Mip

Summary

Gene Symbol: Mip
Description: Myoinhibiting peptide precursor
Alias: ASB, AST-B, Ast-B, AstB, AstB-1, CG6456, DAP-B, DmMIP1, DmMIP2, DmMIP3, DmMIP4, DmMIP5, Dmel\CG6456, Drm-MIP, Drm-MIP-1, Drm-MIP-2, Drm-MIP-3, Drm-MIP-4, Drm-MIP-5, MIP, MIP-1, MIP-2, MIP-3, MIP-4, MIP-5, mip, myoinhibiting peptide precursor, CG6456-PA, Drostatin-B1, Drostatin-B3, Drostatin-B4, Drostatin-B5, Mip-PA, Mip-like peptide, allatostatin (B-type), allatostatin B, allatostatin B-1, allatostatin cricket-type, allatostatin-B, allatostatin-B1, allostatin B, drostatin-B2, mioinhibiting peptide precursor, myoinhibiting peptide, myoinhibitory peptide
Species: fruit fly

Top Publications

  1. Cazzamali G, Grimmelikhuijzen C. Molecular cloning and functional expression of the first insect FMRFamide receptor. Proc Natl Acad Sci U S A. 2002;99:12073-8 pubmed
    ..To our knowledge, this article is the first report on the molecular identification of an invertebrate FMRFamide receptor. ..
  2. Iversen A, Cazzamali G, Williamson M, Hauser F, Grimmelikhuijzen C. Molecular identification of the first insect ecdysis triggering hormone receptors. Biochem Biophys Res Commun. 2002;299:924-31 pubmed
    ..Ecdysis (cuticle shedding) is an important behaviour, allowing growth and metamorphosis in insects and other arthropods. Our paper is the first report on the molecular identification of ecdysis triggering hormone receptors from insects. ..
  3. Williamson M, Lenz C, Winther A, Nässel D, Grimmelikhuijzen C, Winther M. Molecular cloning, genomic organization, and expression of a B-type (cricket-type) allatostatin preprohormone from Drosophila melanogaster. Biochem Biophys Res Commun. 2001;281:544-50 pubmed
    ..This is the first published report of a B-type allatostatin preprohormone in insects, and the first paper describing the presence of B-type allatostatins in a representative of the insect order Diptera (flies). ..
  4. Baggerman G, Cerstiaens A, De Loof A, Schoofs L. Peptidomics of the larval Drosophila melanogaster central nervous system. J Biol Chem. 2002;277:40368-74 pubmed
    ..This neuropeptide expression profiling study also opens perspectives for other eukaryotic model systems, for which genome projects are completed or in progress. ..
  5. Santos J, Vömel M, Struck R, Homberg U, Nässel D, Wegener C. Neuroarchitecture of peptidergic systems in the larval ventral ganglion of Drosophila melanogaster. PLoS ONE. 2007;2:e695 pubmed
    ..The data can further be useful to identify colocalized transmitters and receptors, and develop peptidergic neurons as new landmarks. ..
  6. Carlsson M, Diesner M, Schachtner J, Nassel D. Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits. J Comp Neurol. 2010;518:3359-80 pubmed publisher
    ..These were short neuropeptide F, tachykinin related peptide, allatostatin A, myoinhibitory peptide, SIFamide, IPNamide, and myosuppressin...
  7. Rosenkilde C, Cazzamali G, Williamson M, Hauser F, Søndergaard L, DeLotto R, et al. Molecular cloning, functional expression, and gene silencing of two Drosophila receptors for the Drosophila neuropeptide pyrokinin-2. Biochem Biophys Res Commun. 2003;309:485-94 pubmed
    ..The two Drosophila pyrokinin receptors are, to our knowledge, the first invertebrate pyrokinin receptors to be identified. ..
  8. Baggerman G, Boonen K, Verleyen P, De Loof A, Schoofs L. Peptidomic analysis of the larval Drosophila melanogaster central nervous system by two-dimensional capillary liquid chromatography quadrupole time-of-flight mass spectrometry. J Mass Spectrom. 2005;40:250-60 pubmed
    ..This clearly demonstrates that the two-dimensional capillary LC approach enhances the coverage of the peptidomic analysis. ..
  9. Lenz C, Williamson M, Grimmelikhuijzen C. Molecular cloning and genomic organization of an allatostatin preprohormone from Drosophila melanogaster. Biochem Biophys Res Commun. 2000;273:1126-31 pubmed
    ..This is the first report on an allatostatin preprohormone from Drosophila. ..

