midway

Summary

Gene Symbol: midway
Description: midway
Alias: CG13273, CG17937, CG17938, CG31991, CT39962, DGAT, DGAT1, Dgat1, Dmel\CG31991, Mdy, mdcds_3562, midway, CG31991-PA, CG31991-PB, CG31991-PC, CG31991-PE, diacylglycerol acyltransferase, mdy-PA, mdy-PB, mdy-PC, mdy-PE
Species: fruit fly

Top Publications

  1. Buszczak M, Lu X, Segraves W, Chang T, Cooley L. Mutations in the midway gene disrupt a Drosophila acyl coenzyme A: diacylglycerol acyltransferase. Genetics. 2002;160:1511-8 pubmed
    ..The midway gene encodes a protein similar to mammalian acyl coenzyme A: diacylglycerol acyltransferase (DGAT), which converts diacylglycerol (DAG) into triacylglycerol (TAG)...
  2. Beller M, Bulankina A, Hsiao H, Urlaub H, Jackle H, Kühnlein R. PERILIPIN-dependent control of lipid droplet structure and fat storage in Drosophila. Cell Metab. 2010;12:521-32 pubmed publisher
    ..We generated flies devoid of all PERILIPIN family members and show that they exhibit impaired yet functional body fat regulation. Our data reveal the existence of a basal and possibly ancient lipid homeostasis system. ..
  3. Wilfling F, Wang H, Haas J, Krahmer N, Gould T, Uchida A, et al. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell. 2013;24:384-99 pubmed publisher
    ..Our results explain how TG synthesis is coupled with LD growth and identify two distinct LD subpopulations based on their capacity for localized TG synthesis. ..
  4. Steinhauer J, Gijón M, Riekhof W, Voelker D, Murphy R, Treisman J. Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Mol Biol Cell. 2009;20:5224-35 pubmed publisher
    ..Our findings suggest that lysophospholipid acyltransferase activity is essential for germline development and could provide a mechanistic explanation for the etiology of the human MBOAT1 mutation. ..
  5. Lee H, Peng Y, Guo Y. Analysis of lipid droplet dynamics and functions in Drosophila melanogaster. Methods Cell Biol. 2013;116:53-69 pubmed publisher
  6. Tschapalda K, Zhang Y, Liu L, Golovnina K, Schlemper T, Eichmann T, et al. A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics. EBioMedicine. 2016;8:49-59 pubmed publisher
    ..experiments, RNA-Seq expression profiles suggested that the target of one of the small molecules was diacylglycerol acyltransferase 1 (DGAT1), a key enzyme in the production of triacylglycerols and prominent human drug target...
  7. Cinnamon E, Makki R, Sawala A, Wickenberg L, Blomquist G, Tittiger C, et al. Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling. PLoS Genet. 2016;12:e1006154 pubmed publisher
    ..Together, the findings in this study show how Spidey/Kar and FarO regulate the balance between the cell growth and lipid storage of larval oenocytes. ..
  8. Tekotte H, Berdnik D, Torok T, Buszczak M, Jones L, Cooley L, et al. Dcas is required for importin-alpha3 nuclear export and mechano-sensory organ cell fate specification in Drosophila. Dev Biol. 2002;244:396-406 pubmed
    ..We propose that mutations in house keeping genes often cause specific developmental phenotypes, such as those observed in many human genetic disorders. ..
  9. Tian Y, Bi J, Shui G, Liu Z, Xiang Y, Liu Y, et al. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. PLoS Genet. 2011;7:e1001364 pubmed publisher
    ..In summary, we have demonstrated a tissue-autonomous role of dSeipin in ectopic lipid storage in lipodystrophy. ..

More Information

Publications13

  1. Magny E, Pueyo J, Pearl F, Céspedes M, Niven J, Bishop S, et al. Conserved regulation of cardiac calcium uptake by peptides encoded in small open reading frames. Science. 2013;341:1116-20 pubmed publisher
    ..Such conservation suggests that the mechanisms for heart regulation are ancient and that smORFs may be a fundamental genome component that should be studied systematically. ..
  2. Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, et al. Seipin promotes adipose tissue fat storage through the ER Ca²?-ATPase SERCA. Cell Metab. 2014;19:861-71 pubmed publisher
    ..Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis. ..
  3. Baumbach J, Xu Y, Hehlert P, Kühnlein R. G?q, G?1 and Plc21C control Drosophila body fat storage. J Genet Genomics. 2014;41:283-92 pubmed publisher
    ..Plc21C affected the iCa(2+) of fat body cells and the expression profile of the lipid metabolism effector genes midway and brummer, which results in severely obese or lean flies...
  4. Bailey A, Koster G, Guillermier C, Hirst E, Macrae J, Lechene C, et al. Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila. Cell. 2015;163:340-53 pubmed publisher
    ..This study reveals an antioxidant role for lipid droplets that could be relevant in many different biological contexts. ..