Gene Symbol: Mer
Description: Merlin
Alias: BG01543, CG14228, D-Mer, Dmel\CG14228, Dmerlin, EMR2, Emr2, NF2, mer, merlin, BG01543, CG14228-PA, CG14228-PB, D merlin, Ezrin-moesin-radixin-2, Mer-PA, Mer-PB, Merlin/Neurofibromin 2, dmerlin
Species: fruit fly

Top Publications

  1. McCartney B, Fehon R. Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin. J Cell Biol. 1996;133:843-52 pubmed
    ..identified and characterized Drosophila homologues of moesin (Dmoesin) and of the NF2 tumor suppressor merlin (Dmerlin)...
  2. Wehr M, Holder M, Gailite I, Saunders R, Maile T, Ciirdaeva E, et al. Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila. Nat Cell Biol. 2013;15:61-71 pubmed
    ..As Sik kinases have been implicated in nutrient sensing, this suggests a link between the Hpo pathway and systemic growth control. ..
  3. Chen C, Gajewski K, Hamaratoglu F, Bossuyt W, Sansores Garcia L, Tao C, et al. The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. Proc Natl Acad Sci U S A. 2010;107:15810-5 pubmed publisher both crb mutant cells and Crb overexpressing tissues, whereas the other Hippo pathway components, Fat and Merlin, are unaffected...
  4. MacDougall N, Lad Y, Wilkie G, Francis Lang H, Sullivan W, Davis I. Merlin, the Drosophila homologue of neurofibromatosis-2, is specifically required in posterior follicle cells for axis formation in the oocyte. Development. 2001;128:665-73 pubmed
    ..We report that Drosophila Merlin is specifically required only within the posterior follicle cells to initiate axis formation...
  5. Baumgartner R, Poernbacher I, Buser N, Hafen E, Stocker H. The WW domain protein Kibra acts upstream of Hippo in Drosophila. Dev Cell. 2010;18:309-16 pubmed publisher
    ..The FERM domain proteins Expanded and Merlin appear to represent two different signaling branches that feed into the Hippo pathway...
  6. Genevet A, Polesello C, Blight K, Robertson F, Collinson L, Pichaud F, et al. The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci. 2009;122:2360-70 pubmed publisher
    ..Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms. ..
  7. Oh H, Irvine K. In vivo regulation of Yorkie phosphorylation and localization. Development. 2008;135:1081-8 pubmed publisher
    ..These results identify modulation of subcellular localization as a mechanism of Yki regulation, and establish that this regulation occurs in vivo through multiple sites of Warts-dependent phosphorylation on Yki. ..
  8. Polesello C, Tapon N. Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol. 2007;17:1864-70 pubmed
    ..Two band 4.1 related proteins, Merlin (Mer) and Expanded (Ex), have been proposed to act upstream of Hpo, which in turn activates Wts ([1] for review)...
  9. Fehon R, Oren T, LaJeunesse D, Melby T, McCartney B. Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method. Genetics. 1997;146:245-52 pubmed

