Gene Symbol: midway
Alias: CG13273, CG17937, CG17938, CG31991, CT39962, DGAT, DGAT1, Dgat1, Dmel\CG31991, Mdy, mdcds_3562, midway, CG31991-PA, CG31991-PB, CG31991-PC, CG31991-PE, diacylglycerol acyltransferase, mdy-PA, mdy-PB, mdy-PC, mdy-PE
Species: fruit fly
Buszczak M, Lu X, Segraves W, Chang T, Cooley L. Mutations in the midway gene disrupt a Drosophila acyl coenzyme A: diacylglycerol acyltransferase. Genetics. 2002;160:1511-8 pubmed
..The midway gene encodes a protein similar to mammalian acyl coenzyme A: diacylglycerol acyltransferase (DGAT), which converts diacylglycerol (DAG) into triacylglycerol (TAG)...
Beller M, Bulankina A, Hsiao H, Urlaub H, Jackle H, Kühnlein R. PERILIPIN-dependent control of lipid droplet structure and fat storage in Drosophila. Cell Metab. 2010;12:521-32 pubmed publisher
..We generated flies devoid of all PERILIPIN family members and show that they exhibit impaired yet functional body fat regulation. Our data reveal the existence of a basal and possibly ancient lipid homeostasis system. ..
Wilfling F, Wang H, Haas J, Krahmer N, Gould T, Uchida A, et al
. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell. 2013;24:384-99 pubmed publisher
..Our results explain how TG synthesis is coupled with LD growth and identify two distinct LD subpopulations based on their capacity for localized TG synthesis. ..
Steinhauer J, Gijón M, Riekhof W, Voelker D, Murphy R, Treisman J. Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Mol Biol Cell. 2009;20:5224-35 pubmed publisher
..Our findings suggest that lysophospholipid acyltransferase activity is essential for germline development and could provide a mechanistic explanation for the etiology of the human MBOAT1 mutation. ..
Lee H, Peng Y, Guo Y. Analysis of lipid droplet dynamics and functions in Drosophila melanogaster. Methods Cell Biol. 2013;116:53-69 pubmed publisher
Tschapalda K, Zhang Y, Liu L, Golovnina K, Schlemper T, Eichmann T, et al
. A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics. EBioMedicine. 2016;8:49-59 pubmed publisher
..experiments, RNA-Seq expression profiles suggested that the target of one of the small molecules was diacylglycerol acyltransferase 1 (DGAT1), a key enzyme in the production of triacylglycerols and prominent human drug target...
Cinnamon E, Makki R, Sawala A, Wickenberg L, Blomquist G, Tittiger C, et al
. Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling. PLoS Genet. 2016;12:e1006154 pubmed publisher
..Together, the findings in this study show how Spidey/Kar and FarO regulate the balance between the cell growth and lipid storage of larval oenocytes. ..
Tekotte H, Berdnik D, Torok T, Buszczak M, Jones L, Cooley L, et al
. Dcas is required for importin-alpha3 nuclear export and mechano-sensory organ cell fate specification in Drosophila. Dev Biol. 2002;244:396-406 pubmed
..We propose that mutations in house keeping genes often cause specific developmental phenotypes, such as those observed in many human genetic disorders. ..
Tian Y, Bi J, Shui G, Liu Z, Xiang Y, Liu Y, et al
. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. PLoS Genet. 2011;7:e1001364 pubmed publisher
..In summary, we have demonstrated a tissue-autonomous role of dSeipin in ectopic lipid storage in lipodystrophy. ..