mitochondrial transcription factor A


Gene Symbol: mitochondrial transcription factor A
Description: mitochondrial transcription factor A
Alias: CG4217, D-mtTFA, Dmel\CG4217, MTTFA, Tfam, d-TFAM, d-mttfa, d-tfam, mtTFA, mttfa, tfam, mitochondrial transcription factor A, CG4217-PA, CG4217-PB, TFAM-PA, TFAM-PB, mitochondiral transcription fctor a, mitochondrial transcription factor
Species: fruit fly

Top Publications

  1. Takata K, Yoshida H, Hirose F, Yamaguchi M, Kai M, Oshige M, et al. Drosophila mitochondrial transcription factor A: characterization of its cDNA and expression pattern during development. Biochem Biophys Res Commun. 2001;287:474-83 pubmed
    We cloned a cDNA for Drosophila mitochondrial transcription factor A (D-mtTFA) and characterized the recombinant protein. In Drosophila Kc cells, D-mtTFA was localized in the mitochondria, but not in the nucleus...
  2. Matsushima Y, Goto Y, Kaguni L. Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM). Proc Natl Acad Sci U S A. 2010;107:18410-5 pubmed publisher
    ..RNAi knockdown of Lon results in increased abundance of mitochondrial transcription factor A (TFAM) and mtDNA copy number...
  3. Bruni F, Manzari C, Filice M, Loguercio Polosa P, Colella M, Carmone C, et al. D-MTERF5 is a novel factor modulating transcription in Drosophila mitochondria. Mitochondrion. 2012;12:492-9 pubmed publisher
    ..Co-regulation by DREF (DNA Replication-related Element binding Factor) of D-MTERF5 and DmTTF implies that expression of the two factors needs to be co-ordinated to ensure fine modulation of Drosophila mitochondrial transcription. ..
  4. Banerjee K, Ayyub C, Sengupta S, Kolthur Seetharam U. Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles. Mol Cell Biol. 2013;33:252-64 pubmed publisher
    ..In summary, we show that fat body dSir2 is a master regulator of organismal energy homeostasis and is required for maintaining the metabolic regulatory network across tissues. ..
  5. Icreverzi A, de la Cruz A, Van Voorhies W, Edgar B. Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress. Cell Cycle. 2012;11:554-68 pubmed publisher
    ..hyperactivity leads to increased mitochondrial biogenesis (mitobiogenesis), mitochondrial mass, NRF-1 activity (Tfam transcript levels) and metabolic activity in Drosophila, whereas loss of CycD/Cdk4 activity has the opposite ..
  6. Cagin U, Duncan O, Gatt A, Dionne M, Sweeney S, Bateman J. Mitochondrial retrograde signaling regulates neuronal function. Proc Natl Acad Sci U S A. 2015;112:E6000-9 pubmed publisher
    ..Thus, mitochondrial retrograde signaling regulates neuronal activity and can be manipulated to enhance neuronal function, despite mitochondrial impairment. ..
  7. Zhang F, Qi Y, Zhou K, Zhang G, Linask K, Xu H. The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM. EMBO Rep. 2015;16:520-7 pubmed publisher
    ..Knocking down prune in cultured cells reduces mitochondrial transcription factor A (TFAM) and mitochondrial DNA (mtDNA) levels...
  8. Martinez Azorin F, Calleja M, Hernández Sierra R, Farr C, Kaguni L, Garesse R. Muscle-specific overexpression of the catalytic subunit of DNA polymerase ? induces pupal lethality in Drosophila melanogaster. Arch Insect Biochem Physiol. 2013;83:127-37 pubmed publisher
    ..level that is accompanied by a corresponding decrease in the levels of the nucleoid-binding protein mitochondrial transcription factor A (mtTFA)...
  9. Wang C, Yolitz J, Alberico T, Laslo M, Sun Y, Wheeler C, et al. Cranberry interacts with dietary macronutrients to promote healthy aging in Drosophila. J Gerontol A Biol Sci Med Sci. 2014;69:945-54 pubmed publisher
    ..Our study reveals an interaction of cranberry with dietary macronutrients and stresses the importance of considering diet composition in designing interventions for promoting healthy aging. ..

