molting defective


Gene Symbol: molting defective
Description: molting defective
Alias: CG13620, CG31312, CG33343, CG34100, CG9469, DTS-3, Dmel\CG34100, L(3)3[DTS], Mld, l(3)3[DTS], l(3)DTS3, molting defective, CG34100-PA, CG34100-PC, CG34100-PD, CG34100-PE, CG34100-PF, defective, dominant temperature-sensitive 3, lethal (3) DTS3, mld-PA, mld-PC, mld-PD, mld-PE, mld-PF, molting
Species: fruit fly

Top Publications

  1. Ono H, Rewitz K, Shinoda T, Itoyama K, Petryk A, Rybczynski R, et al. Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera. Dev Biol. 2006;298:555-70 pubmed
    ..In addition, spok expression is eliminated in larvae carrying mutations in molting defective (mld), a gene encoding a nuclear zinc finger protein that is required for production of ecdysone during ..
  2. Xiang Y, Liu Z, Huang X. br regulates the expression of the ecdysone biosynthesis gene npc1. Dev Biol. 2010;344:800-8 pubmed publisher
    ..These results imply that ecdysone could potentially act through its early response gene br to achieve positive feedback regulation of ecdysone biosynthesis during development. ..
  3. Hackney J, Zolali Meybodi O, Cherbas P. Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila. PLoS ONE. 2012;7:e49105 pubmed publisher
    ..Finally, we show that developmental delays induced by tissue damage are associated with decreased expression of genes involved in ecdysteroid synthesis and signaling. ..
  4. Simon A, Shih C, Mack A, Benzer S. Steroid control of longevity in Drosophila melanogaster. Science. 2003;299:1407-10 pubmed
    ..These observations demonstrate the importance of the ecdysone hormonal pathway, a new player in regulating longevity. ..
  5. Ishimoto H, Sakai T, Kitamoto T. Ecdysone signaling regulates the formation of long-term courtship memory in adult Drosophila melanogaster. Proc Natl Acad Sci U S A. 2009;106:6381-6 pubmed publisher
    ..We also found that mutants in which ecdysone signaling is reduced were defective in LTM, and that an elevation of 20E levels was associated with activation of the cAMP response element binding ..
  6. Ishimoto H, Kitamoto T. The steroid molting hormone Ecdysone regulates sleep in adult Drosophila melanogaster. Genetics. 2010;185:269-81 pubmed publisher
    ..Finally, endogenous ecdysone levels increased after sleep deprivation, and mutants defective for ecdysone signaling displayed little sleep rebound, suggesting that ecdysone is involved in homeostatic sleep ..
  7. Awad T, Truman J. Postembryonic development of the midline glia in the CNS of Drosophila: proliferation, programmed cell death, and endocrine regulation. Dev Biol. 1997;187:283-97 pubmed
    ..The midline glial may play a role during CNS metamorphosis similar to that of their progenitors in the embryo, in stabilizing outgrowing neurites that cross or run along the midline. ..
  8. Neubueser D, Warren J, Gilbert L, Cohen S. molting defective is required for ecdysone biosynthesis. Dev Biol. 2005;280:362-72 pubmed
    ..Here, we report identification of one such gene, which we call molting defective, on the basis of its lethal phenotype...
  9. Holden J, Suzuki D. Temperature-sensitive mutations in Drosophila melanogaster. XII. The genetic and developmental effects of dominant lethals on chromosome 3. Genetics. 1973;73:445-58 pubmed
    ..Only DTS-4 exhibited dominant lethality in triploid females. ..

More Information


  1. Danielsen E, Moeller M, Dorry E, Komura Kawa T, Fujimoto Y, Troelsen J, et al. Transcriptional control of steroid biosynthesis genes in the Drosophila prothoracic gland by ventral veins lacking and knirps. PLoS Genet. 2014;10:e1004343 pubmed publisher
    ..We also show that the transcriptional regulator, Molting defective (Mld), controls early biosynthetic pathway steps...
  2. Lanet E, Gould A, Maurange C. Protection of neuronal diversity at the expense of neuronal numbers during nutrient restriction in the Drosophila visual system. Cell Rep. 2013;3:587-94 pubmed publisher
    ..These studies reveal an adaptive mechanism that helps to retain a functional visual system over a range of different brain sizes in the face of suboptimal nutrition. ..
  3. Segal D. Prospects of using Drosophila for insect neuroendocrine research. Arch Insect Biochem Physiol. 1993;22:199-231 pubmed
    ..Such information should be helpful in designing novel means for pest control based on the specific intervention with endocrine systems regulating insect development and reproduction. ..
  4. Komura Kawa T, Hirota K, Shimada Niwa Y, Yamauchi R, Shimell M, Shinoda T, et al. The Drosophila Zinc Finger Transcription Factor Ouija Board Controls Ecdysteroid Biosynthesis through Specific Regulation of spookier. PLoS Genet. 2015;11:e1005712 pubmed publisher
    ..In insects, the principal steroid hormones are ecdysteroids, which play essential roles in regulating molting and metamorphosis...
  5. Pahi Z, Kiss Z, Komonyi O, Borsos B, Tora L, Boros I, et al. dTAF10- and dTAF10b-Containing Complexes Are Required for Ecdysone-Driven Larval-Pupal Morphogenesis in Drosophila melanogaster. PLoS ONE. 2015;10:e0142226 pubmed publisher
    ..We propose that distinct forms of dTFIID and/or dSAGA exist during Drosophila metamorphosis, wherein different TAF compositions serve to target RNAPII at different developmental stages and tissues. ..
  6. Ishimoto H, Wang Z, Rao Y, Wu C, Kitamoto T. A novel role for ecdysone in Drosophila conditioned behavior: linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain. PLoS Genet. 2013;9:e1003843 pubmed publisher
    ..This study provides novel insights into non-genomic actions of steroids, and opens a new avenue for genetic investigation into an underappreciated mechanism critical to behavioral control by steroids. ..
  7. Ishimoto H, Lark A, Kitamoto T. Factors that Differentially Affect Daytime and Nighttime Sleep in Drosophila melanogaster. Front Neurol. 2012;3:24 pubmed publisher
  8. Talamillo A, Sánchez J, Cantera R, Pérez C, Martin D, Caminero E, et al. Smt3 is required for Drosophila melanogaster metamorphosis. Development. 2008;135:1659-68 pubmed publisher
    ..In summary, our study indicates that Smt3 is required for the ecdysteroid synthesis pathway at the time of puparium formation. ..
  9. Kozlova T, Thummel C. Steroid regulation of postembryonic development and reproduction in Drosophila. Trends Endocrinol Metab. 2000;11:276-80 pubmed
    ..The ecdysteroid hierarchy was also shown recently to regulate Drosophila oogenesis and reproduction. ..
  10. PETRUCCELLI E, Li Q, Rao Y, Kitamoto T. The Unique Dopamine/Ecdysteroid Receptor Modulates Ethanol-Induced Sedation in Drosophila. J Neurosci. 2016;36:4647-57 pubmed publisher
    ..Our work provides a foundation for further characterizing the function and mechanisms of action of nonclassical steroid GPCR signaling. ..