Gene Symbol: mia
Description: meiosis I arrest
Alias: CG10390, Dmel\CG10390, Mia, TAF, TAF60-2, TAF6L, TAF[[II]], TAF[[II]]60-2, TFIID, Taf60-2, Taf6L, dTAF6L, dTAF[[II]]60, dTAF[[II]]60-2, dmTAF6b, ms(3)570, meiosis I arrest, CG10390-PA, CG10390-PB, CG10390-PC, TAF6-like, TBP-associated factor 6-like, TBP-associated factor 60kD-2, mia-PA, mia-PB, mia-PC
Species: fruit fly

Top Publications

  1. Lin T, Viswanathan S, Wood C, Wilson P, Wolf N, Fuller M. Coordinate developmental control of the meiotic cell cycle and spermatid differentiation in Drosophila males. Development. 1996;122:1331-41 pubmed
    Wild-type function of four Drosophila genes, spermatocyte arrest, cannonball, always early and meiosis I arrest, is required both for cell-cycle progression through the G2/M transition of meiosis I in males and for onset of spermatid ..
  2. Chen X, Hiller M, Sancak Y, Fuller M. Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation. Science. 2005;310:869-72 pubmed
    ..Here we show that testis-specific TAF (TBP-associated factor) homologs required for terminal differentiation of male germ cells may activate target gene ..
  3. White Cooper H, Schafer M, Alphey L, Fuller M. Transcriptional and post-transcriptional control mechanisms coordinate the onset of spermatid differentiation with meiosis I in Drosophila. Development. 1998;125:125-34 pubmed
    The aly, can, mia and sa genes of Drosophila are essential in males both for the G2-meiosis I transition and for onset of spermatid differentiation...
  4. Metcalf C, Wassarman D. Nucleolar colocalization of TAF1 and testis-specific TAFs during Drosophila spermatogenesis. Dev Dyn. 2007;236:2836-43 pubmed
    ..tTAFs are paralogs of generally expressed TAF subunits of transcription factor IID (TFIID)...
  5. Hiller M, Chen X, Pringle M, Suchorolski M, Sancak Y, Viswanathan S, et al. Testis-specific TAF homologs collaborate to control a tissue-specific transcription program. Development. 2004;131:5297-308 pubmed
    ..We propose that the products of the five Drosophila genes encoding testis TAF homologs collaborate in an alternative TAF-containing protein complex to regulate a testis-specific gene expression ..
  6. Theofel I, Bartkuhn M, Hundertmark T, Boettger T, Gärtner S, Leser K, et al. tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family. PLoS ONE. 2014;9:e108267 pubmed publisher
  7. Jiang J, White Cooper H. Transcriptional activation in Drosophila spermatogenesis involves the mutually dependent function of aly and a novel meiotic arrest gene cookie monster. Development. 2003;130:563-73 pubmed
    ..The nuclear localisation of Aly and Comr proteins are mutually dependent. Finally, we show that active RNA polymerase II is found in distinct domains in the nucleus that constitute a subset of the total Comr stained chromatin. ..
  8. Arya G, Lodico M, Ahmad O, Amin R, Tomkiel J. Molecular characterization of teflon, a gene required for meiotic autosome segregation in male Drosophila melanogaster. Genetics. 2006;174:125-34 pubmed publisher
    ..On the basis of these findings, we propose a role for Tef as a bridging molecule that holds autosome bivalents together via heterochromatic connections...
  9. Di Cara F, Cavaliere D, Galliero V, Polito L, Digilio F. Expressional and functional analysis of the male-specific cluster mst36F during Drosophila spermatogenesis. Insect Mol Biol. 2010;19:807-13 pubmed publisher
    ..We obtained a reduction of fertility in the transgenic adult males compared to the wild type. These data suggest that the Mst36Fa and Mst36Fb proteins may have an important role in the production of functional sperm. ..

More Information


  1. Moon S, Cho B, Min S, Lee D, Chung Y. The THO complex is required for nucleolar integrity in Drosophila spermatocytes. Development. 2011;138:3835-45 pubmed publisher
    ..Taken together, our study suggests that the Drosophila THO complex is necessary for proper spermatogenesis by contribution to the establishment or maintenance of nucleolar integrity rather than by nuclear mRNA export in spermatocytes...
  2. Hochheimer A, Tjian R. Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression. Genes Dev. 2003;17:1309-20 pubmed
  3. Jiang J, Benson E, Bausek N, Doggett K, White Cooper H. Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with always early. Development. 2007;134:1549-59 pubmed
    ..tomb and aly might be components of a complex paralogous to the Drosophila dREAM/Myb-MuvB and C. elegans DRM transcriptional regulatory complexes. ..
  4. Matsushita T, Fujii Taira I, Tanaka Y, Homma K, Natori S. Male-specific IDGF, a novel gene encoding a membrane-bound extracellular signaling molecule expressed exclusively in testis of Drosophila melanogaster. J Biol Chem. 2000;275:36934-41 pubmed
    ..Analysis using four meiotic arrest mutants, aly, can, mia, and sa suggested that MSI is involved in spermiogenesis, the final differentiation step of spermatogenesis...
  5. Xu S, Hafer N, Agunwamba B, Schedl P. The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster. PLoS Genet. 2012;8:e1003079 pubmed publisher
    ..Additionally, analysis of a partial loss of function orb2 mutant suggests that the orb2 differentiation phenotypes are independent of the earlier arrest in meiosis. ..
  6. Tora L. A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription. Genes Dev. 2002;16:673-5 pubmed
  7. Cann M, Chung E, Levin L. A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster. Dev Genes Evol. 2000;210:200-6 pubmed
    ..Evidence is also provided for positive selection at the locus on chromosome 2 which suggests this gene family is actively evolving and may play a novel role in spermatogenesis. ..
  8. White Cooper H, Leroy D, MacQueen A, Fuller M. Transcription of meiotic cell cycle and terminal differentiation genes depends on a conserved chromatin associated protein, whose nuclear localisation is regulated. Development. 2000;127:5463-73 pubmed
    ..We favour a model where aly may regulate cell cycle progression and terminal differentiation during male gametogenesis by regulating chromatin conformation in primary spermatocytes. ..
  9. Goodrich J, Tjian R. Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation. Nat Rev Genet. 2010;11:549-58 pubmed publisher
    ..Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions. ..
  10. Aoyagi N, Wassarman D. Developmental and transcriptional consequences of mutations in Drosophila TAF(II)60. Mol Cell Biol. 2001;21:6808-19 pubmed
    In vitro, the TAF(II)60 component of the TFIID complex contributes to RNA polymerase II transcription initiation by serving as a coactivator that interacts with specific activator proteins and possibly as a promoter selectivity factor ..