Gene Symbol: Mondo
Description: mondo
Alias: 154826_at, CG18362, ChREBP, Dmel\CG18362, Mio, anon-39Da, bHLHd12, dmondo, mio, mlx, mondo, mondo, CG18362-PA, CG18362-PB, CG18362-PE, CG18362-PF, CG18362-PG, CG18362-PH, CG18362-PI, CG18362-PJ, CG18362-PK, CG18362-PL, CG18362-PM, Mlx interactor, Mondo-PA, Mondo-PB, Mondo-PE, Mondo-PF, Mondo-PG, Mondo-PH, Mondo-PI, Mondo-PJ, Mondo-PK, Mondo-PL, Mondo-PM, WBSCR14-related
Species: fruit fly

Top Publications

  1. Billin A, Eilers A, Coulter K, Logan J, Ayer D. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. Mol Cell Biol. 2000;20:8845-54 pubmed
    ..of a new family of basic helix-loop-helix-leucine zipper heterodimeric partners for Mlx termed the Mondo family. MondoA forms homodimers weakly and does not interact with Max or members of the Myc or Mad families...
  2. Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A. WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network. Hum Mol Genet. 2001;10:617-27 pubmed
    ..WBSCR14 forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence CACGTG...
  3. Peyrefitte S, Kahn D, Haenlin M. New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes. Mech Dev. 2001;104:99-104 pubmed
    ..for closely structurally related motifs, we found two genes that represent likely orthologues of vertebrate Mnt and Mlx. Together with previous reports, our data suggest that, similar to networks involved in neurogenesis and myogenesis,..
  4. Docherty J, Manno J, McDermott J, DiAngelo J. Mio acts in the Drosophila brain to control nutrient storage and feeding. Gene. 2015;568:190-5 pubmed publisher
    ..b>Mlx interactor (Mio), the Drosophila homolog of carbohydrate response element binding protein (ChREBP), functions as a ..
  5. Mattila J, Havula E, Suominen E, Teesalu M, Surakka I, Hynynen R, et al. Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Cell Rep. 2015;13:350-64 pubmed publisher
    The ChREBP/Mondo-Mlx transcription factors are activated by sugars and are essential for sugar tolerance. They promote the conversion of sugars to lipids, but beyond this, their physiological roles are insufficiently understood...
  6. Hewes R, Park D, Gauthier S, Schaefer A, Taghert P. The bHLH protein Dimmed controls neuroendocrine cell differentiation in Drosophila. Development. 2003;130:1771-81 pubmed
    ..We propose that dimmed encodes an integral component of a novel mechanism by which diverse neuroendocrine lineages differentiate and maintain the pro-secretory state. ..
  7. Kim S, Shi H, Lee D, Lis J. Specific SR protein-dependent splicing substrates identified through genomic SELEX. Nucleic Acids Res. 2003;31:1955-61 pubmed
    ..These results indicate that B52 has unique functions in the removal of some introns during development, and plays a critical role in cellular regulatory networks. ..
  8. McFerrin L, Atchley W. A novel N-terminal domain may dictate the glucose response of Mondo proteins. PLoS ONE. 2012;7:e34803 pubmed publisher
    ..g. type II diabetes. In vertebrates, the transcription factor ChREBP is a major component in glucose metabolism, while its ortholog MondoA is involved in glucose uptake...
  9. Sassu E, McDermott J, Keys B, Esmaeili M, Keene A, Birnbaum M, et al. Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. Biochem Biophys Res Commun. 2012;426:43-8 pubmed publisher
    ..In this study, we characterized the role of the Drosophila homolog of ChREBP, Mlx interactor (Mio), in controlling fat accumulation in larvae and adult flies...

More Information


  1. Musselman L, Fink J, Ramachandran P, Patterson B, Okunade A, Maier E, et al. Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. J Biol Chem. 2013;288:8028-42 pubmed publisher
    ..Our work supports a critical role for the fat body and the Drosophila carbohydrate response element-binding protein ortholog in metabolic homeostasis in Drosophila...
  2. Havula E, Teesalu M, Hyötyläinen T, Seppälä H, Hasygar K, Auvinen P, et al. Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila. PLoS Genet. 2013;9:e1003438 pubmed publisher
    ..Paralogous Mondo transcription factors ChREBP and MondoA, with their common binding partner Mlx, are key sensors of intracellular glucose flux in mammals...
  3. Matsuda H, Yamada T, Yoshida M, Nishimura T. Flies without trehalose. J Biol Chem. 2015;290:1244-55 pubmed publisher
    ..These diet-dependent phenotypes of Tps1 mutants demonstrate the critical role of trehalose during development in Drosophila and reveal how animals adapt to changes in nutrient availability. ..
  4. Kim G, Lee Y, Lee G, Cho Y, Lee Y, Jang Y, et al. Overexpression of malic enzyme in the larval stage extends Drosophila lifespan. Biochem Biophys Res Commun. 2015;456:676-82 pubmed publisher
    ..Our results suggest that metabolic changes mediated by Men during development might be related to the control of ROS tolerance and the longevity of Drosophila. ..
  5. Polak G, Pasqualino A, Docherty J, Beck S, DiAngelo J. The Regulation of Muscle Structure and Metabolism by Mio/dChREBP in Drosophila. PLoS ONE. 2015;10:e0136504 pubmed publisher
    ..Mio, the Drosophila homolog of carbohydrate response element binding protein (ChREBP), has recently been identified as a nutrient responsive transcription factor important for triglyceride storage in ..
  6. Abramov Y, Shatskikh A, Maksimenko O, Bonaccorsi S, Gvozdev V, Lavrov S. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila. Genetics. 2016;202:93-106 pubmed publisher
    ..We demonstrate that trans-inactivation is followed by de novo HP1a accumulation in the affected transgene; trans-inactivation is specifically favored by the chromatin remodeler SAYP and prevented by Argonaute AGO2. ..