Gene Symbol: mip40
Description: Myb-interacting protein 40
Alias: CG15119, Dmel\CG15119, Mip40, p40, Myb-interacting protein 40, CG15119-PA, mip40-PA
Species: fruit fly

Top Publications

  1. Beall E, Manak J, Zhou S, Bell M, Lipsick J, Botchan M. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature. 2002;420:833-7 pubmed
    ..These data provide evidence that specific protein complexes bound to replication enhancer elements work together with the general replication machinery for site-specific origin utilization during replication. ..
  2. Beall E, Bell M, Georlette D, Botchan M. Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. Genes Dev. 2004;18:1667-80 pubmed
    ..Together, these data support a model in which DmMyb activates a repressive complex containing Mip130 into a complex competent to support replication at specific loci in a temporally and developmentally proscribed manner. ..
  3. Korenjak M, Taylor Harding B, Binné U, Satterlee J, Stevaux O, Aasland R, et al. Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell. 2004;119:181-93 pubmed
    ..These results reveal an extensive evolutionary conservation of specific pRb repressor complexes that physically combine subunits with established roles in the regulation of transcription, DNA replication, and chromatin structure. ..
  4. Beall E, Lewis P, Bell M, Rocha M, Jones D, Botchan M. Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. Genes Dev. 2007;21:904-19 pubmed
    ..Here, we identified a mutation in mip40 and generated a mutation in mip120, two additional MMB subunits...
  5. Korenjak M, Brehm A. E2F-Rb complexes regulating transcription of genes important for differentiation and development. Curr Opin Genet Dev. 2005;15:520-7 pubmed
  6. Blanchard D, Georlette D, Antoszewski L, Botchan M. Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment. Proc Natl Acad Sci U S A. 2014;111:E4234-43 pubmed publisher
    ..Cytolocalization experiments suggest the presence of site-specific differential composition of MMB in polytene chromosomes where some loci were bound by a Myb-containing or alternatively, an E2f2 and L(3)mbt form of the complex. ..
  7. Andrejka L, Wen H, Ashton J, Grant M, Iori K, Wang A, et al. Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex. Proc Natl Acad Sci U S A. 2011;108:17438-43 pubmed publisher
    ..Therefore, our results imply that the specific interaction of the C terminus of Myb with the MuvB/dREAM core complex may provide an attractive target for the development of cancer therapeutics. ..
  8. Lee H, Ragusano L, Martinez A, Gill J, Dimova D. A dual role for the dREAM/MMB complex in the regulation of differentiation-specific E2F/RB target genes. Mol Cell Biol. 2012;32:2110-20 pubmed publisher
    ..First, it is required for the stability of the repressive dE2F2/RBF complexes at their promoters during S phase. Second, we find that dREAM is indispensable for both transcriptional repression mechanisms employed at these genes. ..
  9. Bohla D, Herold M, Panzer I, Buxa M, Ali T, Demmers J, et al. A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking. PLoS ONE. 2014;9:e107765 pubmed publisher
    ..Furthermore, the enhancer blocking function of insulators is associated with nucleosomal depletion and requires NURF and dREAM. ..

More Information


  1. Chen X, Lu C, Morillo Prado J, Eun S, Fuller M. Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. Development. 2011;138:2441-50 pubmed publisher
    ..Together, the action of the tMAC and tTAF cell type-specific chromatin and transcription machinery leads to loss of Polycomb and release of stalled Pol II from the terminal differentiation gene promoters, allowing robust transcription. ..
  2. Lewis P, Sahoo D, Geng C, Bell M, Lipsick J, Botchan M. Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex. Mol Cell Biol. 2012;32:3218-27 pubmed publisher
    ..Furthermore, these findings support a model in which the Lin-52 and Myb proteins counteract the repressive activities of the other members of the MMB/dREAM complex at specific genomic loci in a developmentally controlled manner. ..