Myc

Summary

Gene Symbol: Myc
Description: Myc
Alias: CG10798, D-Myc, DMYc, Dmel\CG10798, Dmyc, EG:BACN5I9.1, MYC, anon-WO03040301.171, bHLHe57, c-MYC, c-Myc, c-myc, d-myc, dMYC, dMyc, dMyc1, dm/dMyc, dm/myc, dmyc, dmyc1, l(1)G0139, l(1)G0354, l(1)G0359, myc, Myc, CG10798-PA, CG10798-PB, Myc-PA, Myc-PB, diminuitive, diminutive, lethal (1) G0354, lethal (1) G0359
Species: fruit fly
Products:     Myc

Top Publications

  1. Maines J, Stevens L, Tong X, Stein D. Drosophila dMyc is required for ovary cell growth and endoreplication. Development. 2004;131:775-86 pubmed
    ..We have initiated a genetic analysis of the Drosophila homolog of the Myc oncoprotein (dMyc), which is encoded by the dm locus...
  2. de la Cova C, Abril M, Bellosta P, Gallant P, Johnston L. Drosophila myc regulates organ size by inducing cell competition. Cell. 2004;117:107-16 pubmed
    ..We show that local expression of the Drosophila growth regulator dMyc, a homolog of the c-myc protooncogene, induces cell competition and leads to the death of nearby wild-type cells in ..
  3. Benassayag C, Montero L, Colombié N, Gallant P, Cribbs D, Morello D. Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster. Mol Cell Biol. 2005;25:9897-909 pubmed
    ..First, we established that the human c-Myc protein can rescue lethal mutations of the Drosophila myc ortholog, dmyc, demonstrating the biological relevance of this model...
  4. Chen C, Schroeder M, Kango Singh M, Tao C, Halder G. Tumor suppression by cell competition through regulation of the Hippo pathway. Proc Natl Acad Sci U S A. 2012;109:484-9 pubmed publisher
    ..Thus, cell competition acts as a tumor-suppressing mechanism by regulating the Hippo pathway in scrib(-) cells. ..
  5. Froldi F, Ziosi M, Garoia F, Pession A, Grzeschik N, Bellosta P, et al. The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. BMC Biol. 2010;8:33 pubmed publisher
    ..Furthermore, they express very low levels of dMyc oncoprotein compared with those found in the surrounding normal tissue...
  6. Rhiner C, Diaz B, Portela M, Poyatos J, Fernández Ruíz I, López Gay J, et al. Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche. Development. 2009;136:995-1006 pubmed publisher
    ..Drosophila Myc (dMyc; Dm-FlyBase) is a potent inducer of cell competition in wing epithelia, but its role in the ovary germline stem ..
  7. Fernández Hernández I, Rhiner C, Moreno E. Adult neurogenesis in Drosophila. Cell Rep. 2013;3:1857-65 pubmed publisher
    ..Our results reveal unexpected plasticity in the adult Drosophila brain and describe a unique model for the genetic analysis of adult neurogenesis, plasticity, and brain regeneration. ..
  8. Menendez J, Pérez Garijo A, Calleja M, Morata G. A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway. Proc Natl Acad Sci U S A. 2010;107:14651-6 pubmed publisher
    ..The formation of a tumor requires in addition the formation of a microenvironment that allows mutant cells to evade cell competition. ..
  9. Galletti M, Riccardo S, Parisi F, Lora C, Saqcena M, Rivas L, et al. Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases. Mol Cell Biol. 2009;29:3424-34 pubmed publisher
    In the present study, we report that ubiquitin-mediated degradation of dMyc, the Drosophila homologue of the human c-myc proto-oncogene, is regulated in vitro and in vivo by members of the casein kinase 1 (CK1) family and by glycogen ..

More Information

Publications80

  1. Furrer M, Balbi M, Albarca Aguilera M, Gallant M, Herr W, Gallant P. Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth. J Biol Chem. 2010;285:39623-36 pubmed publisher
    The Myc proto-oncoproteins are transcription factors that recognize numerous target genes through hexameric DNA sequences called E-boxes. The mechanism by which they then activate the expression of these targets is still under debate...
