Gene Symbol: mute
Description: muscle wasted
Alias: CG15610, CG33455, CG33456, CG34415, Dmel\CG34415, Dmel_CG33455, Dmel_CG33456, Mute, muscle wasted, CG34415-PC, CG34415-PD, mute-PC, mute-PD
Species: fruit fly

Top Publications

  1. Zhong J, Zhang H, Stanyon C, Tromp G, Finley R. A strategy for constructing large protein interaction maps using the yeast two-hybrid system: regulated expression arrays and two-phase mating. Genome Res. 2003;13:2691-9 pubmed
    ..We also present a three-dimensional pooling scheme to further increase the efficiency of large-scale two-hybrid analyses. ..
  2. Matzat L, Dale R, Lei E. Messenger RNA is a functional component of a chromatin insulator complex. EMBO Rep. 2013;14:916-22 pubmed publisher
    ..Together, these data suggest a novel, noncoding mechanism by which certain mRNAs contribute to chromatin insulator function. ..
  3. Yang X, Sabath I, Kunduru L, Van Wijnen A, Marzluff W, Dominski Z. A conserved interaction that is essential for the biogenesis of histone locus bodies. J Biol Chem. 2014;289:33767-82 pubmed publisher also present at the end of Yin Yang 1-associated protein-related protein (YARP) and its Drosophila homologue, Mute, previously shown to localize to HLBs in Drosophila cells...
  4. Mckay D, Klusza S, Penke T, Meers M, Curry K, McDaniel S, et al. Interrogating the function of metazoan histones using engineered gene clusters. Dev Cell. 2015;32:373-86 pubmed publisher
    ..These findings highlight the power of engineering histones to interrogate genome structure and function in animals. ..
  5. Burch B, Godfrey A, Gasdaska P, Salzler H, Duronio R, Marzluff W, et al. Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila. RNA. 2011;17:1132-47 pubmed publisher
    ..Together, these studies demonstrate that direct interaction between dFLASH and dLsm11 is essential for histone pre-mRNA processing in vivo and for proper development and viability in flies. ..
  6. Bulchand S, Menon S, George S, Chia W. Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. J Cell Sci. 2010;123:2697-707 pubmed publisher
    ..Here, we identify and characterise muscle wasted (mute), a novel component of the Drosophila histone locus body (HLB)...
  7. Salzler H, Tatomer D, Malek P, McDaniel S, Orlando A, Marzluff W, et al. A sequence in the Drosophila H3-H4 Promoter triggers histone locus body assembly and biosynthesis of replication-coupled histone mRNAs. Dev Cell. 2013;24:623-34 pubmed publisher
    ..We conclude that HLB assembly occurs through a stepwise process involving stochastic interactions of individual components that localize to a specific sequence in the H3-H4 promoter. ..
  8. Ozawa N, Furuhashi H, Masuko K, Numao E, Makino T, Yano T, et al. Organ identity specification factor WGE localizes to the histone locus body and regulates histone expression to ensure genomic stability in Drosophila. Genes Cells. 2016;21:442-56 pubmed publisher
    ..Genetic analyses showed that wge suppresses position-effect variegation, and that WGE and a HLB component Mute appears to be synergistically involved in heterochromatin formation...
  9. Tatomer D, Rizzardi L, Curry K, Witkowski A, Marzluff W, Duronio R. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Nucleus. 2014;5:613-25 pubmed publisher
    ..This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions. ..