More Information


  1. Mensah L, Davison C, Fan S, Morris J, Goberdhan D, Wilson C. Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster. PLoS ONE. 2015;10:e0143818 pubmed publisher
  2. Brown A, Baumbach J, Cook P, Ligoxygakis P. Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections. PLoS ONE. 2009;4:e4490 pubmed publisher
    ..Our results show that NO release through STS may reflect an evolutionary conserved process. Moreover, STS could be explored to address immune phenotypes related to infection and may offer ways to boost natural immunity. ..
  3. Kim J, Cunningham R, James B, Wyder S, Gibson J, Niehuis O, et al. Functional characterization of transcription factor motifs using cross-species comparison across large evolutionary distances. PLoS Comput Biol. 2010;6:e1000652 pubmed publisher
    ..We also apply the framework to find motifs associated with socially regulated gene sets in the honeybee, Apis mellifera, using comparisons with Nasonia, a solitary species, to identify honeybee-specific associations. ..
  4. Fox R, Andrew D. Changes in organelle position and epithelial architecture associated with loss of CrebA. Biol Open. 2015;4:317-30 pubmed publisher
    ..Correspondingly, removal of several tetraspanins gives partial rescue of the CrebA SJ phenotype, supporting a role for tetraspanins in SJ organization. ..
  5. Doroszuk A, Jonker M, Pul N, Breit T, Zwaan B. Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. BMC Genomics. 2012;13:167 pubmed publisher
    ..The results suggest that natural genetic variation for SR and lifespan can operate through similar transcriptional mechanisms as those of dietary restriction and life-extending mutations. ..
  6. de Castro I, Costa A, Celardo I, Tufi R, Dinsdale D, Loh S, et al. Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants. Cell Death Dis. 2013;4:e873 pubmed publisher
    ..We conclude that Ref(2)P is a crucial downstream effector of a pathway involving Pink1 and Parkin and is responsible for the maintenance of a viable pool of cellular mitochondria by promoting their aggregation and autophagic clearance. ..
  7. Craigen W, Graham B. Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions. J Bioenerg Biomembr. 2008;40:207-12 pubmed publisher
    ..Striking similarities to mouse VDAC mutants can be found that emphasize the conservation of function over a long evolutionary time frame. ..
  8. Thomas R, Andrews L, Burman J, Lin W, Pallanck L. PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix. PLoS Genet. 2014;10:e1004279 pubmed publisher
    ..Our findings thus suggest that Lon plays an essential role in regulating the PINK1-Parkin pathway by promoting the degradation of PINK1 in the matrix of healthy mitochondria. ..
  9. Tufi R, Gandhi S, de Castro I, Lehmann S, Angelova P, Dinsdale D, et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat Cell Biol. 2014;16:157-66 pubmed publisher
    ..We propose that targeting strategies enhancing nucleotide synthesis pathways may reverse mitochondrial dysfunction and rescue neurodegeneration in PD and, potentially, other diseases linked to mitochondrial impairment. ..
  10. Takata K, Inoue Y, Hirose F, Murakami S, Shimanouchi K, Sakimoto I, et al. Spatio-temporal expression of Drosophila mitochondrial transcription factor A during development. Cell Biol Int. 2003;27:361-74 pubmed
    We previously reported cloning of the Drosophila mitochondrial transcription factor A (D-mtTFA) gene, and characterization of a recombinant protein...
  11. Goto A, Matsushima Y, Kadowaki T, Kitagawa Y. Drosophila mitochondrial transcription factor A (d-TFAM) is dispensable for the transcription of mitochondrial DNA in Kc167 cells. Biochem J. 2001;354:243-8 pubmed
    We have cloned cDNA encoding Drosophila mitochondrial (mt) transcription factor A (d-TFAM)...
  12. Matsushima Y, Garesse R, Kaguni L. Drosophila mitochondrial transcription factor B2 regulates mitochondrial DNA copy number and transcription in schneider cells. J Biol Chem. 2004;279:26900-5 pubmed
    ..In a comparative experiment, we find that overexpression of Drosophila mitochondrial transcription factor A (d-TFAM) increases mtDNA copy number with no significant effect on mitochondrial transcripts...
  13. Martinez Azorin F, Calleja M, Hernández Sierra R, Farr C, Kaguni L, Garesse R. Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion. J Neurochem. 2008;105:165-76 pubmed accompanied by a significant mtDNA depletion, and a corresponding decrease in the levels of mitochondrial transcription factor A (mtTFA)...
  14. Matsuda T, Kanki T, Tanimura T, Kang D, Matsuura E. Effects of overexpression of mitochondrial transcription factor A on lifespan and oxidative stress response in Drosophila melanogaster. Biochem Biophys Res Commun. 2013;430:717-21 pubmed publisher
    b>Mitochondrial transcription factor A (TFAM) plays a role in the maintenance of mitochondrial DNA (mtDNA) by packaging mtDNA, forming the mitochondrial nucleoid...
  15. Sessa L, Bianchi M. The evolution of High Mobility Group Box (HMGB) chromatin proteins in multicellular animals. Gene. 2007;387:133-40 pubmed
    ..The organization of HMGB genes was very conserved during Metazoan evolution, with the only deviations appearing in Caenorhabditis and Dipteran (Drosophila and Anopheles) species. ..