  2. Moreno E, Basler K. dMyc transforms cells into super-competitors. Cell. 2004;117:117-29 pubmed
    ..show that this invariably elicits a win/lose situation reminiscent of cell competition; cells with lower levels of dMyc are eliminated by apoptosis whereas cells with higher levels of dMyc over-proliferate...
  3. Herranz H, Perez L, Martín F, Milan M. A Wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing. EMBO J. 2008;27:1633-45 pubmed publisher
    ..We present evidence that these molecules exert their function by regulating the expression of the dmyc proto-oncogene and the bantam micro-RNA, which positively modulated the activity of the E2F transcription factor...
  4. Amcheslavsky A, Ito N, Jiang J, Ip Y. Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells. J Cell Biol. 2011;193:695-710 pubmed publisher
    ..Slowing the growth by feeding rapamycin or reducing Myc was sufficient to rescue the division defect...
  5. Jin Z, Kirilly D, Weng C, Kawase E, Song X, Smith S, et al. Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell. 2008;2:39-49 pubmed publisher
  6. Herranz H, Hong X, Perez L, Ferreira A, Olivieri D, Cohen S, et al. The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. EMBO J. 2010;29:1688-98 pubmed publisher
    ..We present evidence that Dcr-1 acts by regulating the TRIM-NHL protein Mei-P26, which in turn regulates dMyc protein levels. Mei-P26 is a direct target of miRNAs, including the growth-promoting bantam miRNA...
  7. Senoo Matsuda N, Johnston L. Soluble factors mediate competitive and cooperative interactions between cells expressing different levels of Drosophila Myc. Proc Natl Acad Sci U S A. 2007;104:18543-8 pubmed
    When neighboring cells in the developing Drosophila wing express different levels of the transcription factor, dMyc, competitive interactions can occur...
  8. Vincent J, Kolahgar G, Gagliardi M, Piddini E. Steep differences in wingless signaling trigger Myc-independent competitive cell interactions. Dev Cell. 2011;21:366-74 pubmed publisher
    ..This process does not involve Myc, a well-established cell competition factor...
  9. Harris R, Pargett M, Sutcliffe C, Umulis D, Ashe H. Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signaling. Dev Cell. 2011;20:72-83 pubmed publisher
    ..GSCs by Pum-Nos but functions with Pum in CBs to translationally repress distinct targets, including the Mad and dMyc mRNAs...
  10. Hulf T, Bellosta P, Furrer M, Steiger D, Svensson D, Barbour A, et al. Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes. Mol Cell Biol. 2005;25:3401-10 pubmed
    ..a comprehensive analysis of the transcriptional targets of the sole Myc ortholog in Drosophila melanogaster, dMyc. We show that the genes that are down-regulated in response to dmyc inhibition are largely identical to those that ..
  11. Quinn L, Dickins R, Coombe M, Hime G, Bowtell D, Richardson H. Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation. Development. 2004;131:1411-23 pubmed
    ..Hfp negatively regulates dmyc expression and function, as reducing the dose of hfp increases levels of dmyc mRNA and rescues defective oogenesis ..
  12. Carney T, Miller M, Robinson K, Bayraktar O, Osterhout J, Doe C. Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis. Dev Biol. 2012;361:137-46 pubmed publisher
    ..These genes are excellent candidates for regulating neural progenitor self-renewal in Drosophila and mammals. ..
  13. Li L, Edgar B, Grewal S. Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element. BMC Cell Biol. 2010;11:7 pubmed publisher
    ..We did however identify a strong overlap between genes regulated by the transcription factor, Myc, and AA starvation-responsive genes, particularly those involved in ribosome biogenesis, protein synthesis and ..
  14. Lecuit T, Le Goff L. Orchestrating size and shape during morphogenesis. Nature. 2007;450:189-92 pubmed
    ..New models integrate how specific signals and mechanical forces shape tissues and may also control their size. ..
  15. Tamori Y, Deng W. Tissue repair through cell competition and compensatory cellular hypertrophy in postmitotic epithelia. Dev Cell. 2013;25:350-63 pubmed publisher
  16. Prober D, Edgar B. Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev. 2002;16:2286-99 pubmed
    ..Here, we present evidence indicating that Ras(V12) promotes cell growth and G(1)/S progression by increasing dMyc protein levels and activating dPI3K signaling, and that it does so via separate effector pathways...
