MtnD

Summary

Gene Symbol: MtnD
Description: Metallothionein D
Alias: CG33192, Dmel\CG33192, mtnD, metallothionein D, CG33192-PB, MtnD-PB, metallothionein
Species: fruit fly

Top Publications

  1. Southon A, Burke R, Norgate M, Batterham P, Camakaris J. Copper homoeostasis in Drosophila melanogaster S2 cells. Biochem J. 2004;383:303-9 pubmed
    ..and SCO1 and SCO2, did not significantly respond transcriptionally to increased Cu levels, whereas MtnA, MtnB and MtnD (Drosophila orthologues of human metallothioneins) were up-regulated by Cu in a time- and dose-dependent manner...
  2. Egli D, Yepiskoposyan H, Selvaraj A, Balamurugan K, Rajaram R, Simons A, et al. A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. Mol Cell Biol. 2006;26:2286-96 pubmed
    ..Here, we report the generation of a metallothionein gene family knockout in Drosophila melanogaster by targeted disruption of all four genes (MtnA to -D)...
  3. Wang X, Wu Y, Zhou B. Dietary zinc absorption is mediated by ZnT1 in Drosophila melanogaster. FASEB J. 2009;23:2650-61 pubmed publisher
    ..This study will be helpful in understanding the fundamental process of acquiring dietary zinc in higher eukaryotes. ..
  4. Guirola M, Naranjo Y, Capdevila M, Atrian S. Comparative genomics analysis of metallothioneins in twelve Drosophila species. J Inorg Biochem. 2011;105:1050-9 pubmed publisher
    ..melanogaster, where four isogenes (MtnA to MtnD) are known and deeply characterized. We include a fifth isoform in this study, named MtnE, and recently annotated...
  5. Atanesyan L, Günther V, Celniker S, Georgiev O, Schaffner W. Characterization of MtnE, the fifth metallothionein member in Drosophila. J Biol Inorg Chem. 2011;16:1047-56 pubmed publisher
    ..Here we characterize a new fifth member of Drosophila MT gene family, coding for metallothionein E (MtnE). The MtnE transcription unit is located head-to-head with the one of MtnD...
  6. Egli D, Selvaraj A, Yepiskoposyan H, Zhang B, Hafen E, Georgiev O, et al. Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. EMBO J. 2003;22:100-8 pubmed
    ..In the mouse, it activates metallothionein genes and other target genes in response to several cell stress conditions, notably heavy metal load...
  7. Egli D, Domènech J, Selvaraj A, Balamurugan K, Hua H, Capdevila M, et al. The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification. Genes Cells. 2006;11:647-58 pubmed
    Four metallothionein genes are present in the Drosophila melanogaster genome, designated MtnA, MtnB, MtnC, MtnD, all of which are transcriptionally induced by heavy metals through the same metal-responsive transcription factor, MTF-1...
  8. Balamurugan K, Egli D, Hua H, Rajaram R, Seisenbacher G, Georgiev O, et al. Copper homeostasis in Drosophila by complex interplay of import, storage and behavioral avoidance. EMBO J. 2007;26:1035-44 pubmed
    ..it induces the Ctr1B copper importer gene, whereas at high copper concentrations, it mainly induces the metallothionein genes...
  9. Chamilos G, Lewis R, Hu J, Xiao L, Zal T, Gilliet M, et al. Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Natl Acad Sci U S A. 2008;105:9367-72 pubmed publisher
    ..Our results provide insights into the factors that mediate host-pathogen interactions in zygomycosis and establish D. melanogaster as a promising model to study this important mycosis...

More Information

Publications12

  1. Kappeler M, Kranz E, Woolcock K, Georgiev O, Schaffner W. Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences. Nucleic Acids Res. 2008;36:6907-17 pubmed publisher
    ..Unexpectedly, distinct from its function in Saccharomyces cerevisiae, the mismatch repair factor Msh2 encoded by spel1 does not suppress homeologous SSA in Drosophila. ..
  2. Günther V, Waldvogel D, Nosswitz M, Georgiev O, Schaffner W. Dissection of Drosophila MTF-1 reveals a domain for differential target gene activation upon copper overload vs. copper starvation. Int J Biochem Cell Biol. 2012;44:404-11 pubmed publisher
    ..It mediates protection against heavy metal load by activating the expression of metallothionein and other genes...
  3. Pérez Rafael S, Kurz A, Guirola M, Capdevila M, Palacios O, Atrian S. Is MtnE, the fifth Drosophila metallothionein, functionally distinct from the other members of this polymorphic protein family?. Metallomics. 2012;4:342-9 pubmed publisher
    ..Until recently, the Drosophila MT system was assumed to be composed of 4 isoforms (MtnA, MtnB, MtnC and MtnD), all of them responsive to heavy metal load through the dMTF1 transcription factor...