Gene Symbol: Mgat1
Description: Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 1
Alias: CG13431, Dmel\CG13431, GlcNAc-TI, GlcNAcT1, MGAT1, dMGAT1, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 1, CG13431-PA, Mgat1-PA, N-acetylglucosaminyltransferase I, UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I
Species: fruit fly
Sarkar M, Schachter H. Cloning and expression of Drosophila melanogaster UDP-GlcNAc:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I. Biol Chem. 2001;382:209-17 pubmed
..Comparison of the cDNA and genomic DNA sequences allowed the assignment of seven exons and six introns; all introns showed GT-AG splice site consensus sequences. This is the first insect GnT I gene to be cloned and expressed. ..
Sarkar M, Leventis P, Silvescu C, Reinhold V, Schachter H, Boulianne G. Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span. J Biol Chem. 2006;281:12776-85 pubmed
UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I (encoded by Mgat1) controls the synthesis of hybrid, complex, and paucimannose N-glycans...
Sarkar M, Iliadi K, Leventis P, Schachter H, Boulianne G. Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat11 null mutants and increases life span. Proc Natl Acad Sci U S A. 2010;107:9677-82 pubmed publisher
The enzyme UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I (GnT1, encoded by Mgat1) controls the synthesis of paucimannose N-glycans in Drosophila...
Ichimiya T, Manya H, Ohmae Y, Yoshida H, Takahashi K, Ueda R, et al
. The twisted abdomen phenotype of Drosophila POMT1 and POMT2 mutants coincides with their heterophilic protein O-mannosyltransferase activity. J Biol Chem. 2004;279:42638-47 pubmed
..These results demonstrate that the two dPOMTs function as a protein O-mannosyltransferase in association with each other, in vitro and in vivo, to generate and maintain normal muscle development. ..
Baas S, Sharrow M, Kotu V, Middleton M, Nguyen K, Flanagan Steet H, et al
. Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo. Development. 2011;138:553-63 pubmed publisher
..Furthermore, neuronal sff expression is dependent on transcellular signaling through a non-neural toll-like receptor, linking neural-specific glycan expression to a kinase activity that is induced in response to environmental cues. ..
Praveen K, Wen Y, Matera A. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep. 2012;1:624-31 pubmed publisher
..These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects. ..
Mortimer N, Kacsoh B, Keebaugh E, Schlenke T. Mgat1-dependent N-glycosylation of membrane components primes Drosophila melanogaster blood cells for the cellular encapsulation response. PLoS Pathog. 2012;8:e1002819 pubmed publisher
Lotti F, Imlach W, Saieva L, Beck E, Hao L, Li D, et al
. An SMN-dependent U12 splicing event essential for motor circuit function. Cell. 2012;151:440-54 pubmed publisher
..These findings directly link defective splicing of critical neuronal genes induced by SMN deficiency to motor circuit dysfunction, establishing a molecular framework for the selective pathology of SMA. ..
Parkinson W, Dear M, Rushton E, Broadie K. N-glycosylation requirements in neuromuscular synaptogenesis. Development. 2013;140:4970-81 pubmed publisher
..All complex and hybrid N-glycosylation requires MGAT1 (UDP-GlcNAc:?-3-D-mannoside-?1,2-N-acetylglucosaminyl-transferase I) function, and Mgat1 nulls are the most ..