  17. Schreiber Agus N, Stein D, Chen K, Goltz J, Stevens L, DePinho R. Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. Proc Natl Acad Sci U S A. 1997;94:1235-40 pubmed
    ..ectopic expression of dmyc1 to reverse a subset of the phenotypic alterations associated with the diminutive mutation suggests that diminutive may correspond to dmyc1...
  18. Marshall L, Rideout E, Grewal S. Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila. EMBO J. 2012;31:1916-30 pubmed publisher
    ..in growing larvae via inhibition of the repressor Maf1 and, in part, via the transcription factor Drosophila Myc (dMyc)...
  19. Britton J, Lockwood W, Li L, Cohen S, Edgar B. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev Cell. 2002;2:239-49 pubmed
    ..Hence we surmise that an essential function of insulin/PI3K signaling in Drosophila is to coordinate cellular metabolism with nutritional conditions. ..
  20. Marinho J, Casares F, Pereira P. The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth. Development. 2011;138:349-57 pubmed publisher
    ..We further show that viriato expression is controlled by Drosophila Myc (dMyc), and that the ability of dMyc to stimulate nucleolar and cellular growth depends on viriato expression...
  21. Johnston L, Prober D, Edgar B, Eisenman R, Gallant P. Drosophila myc regulates cellular growth during development. Cell. 1999;98:779-90 pubmed
    ..Here we address the functions of Drosophila Myc (dMyc) during development...
  22. Ziosi M, Baena Lopez L, Grifoni D, Froldi F, Pession A, Garoia F, et al. dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells. PLoS Genet. 2010;6:e1001140 pubmed publisher
    ..Here we provide insight into the mechanism by which the Hpo pathway is linked to cell competition, by identifying dMyc as a target gene of the Hpo pathway, transcriptionally upregulated by the activity of Yki with different binding ..
  23. Neto Silva R, de Beco S, Johnston L. Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap. Dev Cell. 2010;19:507-20 pubmed publisher
    ..Here we demonstrate that the activities of the conserved growth-promoting transcription factor Myc and the tumor-suppressing Hippo pathway are codependent during growth of Drosophila imaginal discs...
  24. Smith Bolton R, Worley M, Kanda H, Hariharan I. Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc. Dev Cell. 2009;16:797-809 pubmed publisher
    ..Wingless and Myc are induced by tissue damage and are important for regenerative growth...
  25. Goodliffe J, Wieschaus E, Cole M. Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila. Genes Dev. 2005;19:2941-6 pubmed
    ..We examined the control of myc in Drosophila and show here that the Drosophila ortholog, dmyc, also undergoes autorepression...
  26. Pierce S, Yost C, Britton J, Loo L, Flynn E, Edgar B, et al. dMyc is required for larval growth and endoreplication in Drosophila. Development. 2004;131:2317-27 pubmed
    ..We have used dm(4), a new null allele of the Drosophila diminutive (dm) gene, which encodes dMyc on the X chromosome, to investigate a role for dMyc in larval endoreplicating ..
  27. Fay A, Misulovin Z, Li J, Schaaf C, Gause M, Gilmour D, et al. Cohesin selectively binds and regulates genes with paused RNA polymerase. Curr Biol. 2011;21:1624-34 pubmed publisher
    ..Our findings argue that cohesin and pausing factors are recruited independently to the same genes, perhaps by GAF and the GT repeats, and that their combined action determines the level of actively elongating RNA polymerase. ..
  28. Kharazmi J, Moshfegh C, Brody T. Identification of cis-Regulatory Elements in the dmyc Gene of Drosophila Melanogaster. Gene Regul Syst Bio. 2012;6:15-42 pubmed publisher
    ..In this study we used Drosophila genetic tools to track the dmyc cis-regulatory elements...
  29. Datar S, Galloni M, de la Cruz A, Marti M, Edgar B, Frei C. Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila. Cell Cycle. 2006;5:647-52 pubmed
    ..Furthermore, Hif-1 prolyl hydroxylase (Hph) is required for both complexes to drive growth. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals. ..