More Information

Publications38

  1. Vömel M, Wegener C. Neurotransmitter-induced changes in the intracellular calcium concentration suggest a differential central modulation of CCAP neuron subsets in Drosophila. Dev Neurobiol. 2007;67:792-808 pubmed
    ..Our results suggest that N(CCAP) express functional receptors for ACh, glutamate, and GABA, and indicate that these transmitters are involved in a context-dependent regulation of functionally distinct N(CCAP) subsets. ..
  2. Iversen A, Cazzamali G, Williamson M, Hauser F, Grimmelikhuijzen C. Molecular cloning and functional expression of a Drosophila receptor for the neuropeptides capa-1 and -2. Biochem Biophys Res Commun. 2002;299:628-33 pubmed
    ..Because capa-1 and -2 and related insect neuropeptides stimulate fluid secretion in insect Malpighian (renal) tubules, the identification of this first insect capa receptor will advance our knowledge on insect renal function. ..
  3. Kim Y, Bartalska K, Audsley N, Yamanaka N, Yapici N, Lee J, et al. MIPs are ancestral ligands for the sex peptide receptor. Proc Natl Acad Sci U S A. 2010;107:6520-5 pubmed publisher
    ..We conclude that MIPs are evolutionarily conserved ligands for SPR, which are likely to mediate functions other than the regulation of female reproductive behaviors. ..
  4. Birse R, Johnson E, Taghert P, Nassel D. Widely distributed Drosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides. J Neurobiol. 2006;66:33-46 pubmed
    ..Our findings suggest that DTKR is a DTK receptor in Drosophila and that this ligand-receptor system plays multiple functional roles. ..
  5. J rgensen L, Hauser F, Cazzamali G, Williamson M, Grimmelikhuijzen C. Molecular identification of the first SIFamide receptor. Biochem Biophys Res Commun. 2006;340:696-701 pubmed publisher
    ..This paper is the first report on the identification of a SIFamide receptor...
  6. Poels J, Van Loy T, Vandersmissen H, Van Hiel B, Van Soest S, Nachman R, et al. Myoinhibiting peptides are the ancestral ligands of the promiscuous Drosophila sex peptide receptor. Cell Mol Life Sci. 2010;67:3511-22 pubmed publisher
    ..b>MIP transcripts occur in male and female central nervous system, possibly acting as endogenous SPR ligands...
  7. Johnson E, Shafer O, Trigg J, Park J, Schooley D, Dow J, et al. A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling. J Exp Biol. 2005;208:1239-46 pubmed
    ..Therefore, it appears that both the molecular details as well as the functional organization of CGRP signaling have been conserved. ..
  8. Yew J, Wang Y, Barteneva N, Dikler S, Kutz Naber K, Li L, et al. Analysis of neuropeptide expression and localization in adult drosophila melanogaster central nervous system by affinity cell-capture mass spectrometry. J Proteome Res. 2009;8:1271-84 pubmed publisher
    ..Neuropeptide profiling also was performed on targeted populations of cells which were enriched with immunoaffinity purification using a genetically expressed marker. ..
  9. Kolodziejczyk A, Nassel D. A novel wide-field neuron with branches in the lamina of the Drosophila visual system expresses myoinhibitory peptide and may be associated with the clock. Cell Tissue Res. 2011;343:357-69 pubmed publisher
    ..neuron that has wide-field tangential arborizations just distal to the lamina neuropil and that expresses myoinhibitory peptide (MIP)...
