Gene Symbol: mfrn
Description: mitoferrin
Alias: CG4963, Dmel\CG4963, HD35059, Mfrn, anon-EST:fe2H5, dmfrn, mitoferrin, CG4963-PA, anon-fast-evolving-2H5, mfrn-PA
Species: fruit fly

Top Publications

  1. Metzendorf C, Wu W, Lind M. Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression. Biochem J. 2009;421:463-71 pubmed publisher
    ..In the present study we identified a single mitoferrin gene (dmfrn) in the genome of Drosophila melanogaster, which is probably an orthologue of mfrn2...
  2. Maynard J, Pham T, Zheng T, Jockheck Clark A, Rankin H, Newgard C, et al. Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Dev Biol. 2010;339:295-306 pubmed publisher
  3. Shulman J, Chipendo P, Chibnik L, Aubin C, Tran D, Keenan B, et al. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. Am J Hum Genet. 2011;88:232-8 pubmed publisher
    ..Our strategy of coupling genome-wide association in humans with functional screening in a model organism is likely to be a powerful approach for gene discovery in AD and other complex genetic disorders. ..
  4. Metzendorf C, Lind M. Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. BMC Dev Biol. 2010;10:68 pubmed publisher
    ..Here we investigate the role of Drosophila mitoferrin (dmfrn), which is a mitochondrial carrier protein with an established role in the mitochondrial iron metabolism, ..
  5. Navarro J, Botella J, Metzendorf C, Lind M, Schneuwly S. Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Free Radic Biol Med. 2015;85:71-82 pubmed publisher
    ..that the inability to activate ferritin translation and the enhancement of mitochondrial iron uptake via mitoferrin upregulation were likely the key molecular events behind the iron-induced phenotype...
  6. Llorens J, Metzendorf C, Missirlis F, Lind M. Mitochondrial iron supply is required for the developmental pulse of ecdysone biosynthesis that initiates metamorphosis in Drosophila melanogaster. J Biol Inorg Chem. 2015;20:1229-38 pubmed publisher
    ..Here we show that mutants in Drosophila mitoferrin (dmfrn), the gene encoding a mitochondrial carrier protein implicated in mitochondrial iron import, fail to grow ..