  30. Nagy P, Varga A, Pircs K, Hegedűs K, Juhász G. Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster. PLoS Genet. 2013;9:e1003664 pubmed publisher
    ..Here we show that the evolutionarily conserved transcription factor Myc (dm), a proto-oncogene involved in cell growth and proliferation, is also a physiological regulator of autophagy in ..
  31. Yang J, Sung E, Donlin Asp P, Corces V. A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins. Nat Commun. 2013;4:1464 pubmed publisher
    b>Myc has been characterized as a transcription factor that activates expression of genes involved in pluripotency and cancer, and as a component of the replication complex...
  32. Wang H, Somers G, Bashirullah A, Heberlein U, Yu F, Chia W. Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev. 2006;20:3453-63 pubmed
    ..We have identified a novel mechanism for controlling the balance between self-renewal and neuronal differentiation during the asymmetric division of Drosophila larval NBs. ..
  33. de la Cova C, Johnston L. Myc in model organisms: a view from the flyroom. Semin Cancer Biol. 2006;16:303-12 pubmed
    The Myc transcription factor regulates fundamental processes in a cell's life: its growth, division, and survival...
  34. Moberg K, Mukherjee A, Veraksa A, Artavanis Tsakonas S, Hariharan I. The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol. 2004;14:965-74 pubmed
    ..Drosophila ortholog of a human tumor suppressor, negatively regulates the levels and activity of Drosophila Myc (dMyc) protein in vivo...
  35. Goodliffe J, Cole M, Wieschaus E. Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1. BMC Mol Biol. 2007;8:40 pubmed
    ..chromatin binding proteins with a potential role in controlling Myc activity, we established a genetic assay for dMyc activity in Drosophila...
  36. Li W, Baker N. Engulfment is required for cell competition. Cell. 2007;129:1215-25 pubmed
    ..Wild-type cells can themselves be killed by cells with elevated engulfing activity. Thus engulfment genes act downstream of growth differences between cells to eliminate cells with reduced ribosomal gene dose. ..
  37. Neumüller R, Betschinger J, Fischer A, Bushati N, Poernbacher I, Mechtler K, et al. Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature. 2008;454:241-5 pubmed publisher
    ..Mei-P26 and Brat have a similar domain composition that is also found in other tumour suppressors and might be a defining property of a new family of microRNA regulators that act specifically in stem cell lineages. ..
  38. Herz H, Chen Z, Scherr H, Lackey M, Bolduc C, Bergmann A. vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development. 2006;133:1871-80 pubmed
    ..In summary, the phenotypic analysis of vps25 mutants highlights the importance of receptor downregulation by endosomal protein sorting for appropriate tissue homeostasis, and may serve as a model for human cancer. ..
  39. Bellosta P, Hulf T, Balla Diop S, Usseglio F, Pradel J, Aragnol D, et al. Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Proc Natl Acad Sci U S A. 2005;102:11799-804 pubmed
    The transcription factor dMyc is the sole Drosophila ortholog of the vertebrate c-myc protooncogenes and a central regulator of growth and cell-cycle progression during normal development...
  40. Scott R, Schuldiner O, Neufeld T. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell. 2004;7:167-78 pubmed
    ..Thus, in cells lacking TOR, autophagy plays a protective role that is dominant over its potential role as a growth suppressor. ..
  41. Cranna N, Mitchell N, Hannan R, Quinn L. Hfp, the Drosophila homolog of the mammalian c-myc transcriptional-repressor and tumor suppressor FIR, inhibits dmyc transcription and cell growth. Fly (Austin). 2011;5:129-33 pubmed
    Here we highlight our recent study, which revealed a mechanism critical for tight regulation of Drosophila myc (dmyc) transcription...
  42. Prober D, Edgar B. Ras1 promotes cellular growth in the Drosophila wing. Cell. 2000;100:435-46 pubmed
    ..Ras upregulated the growth driver dMyc, and both Ras and dMyc increased levels of cyclin E posttranscriptionally...
  43. Shcherbata H, Althauser C, Findley S, Ruohola Baker H. The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions. Development. 2004;131:3169-81 pubmed
    ..In contrast, overexpression of the growth controller Myc does not induce premature endocycles but accelerates the kinetics of normal endocycles...