  10. Oh Y, Yoon S, Zhang Q, Chae H, Daubnerová I, Shafer O, et al. A homeostatic sleep-stabilizing pathway in Drosophila composed of the sex peptide receptor and its ligand, the myoinhibitory peptide. PLoS Biol. 2014;12:e1001974 pubmed publisher
    ..Mutants lacking either the SPR or its central ligand, myoinhibitory peptide (MIP), fall asleep normally, but have difficulty in maintaining a sleep-like state...
  11. Salisbury J, Boggio K, Hsu Y, Quijada J, Sivachenko A, Gloeckner G, et al. A rapid MALDI-TOF mass spectrometry workflow for Drosophila melanogaster differential neuropeptidomics. Mol Brain. 2013;6:60 pubmed publisher
    ..While the data analysis methods should be compatible with other sample preparations, the presented sample preparation method was sufficient to identify previously unconfirmed D. melanogaster neuropeptides. ..
  12. Thomas A, Lee P, Dalton J, Nomie K, Stoica L, Costa Mattioli M, et al. A versatile method for cell-specific profiling of translated mRNAs in Drosophila. PLoS ONE. 2012;7:e40276 pubmed publisher
    ..This method can be used to determine the unique translatome profiles in different cell-types under varied physiological, pharmacological and pathological conditions. ..
  13. Hansen K, Hauser F, Williamson M, Weber S, Grimmelikhuijzen C. The Drosophila genes CG14593 and CG30106 code for G-protein-coupled receptors specifically activated by the neuropeptides CCHamide-1 and CCHamide-2. Biochem Biophys Res Commun. 2011;404:184-9 pubmed publisher
  14. Ewer J. Behavioral endocrinology: lighting up peptidergic neurons that mediate a complex behavior. Curr Biol. 2006;16:R682-4 pubmed
  15. Kim D, Han M, Lee G, Lee S, Kim Y, Adams M. Rescheduling Behavioral Subunits of a Fixed Action Pattern by Genetic Manipulation of Peptidergic Signaling. PLoS Genet. 2015;11:e1005513 pubmed publisher
    ..of the FAP: kinin (aka drosokinin, leucokinin) neurons regulate pre-ecdysis behavior and CAMB neurons (CCAP, AstCC, MIP, and Bursicon) initiate the switch to ecdysis behavior...
  16. Min S, Chae H, Jang Y, Choi S, Lee S, Jeong Y, et al. Identification of a Peptidergic Pathway Critical to Satiety Responses in Drosophila. Curr Biol. 2016;26:814-20 pubmed publisher
    ..Silencing of myoinhibitory peptide (MIP) neurons significantly increased BW through augmented food intake and fat storage...
  17. Reiher W, Shirras C, Kahnt J, Baumeister S, Isaac R, Wegener C. Peptidomics and peptide hormone processing in the Drosophila midgut. J Proteome Res. 2011;10:1881-92 pubmed publisher
    ..By MS/MS fragmentation, we found 24 peptides from 9 different preprohormones in midgut extracts, including MIP-4 and 2 forms of AST-C. DH(31), CCHamide1 and CCHamide2 are biochemically characterized for the first time...
  18. Wegener C, Gorbashov A. Molecular evolution of neuropeptides in the genus Drosophila. Genome Biol. 2008;9:R131 pubmed publisher
    ..The last common ancestor of Drosophila obviously had a set of neuropeptides and peptide hormones identical to that of modern fruit flies. This is remarkable, since drosophilid flies have adapted to very different environments. ..
  19. Kondo S, Ueda R. Highly improved gene targeting by germline-specific Cas9 expression in Drosophila. Genetics. 2013;195:715-21 pubmed publisher
    ..3-23%. Our method is readily scalable to high-throughput gene targeting, thereby accelerating comprehensive functional annotation of the Drosophila genome. ..
  20. Veverytsa L, Allan D. Retrograde BMP signaling controls Drosophila behavior through regulation of a peptide hormone battery. Development. 2011;138:3147-57 pubmed publisher
