Genomes and Genes
Gene Symbol: mus304
Description: mutagen-sensitive 304
Alias: ATRIP, CG7347, Dmel\CG7347, Mus304, anon-WO0140519.82, atrip, mus(3)304, mus-304, mutagen-sensitive 304, ATR-interacting protein, CG7347-PA, mus304-PA, mutagen sensitive 304
Species: fruit fly
- Shim H, Lee E, Nguyen L, Shim J, Song Y. High-dose irradiation induces cell cycle arrest, apoptosis, and developmental defects during Drosophila oogenesis. PLoS ONE. 2014;9:e89009 pubmed publisher..In summary, irradiated germline cells induced DSBs, cell cycle arrest, apoptosis, and developmental defects resulting in reduction of egg production and defective embryogenesis. ..
- Walworth N. Cell-cycle checkpoint kinases: checking in on the cell cycle. Curr Opin Cell Biol. 2000;12:697-704 pubmed..In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways. ..
- Larocque J, Dougherty D, Hussain S, Sekelsky J. Reducing DNA polymerase alpha in the absence of Drosophila ATR leads to P53-dependent apoptosis and developmental defects. Genetics. 2007;176:1441-51 pubmed..In the absence of MEI-41, heterozygosity for the E(mus304) mutation causes rough eyes...
- Radcliffe C, Silva E, Campbell S. A method for assaying the sensitivity of Drosophila replication checkpoint mutants to anti-cancer and DNA-damaging drugs. Genome. 2002;45:881-9 pubmed..The mutants show distinct differences in their sensitivity to each of the drugs tested, suggesting an underlying complexity in the responses of individual checkpoint genes to genotoxic stress. ..
- Morciano P, Carrisi C, Capobianco L, Mannini L, Burgio G, Cestra G, et al. A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity. Hum Mol Genet. 2009;18:4180-8 pubmed publisher..This study therefore provides an intriguing and unexpected link between intermediary metabolism and epigenetic control of genome stability. ..
- Wei D, Rong Y. A genetic screen for DNA double-strand break repair mutations in Drosophila. Genetics. 2007;177:63-77 pubmed
- Cohen S, Yacobi K, Segal D. Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila. Genome Res. 2003;13:1133-45 pubmed..Mutations in the genes okra, mus309, and mei41 did not affect eccDNA under normal conditions or following mutagen treatment, implying that eccDNA formation is different from known pathways of DNA repair. ..
- McKee B, Hong C, Das S. On the roles of heterochromatin and euchromatin in meiosis in drosophila: mapping chromosomal pairing sites and testing candidate mutations for effects on X-Y nondisjunction and meiotic drive in male meiosis. Genetica. 2000;109:77-93 pubmed..No strong effects on disjunction were seen. However, the tests did uncover several mutations that suppress or enhance the meiotic drive (distorted X-Y recovery ratio) that accompanies X-Y pairing failure...
- Raffa G, Cenci G, Ciapponi L, Gatti M. Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres. Front Oncol. 2013;3:112 pubmed publisher..The identification of additional Drosophila genes encoding non-terminin proteins involved in telomere protection might lead to the discovery of novel components of human telomeres. ..
- Boyd J, Harris P. Mutants partially defective in excision repair at five autosomal loci in Drosophila melanogaster. Chromosoma. 1981;82:249-57 pubmed..This study, therefore, brings the total number of Drosophila mutants known to be defective in excision repair to seven. The results are discussed relative to other genetic and biochemical properties of these mutants. ..
- Laurencon A, Orme C, Peters H, Boulton C, Vladar E, Langley S, et al. A large-scale screen for mutagen-sensitive loci in Drosophila. Genetics. 2004;167:217-31 pubmed..At least one allele of each new gene identified in this study is available at the Bloomington Stock Center. ..
- Oliveri D, Harris P, Boyd J. X-ray sensitivity and single-strand DNA break repair in mutagen-sensitive mutants of Drosophila melanogaster. Mutat Res. 1990;235:25-31 pubmed..Repair of single-strand breaks is therefore mediated by repair processes unrelated to those that are disrupted in the current mutant collection. ..
- Vidwans S, Su T. Cycling through development in Drosophila and other metazoa. Nat Cell Biol. 2001;3:E35-9 pubmed..Here we present the various modes of cell-cycle regulation in metazoa and discuss their possible generation by a combination of universally conserved molecules and new regulatory circuits. ..
- de Buendía P. Search for DNA repair pathways in Drosophila melanogaster. Mutat Res. 1998;407:67-84 pubmed..A possible explanation could be a weaker control of post-replication repair mechanisms in Drosophila than in yeast. It is expected that this research could help for a better understanding of repair mechanisms in complex organisms. ..
- Harris P, Boyd J. Re-evaluation of excision repair in the mus304, mus306 and mus308 mutants of Drosophila. Mutat Res. 1993;301:51-5 pubmed..A partial deficiency in the excision repair of pyrimidine dimers originally observed in the mus304 mutants is now attributed to the presence of a secondary phr mutation in that stock...
- Boyd J, Shaw K. Postreplication repair defects in mutants of Drosophila melanogaster. Mol Gen Genet. 1982;186:289-94 pubmed..Two additional defects in postreplication repair were observed with the brain-ganglia assay in strains that cannot be assayed in cell culture [mus(1)108, mus(2)206]. ..
- Boyd J, Sakaguchi K, Harris P. mus308 mutants of Drosophila exhibit hypersensitivity to DNA cross-linking agents and are defective in a deoxyribonuclease. Genetics. 1990;125:813-9 pubmed..The Drosophila mus308 mutants show promise of providing a useful model for analogous defects in other organisms including man. ..