  44. Demontis F, Perrimon N. Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Development. 2009;136:983-93 pubmed publisher
    ..In muscles, InR/Tor signaling, Foxo and dMyc (Diminutive) are key regulators of endoreplication, which is necessary but not sufficient to induce growth...
  45. Rodrigues A, Zoranovic T, Ayala Camargo A, Grewal S, Reyes Robles T, Krasny M, et al. Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis. Development. 2012;139:4051-61 pubmed publisher
    ..In Drosophila, wing cells with increased Myc or with optimum ribosome function become supercompetitors that kill their wild-type neighbors (called losers) up to ..
  46. Parisi F, Riccardo S, Daniel M, Saqcena M, Kundu N, Pession A, et al. Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo. BMC Biol. 2011;9:65 pubmed publisher
    Genetic studies in Drosophila melanogaster reveal an important role for Myc in controlling growth. Similar studies have also shown how components of the insulin and target of rapamycin (TOR) pathways are key regulators of growth...
  47. de la Cova C, Senoo Matsuda N, Ziosi M, Wu D, Bellosta P, Quinzii C, et al. Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability. Cell Metab. 2014;19:470-83 pubmed publisher
    ..Drosophila cells with extra Myc activity acquire "supercompetitor" status upon confrontation with wild-type (WT) cells, prompting the ..
  48. Jorgensen P, Tyers M. How cells coordinate growth and division. Curr Biol. 2004;14:R1014-27 pubmed
    ..Recently, genetic screens in Drosophila and functional genomics approaches in yeast have macheted into the thicket of cell size control. ..
  49. Wu D, Johnston L. Control of wing size and proportions by Drosophila myc. Genetics. 2010;184:199-211 pubmed publisher
    ..Here we examine the role of the growth regulator dMyc in this process during Drosophila wing imaginal disc development...
  50. Mitchell N, Johanson T, Cranna N, Er A, Richardson H, Hannan R, et al. Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner. Development. 2010;137:2875-84 pubmed publisher
    ..here demonstrate that Hfp achieves cell cycle inhibition via an essential role in the repression of Drosophila myc (dmyc) transcription...
  51. Frei C, Galloni M, Hafen E, Edgar B. The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth. EMBO J. 2005;24:623-34 pubmed
    ..Both functions depend on mRpL12 dosage, suggesting that CycD/Cdk4, mRpL12 and Hph function together in a common pathway that controls cell growth via affecting mitochondrial activity. ..
  52. Duman Scheel M, Johnston L, Du W. Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc Natl Acad Sci U S A. 2004;101:3857-62 pubmed
    ..Wg promotes Rbf function by repressing expression of the G(1)-S regulator Drosophila myc (dmyc)...
  53. Cordero J, Stefanatos R, Myant K, Vidal M, Sansom O. Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development. 2012;139:4524-35 pubmed publisher
    ..Our results indicate that the conserved Wnt target Myc and its binding partner Max are required for the initiation and maintenance of intestinal stem cell (ISC) ..
  54. Gallant P, Shiio Y, Cheng P, Parkhurst S, Eisenman R. Myc and Max homologs in Drosophila. Science. 1996;274:1523-7 pubmed
    ..The dMyc protein is likely encoded by the Drosophila gene diminutive (dm), a mutation in which results in small body size and female sterility caused by degeneration of the ovaries...
  55. Moreno E, Rhiner C. Darwin's multicellularity: from neurotrophic theories and cell competition to fitness fingerprints. Curr Opin Cell Biol. 2014;31:16-22 pubmed publisher
  56. Mortimer N, Moberg K. The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system. Dev Biol. 2007;312:560-71 pubmed
  57. Loo L, Secombe J, Little J, Carlos L, Yost C, Cheng P, et al. The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster. Mol Cell Biol. 2005;25:7078-91 pubmed
    ..The identification of Myc and Max homologs in Drosophila melanogaster has demonstrated a critical role for dMyc in cell growth control...