    ..of CCAP neurons (CCAP-ENs) is required to cell-autonomously upregulate expression of the peptide hormones CCAP, Mip and Bursicon ?...
  21. Bowser P, Tobe S. Bioinformatic analysis of neuropeptide and receptor expression profiles during midgut metamorphosis in Drosophila melanogaster. Peptides. 2006;27:583-9 pubmed
    ..small but significant changes in the expression of the peptides diuretic hormone, FGLa-type allatostatins, myoinhibiting peptide, ecdysis-triggering hormone, drosokinin and the burs subunit of bursicon, as well as the receptors DAR-2, ..
  22. LaJeunesse D, Johnson B, Presnell J, Catignas K, Zapotoczny G. Peristalsis in the junction region of the Drosophila larval midgut is modulated by DH31 expressing enteroendocrine cells. BMC Physiol. 2010;10:14 pubmed publisher
    ..The Drosophila model system will allow for a further dissection of the digestion process and provide a better understanding of the mechanisms that regulate digestion in all organisms. ..
  23. Johnson E, Bohn L, Taghert P. Drosophila CG8422 encodes a functional diuretic hormone receptor. J Exp Biol. 2004;207:743-8 pubmed
    ..The identification of a Drosophila receptor for the DH neuropeptide provides a basis for genetic analysis of this critical factor's roles in maintaining physiological homeostasis. ..
  24. Egerod K, Reynisson E, Hauser F, Cazzamali G, Williamson M, Grimmelikhuijzen C. Molecular cloning and functional expression of the first two specific insect myosuppressin receptors. Proc Natl Acad Sci U S A. 2003;100:9808-13 pubmed
    ..To our knowledge, this paper is the first report on the molecular identification of specific insect myosuppressin receptors. ..
  25. Lu C, Fuller M. Recruitment of Mediator Complex by Cell Type and Stage-Specific Factors Required for Tissue-Specific TAF Dependent Gene Activation in an Adult Stem Cell Lineage. PLoS Genet. 2015;11:e1005701 pubmed publisher
    ..to act in a sequential hierarchy, with the testis activating Complex (tMAC), a cell type specific form of the Mip/dREAM general repressor, required to recruit Mediator subunits to the chromatin, and Mediator function required to ..
  26. Hussain A, Üçpunar H, Zhang M, Loschek L, Grunwald Kadow I. Neuropeptides Modulate Female Chemosensory Processing upon Mating in Drosophila. PLoS Biol. 2016;14:e1002455 pubmed publisher
    ..Together, our data show that neuropeptide-mediated modulation of peripheral chemosensory neurons increases a gravid female's preference for important nutrients, thereby ensuring optimal conditions for her growing progeny. ..
  27. Kahsai L, Winther A. Chemical neuroanatomy of the Drosophila central complex: distribution of multiple neuropeptides in relation to neurotransmitters. J Comp Neurol. 2011;519:290-315 pubmed publisher
    ..GABA, monoamines, and eight different neuropeptides; Drosophila tachykinin, short neuropeptide F, myoinhibitory peptide, allatostatin A, proctolin, SIFamide, neuropeptide F, and FMRFamide...
  28. Vömel M, Wegener C. Neuroarchitecture of aminergic systems in the larval ventral ganglion of Drosophila melanogaster. PLoS ONE. 2008;3:e1848 pubmed publisher
  29. Egerod K, Reynisson E, Hauser F, Williamson M, Cazzamali G, Grimmelikhuijzen C. Molecular identification of the first insect proctolin receptor. Biochem Biophys Res Commun. 2003;306:437-42 pubmed
    ..The Drosophila receptor reported here is the first invertebrate proctolin receptor to be identified. ..