Gene Symbol: Mvl
Description: Malvolio
Alias: CG3671, DMT1, Dmel\CG3671, NRM2, dNRAMP, mvl, malvolio, /Divalent metal transporter, CG3671-PB, CG3671-PD, CG3671-PE, CG3671-PF, CG3671-PG, CG3671-PH, Mvl-PB, Mvl-PD, Mvl-PE, Mvl-PF, Mvl-PG, Mvl-PH
Species: fruit fly

Top Publications

  1. Lang M, Braun C, Kanost M, Gorman M. Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2012;109:13337-42 pubmed publisher
    ..Given that MCO1 orthologues are present in all insect genomes analyzed to date, this discovery is an important step toward understanding iron metabolism in insects. ..
  2. Techau M, Valdez Taubas J, Popoff J, Francis R, Seaman M, Blackwell J. Evolution of differences in transport function in Slc11a family members. J Biol Chem. 2007;282:35646-56 pubmed
  3. Søvik E, Lamora A, Seehra G, Barron A, Duncan J, Ben Shahar Y. Drosophila divalent metal ion transporter Malvolio is required in dopaminergic neurons for feeding decisions. Genes Brain Behav. 2017;16:506-514 pubmed publisher
    ..b>Malvolio (Mvl), the sole NRAMP family member in insects, plays a role in food choice behaviors in Drosophila and other ..
  4. D Souza J, Cheah P, Gros P, Chia W, Rodrigues V. Functional complementation of the malvolio mutation in the taste pathway of Drosophila melanogaster by the human natural resistance-associated macrophage protein 1 (Nramp-1). J Exp Biol. 1999;202:1909-15 pubmed
    The malvolio (mvl) gene of Drosophila melanogaster encodes a protein with a high degree of homology to natural resistance-associated macrophage proteins (Nramps)...
  5. Maruyama R, GREVENGOED E, Stempniewicz P, Andrew D. Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene Fork head. PLoS ONE. 2011;6:e20901 pubmed publisher
    ..Overall, this study demonstrates an important role for Fkh in determining how an organ preserves its identity throughout development and provides an alternative paradigm for how FoxA proteins function in organogenesis. ..
  6. Cellier M, Prive G, Belouchi A, Kwan T, Rodrigues V, Chia W, et al. Nramp defines a family of membrane proteins. Proc Natl Acad Sci U S A. 1995;92:10089-93 pubmed
    ..These characteristics suggest that the Nramp polypeptides form part of a group of transporters or channels that act on as yet unidentified substrates. ..
  7. Urasaki A, Mito T, Noji S, Ueda R, Kawakami K. Transposition of the vertebrate Tol2 transposable element in Drosophila melanogaster. Gene. 2008;425:64-8 pubmed publisher
  8. Rose P, Hanna S, Spiridigliozzi A, Wannissorn N, Beiting D, Ross S, et al. Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts. Cell Host Microbe. 2011;10:97-104 pubmed publisher
    ..Consequently, flies mutant for dNRAMP were protected from virus infection...
  9. Orgad S, Nelson H, Segal D, Nelson N. Metal ions suppress the abnormal taste behavior of the Drosophila mutant malvolio. J Exp Biol. 1998;201:115-20 pubmed
    A mutation in the malvolio (mvl) gene affects taste behavior in Drosophila melanogaster. The malvolio gene encodes a protein (MVL) that exhibits homology to the mammalian natural resistance-associated macrophage proteins...

More Information


  1. Folwell J, Barton C, Shepherd D. Immunolocalisation of the D. melanogaster Nramp homologue Malvolio to gut and Malpighian tubules provides evidence that Malvolio and Nramp2 are orthologous. J Exp Biol. 2006;209:1988-95 pubmed
    ..The Drosophila melanogaster Nramp-related gene is known as Malvolio. The localisation of Malvolio protein was inferred from the enhancer trap line initially used to isolate Malvolio ..
  2. Southon A, Farlow A, Norgate M, Burke R, Camakaris J. Malvolio is a copper transporter in Drosophila melanogaster. J Exp Biol. 2008;211:709-16 pubmed publisher
    ..We set out to determine whether Malvolio (Mvl), the Drosophila melanogaster orthologue of DMT1, can also transport Cu...
  3. Dimarcq J, Imler J, Lanot R, Ezekowitz R, Hoffmann J, Janeway C, et al. Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression. Insect Biochem Mol Biol. 1997;27:877-86 pubmed
    ..We also report that expression of several regulatory molecules thought to be involved in the immune response is up-regulated by ecdysone in l(2)mbn cells. ..
  4. González Morales N, Mendoza Ortíz M, Blowes L, Missirlis F, Riesgo Escovar J. Ferritin Is Required in Multiple Tissues during Drosophila melanogaster Development. PLoS ONE. 2015;10:e0133499 pubmed publisher
    ..These functions are required in multiple tissues during Drosophila embryonic development. ..
  5. Soriano S, Calap Quintana P, Llorens J, Al Ramahi I, Gutierrez L, Martínez Sebastián M, et al. Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease. PLoS ONE. 2016;11:e0159209 pubmed publisher
    ..Taken together, these results demonstrate that the metal dysregulation in FRDA includes other metals besides iron, therefore providing a new set of potential therapeutic targets. ..
  6. Rodrigues V, Cheah P, Ray K, Chia W. malvolio, the Drosophila homologue of mouse NRAMP-1 (Bcg), is expressed in macrophages and in the nervous system and is required for normal taste behaviour. EMBO J. 1995;14:3007-20 pubmed
    We report the sequence, expression pattern and mutant phenotype of malvolio (mvl), the Drosophila homologue of mammalian natural resistance-associated macrophage proteins (NRAMPs)...
  7. Shen P, Cai H. Drosophila neuropeptide F mediates integration of chemosensory stimulation and conditioning of the nervous system by food. J Neurobiol. 2001;47:16-25 pubmed
    ..Our results strongly suggest that the dNPF neuronal circuit is an integral part of the sensory system that mediates food signaling, providing the neural basis for understanding how invertebrate NPY regulates food response. ..
  8. Bettedi L, Aslam M, Szular J, Mandilaras K, Missirlis F. Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase. J Exp Biol. 2011;214:971-8 pubmed publisher
    Malvolio (Mvl) encodes the sole Drosophila melanogaster homologue of divalent metal transporter-1 (DMT1). The Drosophila transporter has been implicated in iron, manganese and copper cellular import...
  9. Panda D, Rose P, Hanna S, Gold B, Hopkins K, Lyde R, et al. Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry. Cell Rep. 2013;5:1737-48 pubmed publisher
    ..Thus, this study reveals genes and pathways involved in both infection and iron homeostasis that may serve as targets for antiviral therapeutics or for iron-imbalance disorders. ..
  10. Nelson N. Metal ion transporters and homeostasis. EMBO J. 1999;18:4361-71 pubmed
    ..The studies of yeast metal ion transporters helped to unravel the molecular mechanism of macrophage defense against bacterial infection and hereditary diseases. ..
  11. Tang X, Zhou B. Ferritin is the key to dietary iron absorption and tissue iron detoxification in Drosophila melanogaster. FASEB J. 2013;27:288-98 pubmed publisher
    ..Overall, our study demonstrated Drosophila ferritin is essential to two key aspects of iron homeostasis: dietary iron absorption and tissue iron detoxification. ..