  58. Hennig K, Neufeld T. Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila. Genesis. 2002;34:107-10 pubmed
  59. Edgar B, Orr Weaver T. Endoreplication cell cycles: more for less. Cell. 2001;105:297-306 pubmed
  60. Portela M, Casas Tinto S, Rhiner C, López Gay J, Dominguez O, Soldini D, et al. Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition. Dev Cell. 2010;19:562-73 pubmed publisher
    ..In addition, certain genes such as the Drosophila homolog of human c-myc (dmyc) are able to transform cells into supercompetitors, which eliminate neighboring wild-type cells by apoptosis and ..
  61. Rhiner C, López Gay J, Soldini D, Casas Tinto S, Martín F, Lombardia L, et al. Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Dev Cell. 2010;18:985-98 pubmed publisher
    ..Cell-cell comparison of relative fwe(Lose) and fwe(ubi) levels ultimately determines which cell undergoes apoptosis. This "extracellular code" may constitute an ancient mechanism to terminate competitive conflicts among cells. ..
  62. Pierce S, Yost C, Anderson S, Flynn E, Delrow J, Eisenman R. Drosophila growth and development in the absence of dMyc and dMnt. Dev Biol. 2008;315:303-16 pubmed publisher
    ..In Drosophila the single ortholog of Myc (dMyc), encoded by the dm gene, influences organismal size and the growth of both mitotic and endoreplicating cells...
  63. Orian A, Delrow J, Rosales Nieves A, Abed M, Metzger D, Paroush Z, et al. A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development. Proc Natl Acad Sci U S A. 2007;104:15771-6 pubmed
    ..interaction between the Drosophila Myc oncogene and the Groucho corepressor that regulates a subset of direct dMyc targets...
  64. Betschinger J, Mechtler K, Knoblich J. Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell. 2006;124:1241-53 pubmed
    ..While Prospero regulates cell-cycle gene transcription, Brat acts as a posttranscriptional inhibitor of dMyc. In brat or prospero mutants, both daughter cells grow and behave like neuroblasts leading to the formation of ..
  65. Tamori Y, Bialucha C, Tian A, Kajita M, Huang Y, Norman M, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010;8:e1000422 pubmed publisher
    ..As far as we are aware, this is the first report that cell competition can occur in a mammalian cell culture system. ..
  66. Steiger D, Furrer M, Schwinkendorf D, Gallant P. Max-independent functions of Myc in Drosophila melanogaster. Nat Genet. 2008;40:1084-91 pubmed publisher
    b>Myc proteins are powerful proto-oncoproteins and important promoters of growth and proliferation during normal development...
  67. Montero L, Müller N, Gallant P. Induction of apoptosis by Drosophila Myc. Genesis. 2008;46:104-11 pubmed publisher
    ..Myc to induce cell-autonomous apoptosis has been shown to be evolutionarily conserved in Drosophila Myc (dMyc)...
  68. Pagliarini R, Xu T. A genetic screen in Drosophila for metastatic behavior. Science. 2003;302:1227-31 pubmed
    ..These findings suggest that the oncogenic background of tissues makes a distinct contribution toward metastatic development. ..
  69. Zaffran S, Chartier A, Gallant P, Astier M, Arquier N, Doherty D, et al. A Drosophila RNA helicase gene, pitchoune, is required for cell growth and proliferation and is a potential target of d-Myc. Development. 1998;125:3571-84 pubmed
    ..homologue is a human DEAD-box RNA helicase, MrDb, whose corresponding gene transcription is directly activated by Myc-Max heterodimers (Grandori, C., Mac, J., Siëbelt, F., Ayer, D. E. and Eisenman, R. N. (1996) EMBO J...
  70. Nolo R, Morrison C, Tao C, Zhang X, Halder G. The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr Biol. 2006;16:1895-904 pubmed
    ..Our data indicate that bantam is an essential target of the Hippo signaling pathway to regulate cell proliferation, cell death, and thus tissue size. ..
  71. Tapon N, Ito N, Dickson B, Treisman J, Hariharan I. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell. 2001;105:345-55 pubmed
    ..In postmitotic mutant cells, levels of Cyclin E and Cyclin A are elevated. This correlates with a tendency for these cells to reenter the cell cycle inappropriately as is observed in the human lesions. ..