Gene Symbol: mmy
Description: mummy
Alias: BcDNA:LD24639, CG9535, Dmel\CG9535, LD44264, anon-WO0140519.242, cao, cys, cyst, cystic, l(2)k13717b, mum, mummy, CG9535-PA, CG9535-PB, CG9535-PD, UDP-GlcNAc pyrophosphorylase, cabrio, cystic, mmy-PA, mmy-PB, mmy-PD
Species: fruit fly

Top Publications

  1. Araújo S, Aslam H, Tear G, Casanova J. mummy/cystic encodes an enzyme required for chitin and glycan synthesis, involved in trachea, embryonic cuticle and CNS development--analysis of its role in Drosophila tracheal morphogenesis. Dev Biol. 2005;288:179-93 pubmed
    ..Here, we show that these alleles, and the previously identified cystic and mummy, all belong to the same complementation group...
  2. Behr M, Riedel D, Schuh R. The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila. Dev Cell. 2003;5:611-20 pubmed
    ..The results indicate that claudin-like proteins are functionally conserved between vertebrates and Drosophila. ..
  3. Paul S, Ternet M, Salvaterra P, Beitel G. The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system. Development. 2003;130:4963-74 pubmed
  4. Wu V, Schulte J, Hirschi A, Tepass U, Beitel G. Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. J Cell Biol. 2004;164:313-23 pubmed
    ..same pathway as the septate junction genes neurexin and scribble, but that nervana 2, convoluted, varicose, and cystic have functions not shared by sinuous...
  5. Swanson L, Beitel G. Tubulogenesis: an inside job. Curr Biol. 2006;16:R51-3 pubmed
  6. Hummel T, Schimmelpfeng K, Klämbt C. Commissure formation in the embryonic CNS of Drosophila. Development. 1999;126:771-9 pubmed
    ..The results lead to a detailed model relating different cellular functions to axonal patterning at the midline. ..
  7. Rodriguez A, Zhou Z, Tang M, Meller S, Chen J, Bellen H, et al. Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. Genetics. 1996;143:929-40 pubmed
    ..All are associated with reporter gene expression in at least one immune system tissue. Thor has increased expression upon infection. Mutations of wizard and dappled have a melanotic tumor phenotype. ..
  8. Wu V, Beitel G. A junctional problem of apical proportions: epithelial tube-size control by septate junctions in the Drosophila tracheal system. Curr Opin Cell Biol. 2004;16:493-9 pubmed
    ..Possible tube-size functions of septate junctions include patterning of the apical extracellular matrix and regulation of conserved cell polarity genes such as Scribble and Discs Large. ..
  9. Mariappa D, Sauert K, Mariño K, Turnock D, Webster R, van Aalten D, et al. Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila. Sci Signal. 2011;4:ra89 pubmed publisher

More Information


  1. Schimmelpfeng K, Strunk M, Stork T, Klämbt C. Mummy encodes an UDP-N-acetylglucosamine-dipohosphorylase and is required during Drosophila dorsal closure and nervous system development. Mech Dev. 2006;123:487-99 pubmed
    ..Here, we describe the analysis of the cabrio/mummy gene, which encodes an UDP-N-acetylglucosamine diphosphorylase...
  2. Manavalan M, Jayasinghe V, Grewal R, Bhat K. The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons. Sci Signal. 2017;10: pubmed publisher
    ..We showed that the enzyme Mummy (Mmy) controlled Slit-Robo signaling through mechanisms that affected both the ligand and the receptor...
  3. Gangishetti U, Breitenbach S, Zander M, Saheb S, Muller U, Schwarz H, et al. Effects of benzoylphenylurea on chitin synthesis and orientation in the cuticle of the Drosophila larva. Eur J Cell Biol. 2009;88:167-80 pubmed publisher
  4. Tonning A, Helms S, Schwarz H, Uv A, Moussian B. Hormonal regulation of mummy is needed for apical extracellular matrix formation and epithelial morphogenesis in Drosophila. Development. 2006;133:331-41 pubmed
    ..Here, we show that Drosophila mummy (mmy) mutants display defects in epithelial organisation in conjunction with aberrant deposition of the cuticle ..
  5. Devine W, Lubarsky B, Shaw K, Luschnig S, Messina L, Krasnow M. Requirement for chitin biosynthesis in epithelial tube morphogenesis. Proc Natl Acad Sci U S A. 2005;102:17014-9 pubmed
    ..These findings show that chitin regulates epithelial tube morphogenesis, in addition to its classical role protecting mature epithelia. ..
  6. Chavez V, Marques G, Delbecque J, Kobayashi K, Hollingsworth M, Burr J, et al. The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels. Development. 2000;127:4115-26 pubmed
  7. Araújo S, Cela C, Llimargas M. Tramtrack regulates different morphogenetic events during Drosophila tracheal development. Development. 2007;134:3665-76 pubmed
    ..In summary, the involvement of Ttk in different steps of tube morphogenesis identifies it as a key player in tracheal development. ..
  8. Shaik K, Pabst M, Schwarz H, Altmann F, Moussian B. The Alg5 ortholog Wollknäuel is essential for correct epidermal differentiation during Drosophila late embryogenesis. Glycobiology. 2011;21:743-56 pubmed publisher
  9. Humphreys G, Jud M, Monroe K, Kimball S, Higley M, Shipley D, et al. Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila. Dev Biol. 2013;381:434-45 pubmed publisher
    ..Here we show that the mummy (mmy) gene product, which is required for dorsal closure, functions as a BMP signaling antagonist...