Gene Symbol: mfr
Description: misfire
Alias: CG5747, Dmel\CG5747, Otoferlin, misfire, CG5747-PB, CG5747-PC, CG5747-PD, CG5747-PE, CG5747-PF, CG5747-PI, CG5747-PJ, mfr-PB, mfr-PC, mfr-PD, mfr-PE, mfr-PF, mfr-PI, mfr-PJ, otoferlin
Species: fruit fly

Top Publications

  1. Ohsako T, Hirai K, Yamamoto M. The Drosophila misfire gene has an essential role in sperm activation during fertilization. Genes Genet Syst. 2003;78:253-66 pubmed
    The male sterile mutation, misfire (mfr), of Drosophila melanogaster is a novel paternal effect, fertilization defective mutant that effects sperm head decondensation...
  2. Adolfsen B, Littleton J. Genetic and molecular analysis of the synaptotagmin family. Cell Mol Life Sci. 2001;58:393-402 pubmed
    ..Here we review the current literature on the function of the synaptotagmin family and discuss the implications for synaptic transmission and membrane trafficking. ..
  3. Adolfsen B, Saraswati S, Yoshihara M, Littleton J. Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment. J Cell Biol. 2004;166:249-60 pubmed
    ..In addition, the identification of a postsynaptic synaptotagmin suggests calcium-dependent membrane-trafficking functions on both sides of the synapse. ..
  4. Smith M, Wakimoto B. Complex regulation and multiple developmental functions of misfire, the Drosophila melanogaster ferlin gene. BMC Dev Biol. 2007;7:21 pubmed publisher
    ..Mammals have several ferlin genes and mutations in the human dysferlin (DYSF) and otoferlin (OTOF) genes result in muscular dystrophy and hearing loss, respectively...
  5. Demontis F, Piccirillo R, Goldberg A, Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech. 2013;6:1339-52 pubmed publisher
  6. Gokhale A, Mullin A, Zlatic S, Easley C, Merritt M, Raj N, et al. The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity. J Neurosci. 2015;35:7643-53 pubmed publisher
    ..Our results demonstrate that dysbindin/BLOC-1 expression defects result in altered cellular content of proteins of the vesicle fusion apparatus and therefore influence synaptic plasticity. ..
  7. Loppin B, Dubruille R, Horard B. The intimate genetics of Drosophila fertilization. Open Biol. 2015;5: pubmed publisher