Gene Symbol: mus304
Description: mutagen-sensitive 304
Alias: ATRIP, CG7347, Dmel\CG7347, Mus304, anon-WO0140519.82, atrip, mus(3)304, mus-304, mutagen-sensitive 304, ATR-interacting protein, CG7347-PA, mus304-PA, mutagen sensitive 304
Species: fruit fly

Top Publications

  1. Musarò M, Ciapponi L, Fasulo B, Gatti M, Cenci G. Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint. Nat Genet. 2008;40:362-6 pubmed publisher
    ..The cell cycle arrest elicited by the DDR was alleviated by mutations in mei-41 (encoding ATR), mus304 (ATRIP), grp (Chk1) and rad50 but not by mutations in tefu (ATM)...
  2. Rong Y. Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks. Chromosoma. 2008;117:235-42 pubmed publisher
    ..I review recent progress in Drosophila telomere studies, and challenge the notion that Drosophila may not be a relevant model for the study of telomere maintenance. ..
  3. Lee E, Trinh T, Shim H, Park S, Nguyen T, Kim M, et al. Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks. DNA Repair (Amst). 2012;11:741-52 pubmed publisher
    ..In summary, our data suggest that Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks, and this difference is probably due to distinct phosphorylation statuses. ..
  4. Boyd J, Golino M, Shaw K, Osgood C, Green M. Third-chromosome mutagen-sensitive mutants of Drosophila melanogaster. Genetics. 1981;97:607-23 pubmed
    ..Mutants from four of the complementation groups are associated with moderate to strong meiotic effects in females. Preliminary biochemical analyses have implicated seven of these loci in DNA metabolism. ..
  5. Brodsky M, Sekelsky J, Tsang G, Hawley R, Rubin G. mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development. Genes Dev. 2000;14:666-78 pubmed
    ..We have used this assay to show that the mutagen-sensitive gene mus304 is also required for this checkpoint...
  6. Abdu U, Brodsky M, Schupbach T. Activation of a meiotic checkpoint during Drosophila oogenesis regulates the translation of Gurken through Chk2/Mnk. Curr Biol. 2002;12:1645-51 pubmed
    ..In addition, we found that p53 and mus304, the Drosophila ATR-IP homolog, are not required for the patterning defects caused by the meiotic DNA repair ..
  7. Beaucher M, Zheng X, Amariei F, Rong Y. Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline. Genetics. 2012;191:407-17 pubmed publisher
    ..We showed that disruption of DSB repair factors (Rad51 or DNA ligase IV) or DSB sensing factors (ATRIP or MDC1) resulted in more efficient telomere formation...
  8. Oikemus S, Queiroz Machado J, Lai K, McGinnis N, Sunkel C, Brodsky M. Epigenetic telomere protection by Drosophila DNA damage response pathways. PLoS Genet. 2006;2:e71 pubmed
    ..We examined the roles of the Drosophila atm and atr-atrip DNA damage response pathways and the nbs homolog in DNA damage responses and telomere protection...
  9. Bi X, Srikanta D, Fanti L, Pimpinelli S, Badugu R, Kellum R, et al. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc Natl Acad Sci U S A. 2005;102:15167-72 pubmed

