mus312

Summary

Gene Symbol: mus312
Description: mutagen-sensitive 312
Alias: CG8601, Dmel\CG8601, MUS312, mus(3)312, mutagen-sensitive 312, CG8601-PA, CG8601-PD, CG8601-PE, mus312-PA, mus312-PD, mus312-PE
Species: fruit fly

Top Publications

  1. Boyd J, Golino M, Shaw K, Osgood C, Green M. Third-chromosome mutagen-sensitive mutants of Drosophila melanogaster. Genetics. 1981;97:607-23 pubmed
    ..Mutants from four of the complementation groups are associated with moderate to strong meiotic effects in females. Preliminary biochemical analyses have implicated seven of these loci in DNA metabolism. ..
  2. Fekairi S, Scaglione S, Chahwan C, Taylor E, Tissier A, Coulon S, et al. Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell. 2009;138:78-89 pubmed publisher
    ..Here we report the identification of Slx4 orthologs in metazoa, including fly MUS312, essential for meiotic recombination, and human BTBD12, an ATM/ATR checkpoint kinase substrate...
  3. Andersen S, Bergstralh D, Kohl K, Larocque J, Moore C, Sekelsky J. Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination. Mol Cell. 2009;35:128-35 pubmed publisher
    ..Previously, we determined that the Drosophila MEI-9-ERCC1 endonuclease interacts with the MUS312 protein to produce meiotic crossovers, and that MUS312 has a MEI-9-independent role in interstrand crosslink (ICL) ..
  4. Yildiz O, Majumder S, Kramer B, Sekelsky J. Drosophila MUS312 interacts with the nucleotide excision repair endonuclease MEI-9 to generate meiotic crossovers. Mol Cell. 2002;10:1503-9 pubmed
    ..We report here the identification of MUS312, a protein that physically interacts with MEI-9...
  5. Green M. mus(3)312D1, A mutagen sensitive mutant with profound effects on female meiosis in Drosophila melanogaster. Chromosoma. 1981;82:259-66 pubmed
    ..The mutant maps to the left arm of chromosome III between ru and h, and represents a new genetic site for a meiotic mutant. ..
  6. Laurencon A, Orme C, Peters H, Boulton C, Vladar E, Langley S, et al. A large-scale screen for mutagen-sensitive loci in Drosophila. Genetics. 2004;167:217-31 pubmed
    ..At least one allele of each new gene identified in this study is available at the Bloomington Stock Center. ..
  7. Radford S, Goley E, Baxter K, McMahan S, Sekelsky J. Drosophila ERCC1 is required for a subset of MEI-9-dependent meiotic crossovers. Genetics. 2005;170:1737-45 pubmed
    ..We conclude that MEI-9 can generate some meiotic crossovers in an ERCC1-independent manner. ..
  8. Oliveri D, Harris P, Boyd J. X-ray sensitivity and single-strand DNA break repair in mutagen-sensitive mutants of Drosophila melanogaster. Mutat Res. 1990;235:25-31 pubmed
    ..Repair of single-strand breaks is therefore mediated by repair processes unrelated to those that are disrupted in the current mutant collection. ..
  9. Joyce E, McKim K. Drosophila PCH2 is required for a pachytene checkpoint that monitors double-strand-break-independent events leading to meiotic crossover formation. Genetics. 2009;181:39-51 pubmed publisher
    ..Interestingly, PCH2-dependent delays in prophase may allow additional crossovers to form. ..

More Information

Publications19

  1. de Buendía P. Search for DNA repair pathways in Drosophila melanogaster. Mutat Res. 1998;407:67-84 pubmed
    ..A possible explanation could be a weaker control of post-replication repair mechanisms in Drosophila than in yeast. It is expected that this research could help for a better understanding of repair mechanisms in complex organisms. ..
  2. Andersen S, Kuo H, Savukoski D, Brodsky M, Sekelsky J. Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila. PLoS Genet. 2011;7:e1002315 pubmed publisher
    ..Previous studies with Drosophila melanogaster showed that, as in yeast, loss of both DmBLM and MUS81 or MUS312 (the ortholog of SLX4) is lethal. We have now recovered and analyzed mutations in Drosophila Gen...
  3. Chandra S, Pandey A, Chowdhuri D. MiRNA profiling provides insights on adverse effects of Cr(VI) in the midgut tissues of Drosophila melanogaster. J Hazard Mater. 2015;283:558-67 pubmed publisher
    ..DNA damage repair, oxidation-reduction processes, development and differentiation. Down-regulation of mus309 and mus312 under DNA repair, acon to oxidation-reduction and pyd to stress activated MAPK cascade respectively belonging to ..
  4. Heyer W, Ehmsen K, Solinger J. Holliday junctions in the eukaryotic nucleus: resolution in sight?. Trends Biochem Sci. 2003;28:548-57 pubmed
    ..The endonucleases Mus81/Mms4-Eme1 and XPF-MEI-9/MUS312 are structurally related to the archaeal resolvase Hjc and were found to be involved in crossover formation in ..
  5. Wei D, Rong Y. A genetic screen for DNA double-strand break repair mutations in Drosophila. Genetics. 2007;177:63-77 pubmed
  6. Kuo H, McMahan S, Rota C, Kohl K, Sekelsky J. Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases. Genetics. 2014;198:935-45 pubmed publisher
    ..When BLM is absent, three nucleases believed to function as Holliday junction resolvases--MUS81-MMS4, MUS312-SLX1, and GEN--become essential...
  7. Yildiz O, Kearney H, Kramer B, Sekelsky J. Mutational analysis of the Drosophila DNA repair and recombination gene mei-9. Genetics. 2004;167:263-73 pubmed
  8. Edwards A, Mackay T. Quantitative trait loci for aggressive behavior in Drosophila melanogaster. Genetics. 2009;182:889-97 pubmed publisher
    ..Extensive epistasis poses a serious challenge for understanding the genetic basis of complex traits. ..
  9. Olsen O, Green M. The mutagenic effects of diepoxybutane in wild-type and mutagen-sensitive mutants of Drosophila melanogaster. Mutat Res. 1982;92:107-15 pubmed
    ..By inference the same is also the case in females homozygous for 3 other mutagen-sensitive mutants. ..
  10. Bolterstein E, Rivero R, Marquez M, McVey M. The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress. Genetics. 2014;197:643-52 pubmed publisher
    ..We propose that WRNexo and BLM interact to promote fork reversal following replication fork stalling and in their absence regressed forks are restarted through a Rad51-mediated process. ..