaro A, et al. A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics. 2009;182:1089-100 pubmed publisher
  71. Vaccari T, Duchi S, Cortese K, Tacchetti C, Bilder D. The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development. 2010;137:1825-32 pubmed publisher
    Evidence indicates that endosomal entry promotes signaling by the Notch receptor, but the mechanisms involved are not clear...
  72. Akbar M, Ray S, KRAMER H. The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles. Mol Biol Cell. 2009;20:1705-14 pubmed publisher
    ..Consistent with a role in Car-mediated fusion, dSyntaxin16 is not restricted to Golgi membranes but also present on lysosomes. ..
  73. Monastirioti M, Giagtzoglou N, Koumbanakis K, Zacharioudaki E, Deligiannaki M, Wech I, et al. Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis. Development. 2010;137:191-201 pubmed publisher
    ..Hes proteins are often effectors of Notch signalling...
  74. Apidianakis Y, Rahme L. Drosophila melanogaster as a model for human intestinal infection and pathology. Dis Model Mech. 2011;4:21-30 pubmed publisher
    ..In this Perspective, we discuss recent advances in the study of Drosophila intestinal infection and pathology, and briefly review the parallels and differences between human and Drosophila intestinal regeneration and disease. ..
  75. Hsu H, Drummond Barbosa D. Insulin levels control female germline stem cell maintenance via the niche in Drosophila. Proc Natl Acad Sci U S A. 2009;106:1117-21 pubmed publisher
    ..of diet and age on germline stem cell (GSC) maintenance through the dual regulation of cap cell number (via Notch signaling) and cap cell-GSC interaction (via E-cadherin) and that the normal process of GSC and niche cell loss ..
  76. Liu W, Singh S, Hou S. JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells. J Cell Biochem. 2010;109:992-9 pubmed publisher
    ..b>Notch signaling has dual functions to control ISC behavior: it slows down the ISC proliferation and drives the activated ..
  77. Mathur D, Bost A, Driver I, Ohlstein B. A transient niche regulates the specification of Drosophila intestinal stem cells. Science. 2010;327:210-3 pubmed publisher
    ..Here, we show that an ISC progenitor generates a niche cell via Notch signaling...
  78. Goulas S, Conder R, Knoblich J. The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells. Cell Stem Cell. 2012;11:529-40 pubmed publisher
    ..Cell-specific knockdown and overexpression experiments suggest that increased activity of aPKC enhances Delta/Notch signaling in one of the two daughter cells to induce terminal differentiation...
  79. Fontana J, Posakony J. Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta. Dev Biol. 2009;333:373-85 pubmed publisher
    Lateral inhibition is one of the key functions of Notch signaling during animal development...
  80. Becam I, Fiuza U, Arias A, Milan M. A role of receptor Notch in ligand cis-inhibition in Drosophila. Curr Biol. 2010;20:554-60 pubmed publisher
    b>Notch and its ligands mediate short-range cell interactions that play a conserved role in inducing cell fate specification...
  81. Barad O, Rosin D, Hornstein E, Barkai N. Error minimization in lateral inhibition circuits. Sci Signal. 2010;3:ra51 pubmed publisher
    ..Cell-autonomous interactions (cis interactions) between the Notch receptor and its ligands Delta or Serrate facilitate accurate SOP selection by shortening the effective delay ..
  82. Vied C, Kalderon D. Hedgehog-stimulated stem cells depend on non-canonical activity of the Notch co-activator Mastermind. Development. 2009;136:2177-86 pubmed publisher
    ..We have used a genetic screen to identify Mastermind (Mam), the Notch pathway transcriptional co-activator, as a rare dose-dependent modifier of aberrant FSC expansion induced by ..
  83. Mukai A, Yamamoto Hino M, Awano W, Watanabe W, Komada M, Goto S. Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt. EMBO J. 2010;29:2114-25 pubmed publisher
    ..These results unveil a novel mechanism that regulates the cellular responsiveness to Wg/Wnt by controlling the cell surface level of Frizzled. ..