More Information


  1. Shim H, Lee E, Nguyen L, Shim J, Song Y. High-dose irradiation induces cell cycle arrest, apoptosis, and developmental defects during Drosophila oogenesis. PLoS ONE. 2014;9:e89009 pubmed publisher
    ..In summary, irradiated germline cells induced DSBs, cell cycle arrest, apoptosis, and developmental defects resulting in reduction of egg production and defective embryogenesis. ..
  2. Walworth N. Cell-cycle checkpoint kinases: checking in on the cell cycle. Curr Opin Cell Biol. 2000;12:697-704 pubmed
    ..In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways. ..
  3. Larocque J, Dougherty D, Hussain S, Sekelsky J. Reducing DNA polymerase alpha in the absence of Drosophila ATR leads to P53-dependent apoptosis and developmental defects. Genetics. 2007;176:1441-51 pubmed
    ..In the absence of MEI-41, heterozygosity for the E(mus304) mutation causes rough eyes...
  4. Radcliffe C, Silva E, Campbell S. A method for assaying the sensitivity of Drosophila replication checkpoint mutants to anti-cancer and DNA-damaging drugs. Genome. 2002;45:881-9 pubmed
    ..The mutants show distinct differences in their sensitivity to each of the drugs tested, suggesting an underlying complexity in the responses of individual checkpoint genes to genotoxic stress. ..
  5. Wood A, Van Bortle K, Ramos E, Takenaka N, Rohrbaugh M, Jones B, et al. Regulation of chromatin organization and inducible gene expression by a Drosophila insulator. Mol Cell. 2011;44:29-38 pubmed publisher
  6. Morciano P, Carrisi C, Capobianco L, Mannini L, Burgio G, Cestra G, et al. A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity. Hum Mol Genet. 2009;18:4180-8 pubmed publisher
    ..This study therefore provides an intriguing and unexpected link between intermediary metabolism and epigenetic control of genome stability. ..
  7. Wei D, Rong Y. A genetic screen for DNA double-strand break repair mutations in Drosophila. Genetics. 2007;177:63-77 pubmed
  8. Cohen S, Yacobi K, Segal D. Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila. Genome Res. 2003;13:1133-45 pubmed
    ..Mutations in the genes okra, mus309, and mei41 did not affect eccDNA under normal conditions or following mutagen treatment, implying that eccDNA formation is different from known pathways of DNA repair. ..
  9. McKee B, Hong C, Das S. On the roles of heterochromatin and euchromatin in meiosis in drosophila: mapping chromosomal pairing sites and testing candidate mutations for effects on X-Y nondisjunction and meiotic drive in male meiosis. Genetica. 2000;109:77-93 pubmed
    ..No strong effects on disjunction were seen. However, the tests did uncover several mutations that suppress or enhance the meiotic drive (distorted X-Y recovery ratio) that accompanies X-Y pairing failure...
  10. Raffa G, Cenci G, Ciapponi L, Gatti M. Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres. Front Oncol. 2013;3:112 pubmed publisher
    ..The identification of additional Drosophila genes encoding non-terminin proteins involved in telomere protection might lead to the discovery of novel components of human telomeres. ..
  11. Boyd J, Harris P. Mutants partially defective in excision repair at five autosomal loci in Drosophila melanogaster. Chromosoma. 1981;82:249-57 pubmed
    ..This study, therefore, brings the total number of Drosophila mutants known to be defective in excision repair to seven. The results are discussed relative to other genetic and biochemical properties of these mutants. ..
  12. Ryu T, Spatola B, Delabaere L, Bowlin K, Hopp H, Kunitake R, et al. Heterochromatic breaks move to the nuclear periphery to continue recombinational repair. Nat Cell Biol. 2015;17:1401-11 pubmed publisher
  13. Laurencon A, Orme C, Peters H, Boulton C, Vladar E, Langley S, et al. A large-scale screen for mutagen-sensitive loci in Drosophila. Genetics. 2004;167:217-31 pubmed
    ..At least one allele of each new gene identified in this study is available at the Bloomington Stock Center. ..
  14. Oliveri D, Harris P, Boyd J. X-ray sensitivity and single-strand DNA break repair in mutagen-sensitive mutants of Drosophila melanogaster. Mutat Res. 1990;235:25-31 pubmed
    ..Repair of single-strand breaks is therefore mediated by repair processes unrelated to those that are disrupted in the current mutant collection. ..
  15. Vidwans S, Su T. Cycling through development in Drosophila and other metazoa. Nat Cell Biol. 2001;3:E35-9 pubmed
    ..Here we present the various modes of cell-cycle regulation in metazoa and discuss their possible generation by a combination of universally conserved molecules and new regulatory circuits. ..
  16. de Buendía P. Search for DNA repair pathways in Drosophila melanogaster. Mutat Res. 1998;407:67-84 pubmed
    ..A possible explanation could be a weaker control of post-replication repair mechanisms in Drosophila than in yeast. It is expected that this research could help for a better understanding of repair mechanisms in complex organisms. ..
  17. Harris P, Boyd J. Re-evaluation of excision repair in the mus304, mus306 and mus308 mutants of Drosophila. Mutat Res. 1993;301:51-5 pubmed
    ..A partial deficiency in the excision repair of pyrimidine dimers originally observed in the mus304 mutants is now attributed to the presence of a secondary phr mutation in that stock...
  18. Tan K, Goh S, Minakhina S. Genetic screen for regulators of lymph gland homeostasis and hemocyte maturation in Drosophila. G3 (Bethesda). 2012;2:393-405 pubmed publisher
  19. Boyd J, Shaw K. Postreplication repair defects in mutants of Drosophila melanogaster. Mol Gen Genet. 1982;186:289-94 pubmed
    ..Two additional defects in postreplication repair were observed with the brain-ganglia assay in strains that cannot be assayed in cell culture [mus(1)108, mus(2)206]. ..
  20. Boyd J, Sakaguchi K, Harris P. mus308 mutants of Drosophila exhibit hypersensitivity to DNA cross-linking agents and are defective in a deoxyribonuclease. Genetics. 1990;125:813-9 pubmed
    ..The Drosophila mus308 mutants show promise of providing a useful model for analogous defects in other organisms including man. ..