Gene Symbol: Mlp60A
Description: Muscle LIM protein at 60A
Alias: BcDNA:RE14544, BcDNA:RH74176, CG30174, CG30179, CG3220, CG33149, CG42309, DLim-2, DMLP1, DMlp1, DmLIM-2, Dmel\CG42309, Dmel_CG30174, Dmel_CG30179, Dmel_CG33149, FBgn0259209, MLIM 60A, MLP, MLP1, Mlp1, Mlp60, dMlp60A, muscle LIM protein at 60A, CG42309-PB, CG42309-PC, CG42309-PE, CG42309-PF, Mlp60A-PB, Mlp60A-PC, Mlp60A-PE, Mlp60A-PF, Muscle-specific LIM protein at 60A, muscle LIM protein 60A
Species: fruit fly

Top Publications

  1. Clark K, McGrail M, Beckerle M. Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes. Development. 2003;130:2611-21 pubmed
    ..Our results provide direct genetic evidence that PINCH is essential for Drosophila development and is required for integrin-dependent cell adhesion. ..
  2. Arber S, Halder G, Caroni P. Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Cell. 1994;79:221-31 pubmed
    ..Its expression and that of its Drosophila homolog DMLP1 are enriched in striated muscle and coincide with myogenic differentiation...
  3. Firdaus H, Mohan J, Naz S, Arathi P, Ramesh S, Nongthomba U. A cis-regulatory mutation in troponin-I of Drosophila reveals the importance of proper stoichiometry of structural proteins during muscle assembly. Genetics. 2015;200:149-65 pubmed publisher
  4. Tikhonov M, Georgiev P, Maksimenko O. Competition within Introns: Splicing Wins over Polyadenylation via a General Mechanism. Acta Naturae. 2013;5:52-61 pubmed
    ..These results confirm that the transcription apparatus ignores premature polyadenylation signals for as long as they are intronic. ..
  5. Toret C, D Ambrosio M, Vale R, Simon M, Nelson W. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. J Cell Biol. 2014;204:265-79 pubmed publisher
    ..These experiments reveal roles for a diversity of cellular pathways that are required for cadherin function in Metazoa, including cytoskeleton organization, cell-substrate interactions, and nuclear and cytoplasmic signaling. ..
  6. Schönbauer C, Distler J, Jährling N, Radolf M, Dodt H, Frasch M, et al. Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insects. Nature. 2011;479:406-9 pubmed publisher
    ..We propose that Spalt proteins switch myofibres from tubular to fibrillar fate during development, a function potentially conserved in the vertebrate heart--a stretch-activated muscle sharing features with insect flight muscle. ..
  7. Crona F, Dahlberg O, Lundberg L, Larsson J, Mannervik M. Gene regulation by the lysine demethylase KDM4A in Drosophila. Dev Biol. 2013;373:453-63 pubmed publisher
    ..Our results show that a modest increase in global H3K36me3 levels is compatible with viability, fertility, and the expression of most genes, whereas decreased H3K36me3 levels are detrimental in males. ..
  8. Xun Z, Sowell R, Kaufman T, Clemmer D. Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease. Mol Cell Proteomics. 2008;7:1191-203 pubmed publisher be directly involved in A53T alpha-synuclein-mediated toxicity and PD; three up-regulated proteins (muscle LIM protein at 60A, manganese-superoxide dismutase, and troponin T) and two down-regulated proteins (chaoptin and retinal ..
  9. Bulchand S, Menon S, George S, Chia W. Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. J Cell Sci. 2010;123:2697-707 pubmed publisher
    ..We speculate that mute regulates terminal muscle differentiation possibly through heterochromatic reorganisation. ..

More Information


  1. Arber S, Caroni P. Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. Genes Dev. 1996;10:289-300 pubmed
    ..In this study we have analyzed the binding properties of LIM motifs in the cellular environment. We show that MLP, CRP, and betaCRP define a subclass of LIM-only proteins with unique dual subcellular localization in the nucleus ..
  2. Stronach B, Renfranz P, Lilly B, Beckerle M. Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis. Mol Biol Cell. 1999;10:2329-42 pubmed
    ..Previously, we characterized two members of the Drosophila CRP family, the muscle LIM proteins Mlp60A and Mlp84B, which show restricted expression in differentiating muscle lineages...
  3. Keller C, Erickson M, Abmayr S. Misexpression of nautilus induces myogenesis in cardioblasts and alters the pattern of somatic muscle fibers. Dev Biol. 1997;181:197-212 pubmed
    ..Moreover, many cardioblasts express increased levels of muscle-specific genes such as myosin, actin 57B, and Mlp60A, a protein that is restricted to the somatic, visceral, and pharyngeal muscles...
  4. Lin M, Bour B, Abmayr S, Storti R. Ectopic expression of MEF2 in the epidermis induces epidermal expression of muscle genes and abnormal muscle development in Drosophila. Dev Biol. 1997;182:240-55 pubmed
    ..We also find that the level of MEF2 in the mesoderm and/or muscles in embryos is critical to body-wall muscle formation; however, no effect is observed on the development of the visceral muscle or dorsal vessel. ..
  5. Ma L, Ma J, Xu K. Effect of spaceflight on the circadian rhythm, lifespan and gene expression of Drosophila melanogaster. PLoS ONE. 2015;10:e0121600 pubmed publisher
  6. Xun Z, Kaufman T, Clemmer D. Proteome response to the panneural expression of human wild-type alpha-synuclein: a Drosophila model of Parkinson's disease. J Proteome Res. 2008;7:3911-21 pubmed publisher
    ..The observed alterations in both pathology-associated and novel proteins may shed light on the pathological roles of alpha-synuclein that may lead to the development of diagnostic strategies at the presymptomatic stage. ..
  7. Weiskirchen R, Günther K. The CRP/MLP/TLP family of LIM domain proteins: acting by connecting. Bioessays. 2003;25:152-62 pubmed
  8. Stronach B, Siegrist S, Beckerle M. Two muscle-specific LIM proteins in Drosophila. J Cell Biol. 1996;134:1179-95 pubmed
    ..b>Mlp60A encodes a protein with a single LIM domain linked to a glycine-rich region...