  84. Babaoglan A, O Connor Giles K, Mistry H, Schickedanz A, Wilson B, Skeath J. Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions. Development. 2009;136:4089-98 pubmed publisher
    ..Antagonistic interactions between the Notch pathway and the intrinsic cell-fate determinant Numb appear to regulate asymmetric divisions in flies and ..
  85. Biteau B, Karpac J, Supoyo S, Degennaro M, Lehmann R, Jasper H. Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genet. 2010;6:e1001159 pubmed publisher
    ..These include reduced Insulin/IGF or Jun-N-terminal Kinase (JNK) signaling activities, as well as over-expression of stress-protective genes in somatic stem ..
  86. Nicholson S, Nicolay B, Frolov M, Moberg K. Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development. 2011;138:251-60 pubmed publisher
    ..of ago mRNA and protein is induced by passage of the morphogenetic furrow (MF) and identify the hedgehog (hh) and Notch (N) pathways as elements of this inductive mechanism...
  87. Richardson E, Pichaud F. Crumbs is required to achieve proper organ size control during Drosophila head development. Development. 2010;137:641-50 pubmed publisher
    ..eye, this is caused by an increase in cell proliferation that can be attributed to an increase in ligand-dependent Notch (N) signalling...
  88. Kawahashi K, Hayashi S. Dynamic intracellular distribution of Notch during activation and asymmetric cell division revealed by functional fluorescent fusion proteins. Genes Cells. 2010;15:749-59 pubmed publisher
    b>Notch signaling mediates intercellular communication required for cell fate specification...
  89. Pueyo J, Couso J. Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor. Dev Biol. 2011;355:183-93 pubmed publisher
    The formation of signalling boundaries is one of the strategies employed by the Notch (N) pathway to give rise to two distinct signalling populations of cells...
  90. Weng M, Golden K, Lee C. dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila. Dev Cell. 2010;18:126-35 pubmed publisher
    ..the potential of intermediate neural progenitors by activating Prospero to limit proliferation and by antagonizing Notch signaling to prevent dedifferentiation...
  91. Wang Y, Chen Z, Bergmann A. Regulation of EGFR and Notch signaling by distinct isoforms of D-cbl during Drosophila development. Dev Biol. 2010;342:1-10 pubmed publisher
    ..Here, we report that D-Cbl also negatively regulates Notch activity during eye and wing development. D-cbl produces two isoforms by alternative splicing...
  92. Banks S, Cho B, Eun S, Lee J, Windler S, Xie X, et al. The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. PLoS ONE. 2011;6:e18259 pubmed publisher
    b>Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling...
  93. Cohen M, Georgiou M, Stevenson N, Miodownik M, Baum B. Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition. Dev Cell. 2010;19:78-89 pubmed publisher
    ..During this process, membrane-tethered Delta activates intracellular Notch signaling in neighboring epithelial cells, which inhibits Delta expression...
  94. Lee W, Beebe K, Sudmeier L, Micchelli C. Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation. Development. 2009;136:2255-64 pubmed publisher
    ..Together, these data underscore the essential requirement of Apc in exerting regulatory control over stem cell activity, as well as the consequences that disrupting this regulation can have on tissue homeostasis. ..
  95. Stempfle D, Kanwar R, Loewer A, Fortini M, Merdes G. In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol Cell Biol. 2010;30:3165-75 pubmed publisher
    ..different substrates, including markedly reduced cleavage of some APP family members compared to cleavage of the Notch receptor...
  96. Djiane A, Shimizu H, Wilkin M, Mazleyrat S, Jennings M, Avis J, et al. Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue. J Cell Biol. 2011;192:189-200 pubmed publisher
    ..Drosophila melanogaster ZO homologue, regulates accumulation of adherens junction-localized receptors, such as Notch, although it is dispensable for epithelial polarization...