mr

Summary

Gene Symbol: mr
Description: morula
Alias: APC2, APC2/mr, Apc2, CG3060, Dmel\CG3060, dAPC2, morula, CG3060-PA, mr-PA
Species: fruit fly

Top Publications

  1. Kashevsky H, Wallace J, Reed B, Lai C, Hayashi Hagihara A, Orr Weaver T. The anaphase promoting complex/cyclosome is required during development for modified cell cycles. Proc Natl Acad Sci U S A. 2002;99:11217-22 pubmed
    ..The Drosophila morula (mr) gene regulates variant cell cycles, because in addition to disrupting the archetypal cycle (G1-S-G2-M), mr ..
  2. van Roessel P, Elliott D, Robinson I, Prokop A, Brand A. Independent regulation of synaptic size and activity by the anaphase-promoting complex. Cell. 2004;119:707-18 pubmed
    ..In neurons, the APC/C controls synaptic size via a downstream effector Liprin-alpha; in muscles, the APC/C regulates synaptic transmission, controlling the concentration of a postsynaptic glutamate receptor. ..
  3. Zielke N, Querings S, Rottig C, Lehner C, Sprenger F. The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles. Genes Dev. 2008;22:1690-703 pubmed publisher
    ..Geminin is only abundant in cells with high CycE-Cdk2 activity, suggesting that APC/C-Fzr activity is periodically inhibited by CycE-Cdk2, to prevent relicensing in S-phase cells. ..
  4. Pesin J, Orr Weaver T. Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator. PLoS Genet. 2007;3:e202 pubmed
    ..Our studies reveal the mechanism for developmental regulation of an APC/C activator and suggest it is one strategy for control of the female meiotic cell cycle in a multicellular organism. ..
  5. Reed B, Orr Weaver T. The Drosophila gene morula inhibits mitotic functions in the endo cell cycle and the mitotic cell cycle. Development. 1997;124:3543-53 pubmed
    ..We show that the Drosophila morula gene is essential to maintain the absence of mitosis during the endo cycle...
  6. Baxley R, Soshnev A, Koryakov D, Zhimulev I, Geyer P. The role of the Suppressor of Hairy-wing insulator protein in Drosophila oogenesis. Dev Biol. 2011;356:398-410 pubmed publisher
    ..2 and CP190, these proteins are not essential for oogenesis. These studies represent the first molecular investigations of Su(Hw) function in the germline, which uncover distinct requirements for Su(Hw) insulator and ovary functions. ..
  7. Sugimura I, Lilly M. Bruno inhibits the expression of mitotic cyclins during the prophase I meiotic arrest of Drosophila oocytes. Dev Cell. 2006;10:127-35 pubmed
  8. Chen D, Wang Q, Huang H, Xia L, Jiang X, Kan L, et al. Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila. Development. 2009;136:4133-42 pubmed publisher
    ..We show that Eff both physically and genetically interacts with dAPC2, a key component of the anaphase-promoting complex (APC), which acts as a multisubunit E3 ligase and plays an ..
  9. Whitfield Z, Chisholm J, Hawley R, Orr Weaver T. A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony. PLoS Biol. 2013;11:e1001648 pubmed publisher
    ..These data indicate APC(Cort) ubiquitylates Mtrm at the oocyte-to-embryo transition, thus preventing excessive inhibition of Polo kinase activity due to Mtrm's presence. ..

More Information

Publications25

  1. Royzman I, Orr Weaver T. S phase and differential DNA replication during Drosophila oogenesis. Genes Cells. 1998;3:767-76 pubmed
    ..Cyclin E and E2F are needed for this differential DNA replication during Drosophila oogenesis. ..
  2. Lasko P, Ashburner M. Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development. Genes Dev. 1990;4:905-21 pubmed
    ..These results are discussed with respect to the multiple functions of the vasa gene. ..
  3. Silies M, Klämbt C. APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS. Nat Neurosci. 2010;13:1357-64 pubmed publisher
    ..This represents a simple mechanism by which a subcellular gradient of adhesiveness can coordinate glial migration with axonal growth...
  4. Buttitta L, Katzaroff A, Edgar B. A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. J Cell Biol. 2010;189:981-96 pubmed publisher
    ..These mechanisms are essential for proper development, as evading them leads to tissue outgrowths composed of dividing but terminally differentiated cells. ..
  5. Narbonne Reveau K, Senger S, Pal M, Herr A, Richardson H, Asano M, et al. APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle. Development. 2008;135:1451-61 pubmed publisher
  6. Gridley T, Gray D, Orr Weaver T, Soriano P, Barton D, Francke U, et al. Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila. Development. 1990;109:235-42 pubmed
    ..In situ hybridization to Drosophila polytene chromosomes localizes the Drosophila homolog to 60B,C on chromosome 2. Several Drosophila lethal mutations also map to this region. ..
  7. Slack C, Overton P, Tuxworth R, Chia W. Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase-promoting complex/cyclosome. Development. 2007;134:3781-7 pubmed
    ..Our results demonstrate that APC/C activity and ubiquitylation of Miranda are required for the asymmetric localisation of Miranda and its cargo proteins to the NB cortex. ..
  8. Vardy L, Pesin J, Orr Weaver T. Regulation of Cyclin A protein in meiosis and early embryogenesis. Proc Natl Acad Sci U S A. 2009;106:1838-43 pubmed publisher
    ..These studies reveal multiple levels of posttranscriptional regulation of Cyclin A protein by translational and proteolytic control during oocyte maturation and the onset of embryogenesis. ..
  9. Acquaviva C, Pines J. The anaphase-promoting complex/cyclosome: APC/C. J Cell Sci. 2006;119:2401-4 pubmed
  10. Mohd Sarip A, Lagarou A, Doyen C, van der Knaap J, Aslan U, Bezstarosti K, et al. Transcription-independent function of Polycomb group protein PSC in cell cycle control. Science. 2012;336:744-7 pubmed publisher
    ..Thus, PSC appears to mediate both developmental gene silencing and posttranslational control of mitosis. Direct regulation of cell cycle progression might be a crucial part of the PcG system's function in development and cancer. ..
  11. Lewis E. The Relation of Repeats to Position Effect in Drosophila Melanogaster. Genetics. 1945;30:137-66 pubmed
  12. Harper J, Burton J, Solomon M. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 2002;16:2179-206 pubmed
  13. Edgar B, Orr Weaver T. Endoreplication cell cycles: more for less. Cell. 2001;105:297-306 pubmed
  14. Hainline S, Rickmyre J, Neitzel L, Lee L, Lee E. The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex. Biol Open. 2014;3:669-76 pubmed publisher
    ..dMCPH1 levels are increased in Drosophila morula (APC2) mutant embryos, consistent with dMCPH1 being an APC substrate in vivo...
  15. Meghini F, Martins T, Tait X, Fujimitsu K, Yamano H, Glover D, et al. Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit. Nat Commun. 2016;7:12607 pubmed publisher
    ..Finally, we show that Spd2 is also a novel APC/C(Fzr) substrate. Our study is the first to demonstrate the critical importance of distinct subcellular pools of APC/C activators in the spatiotemporal control of APC/C activity. ..
  16. Nagy O, Pal M, Udvardy A, Shirras C, Boros I, Shirras A, et al. lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2. Cell Div. 2012;7:9 pubmed publisher
    ..The LmgA protein interacts with Mr/Apc2, and they together form a binding site for Vihar, the E2-C type ubiquitin conjugating enzyme...