More Information


  1. Jin Y, Dong L, Lu Y, Wu W, Hao Q, Zhou Z, et al. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. J Biol Chem. 2012;287:5784-96 pubmed publisher
  2. Ling C, Zheng Y, Yin F, Yu J, Huang J, Hong Y, et al. The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A. 2010;107:10532-7 pubmed publisher
    ..kinase cascade, in turn, is regulated by apical membrane-associated proteins such as the FERM domain proteins Merlin and Expanded (Ex), and the WW- and C2-domain protein Kibra...
  3. Willecke M, Hamaratoglu F, Sansores Garcia L, Tao C, Halder G. Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation. Proc Natl Acad Sci U S A. 2008;105:14897-902 pubmed publisher
    ..The Ds/Fj signaling system thus defines a cell-to-cell signaling mechanism that regulates the Hippo pathway, thereby contributing to the control of organ size. ..
  4. Pellock B, Buff E, White K, Hariharan I. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol. 2007;304:102-15 pubmed
    Mutations that inactivate either merlin (mer) or expanded (ex) result in increased cell growth and proliferation in Drosophila. Both Mer and Ex are members of the Band 4...
  5. Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine K. Delineation of a Fat tumor suppressor pathway. Nat Genet. 2006;38:1142-50 pubmed
    ..The tumor suppressors Merlin, expanded, hippo, salvador and mob as tumor suppressor also share multiple Fat pathway phenotypes but regulate ..
  6. LaJeunesse D, McCartney B, Fehon R. A systematic screen for dominant second-site modifiers of Merlin/NF2 phenotypes reveals an interaction with blistered/DSRF and scribbler. Genetics. 2001;158:667-79 pubmed
    b>Merlin, the Drosophila homologue of the human tumor suppressor gene Neurofibromatosis 2 (NF2), is required for the regulation of cell proliferation and differentiation...
  7. Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D. Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell. 2013;154:1342-55 pubmed publisher
    Although Merlin/NF2 was discovered two decades ago as a tumor suppressor underlying Neurofibromatosis type II, its precise molecular mechanism remains poorly understood...
  8. LaJeunesse D, McCartney B, Fehon R. Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization. J Cell Biol. 1998;141:1589-99 pubmed
    b>Merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene, is a member of the protein 4.1 superfamily that is most closely related to ezrin, radixin, and moesin (ERM)...
  9. Boggiano J, Vanderzalm P, Fehon R. Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. Dev Cell. 2011;21:888-95 pubmed publisher
    ..In S2 cells, Tao-1 mediates the effects of the upstream HSW components Merlin and Expanded, consistent with the idea that Tao-1 functions in tissues to regulate Hippo phosphorylation...
  10. Hamaratoglu F, Willecke M, Kango Singh M, Nolo R, Hyun E, Tao C, et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006;8:27-36 pubmed
    b>Merlin, the protein product of the Neurofibromatosis type-2 gene, acts as a tumour suppressor in mice and humans. Merlin is an adaptor protein with a FERM domain and it is thought to transduce a growth-regulatory signal...
  11. Deng Y, Matsui Y, Zhang Y, Lai Z. Hippo activation through homodimerization and membrane association for growth inhibition and organ size control. Dev Biol. 2013;375:152-9 pubmed publisher
    ..Moreover, loss- and gain-of-function studies indicate that upstream regulators, Expanded, Merlin and Kibra, play a critical role in promoting Hpo dimerization as well as association to the cortical F-actin ..
  12. Edgar B. From cell structure to transcription: Hippo forges a new path. Cell. 2006;124:267-73 pubmed
    ..The cytoskeletal proteins Merlin and Expanded, which play a role in cell adhesion and structure, control the activation of the Hippo/Salvador ..
  13. Karpowicz P, Perez J, Perrimon N. The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development. 2010;137:4135-45 pubmed publisher
    ..These findings demonstrate a cell-autonomous role for the Hippo pathway in SCs, and have implications for understanding the role of this pathway in tumorigenesis and cancer stem cells. ..
  14. Golovnina K, Blinov A, Akhmametyeva E, Omelyanchuk L, Chang L. Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene. BMC Evol Biol. 2005;5:69 pubmed
    b>Merlin, the product of the Neurofibromatosis type 2 (NF2) tumor suppressor gene, belongs to the ezrin-radixin-moesin (ERM) subgroup of the protein 4.1 superfamily, which links cell surface glycoproteins to the actin cytoskeleton...
  15. Genevet A, Wehr M, Brain R, Thompson B, Tapon N. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell. 2010;18:300-8 pubmed publisher
    ..The FERM domain proteins Merlin (Mer) and Expanded (Ex) represent one mode of upstream regulation controlling pathway activity...
  16. Yu J, Zheng Y, Dong J, Klusza S, Deng W, Pan D. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell. 2010;18:288-99 pubmed publisher
    ..The FERM domain proteins Merlin (Mer) and Expanded (Ex) are upstream components that regulate Hpo activity through unknown mechanisms...
  17. Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol. 2006;16:2081-9 pubmed
    ..The cytoskeletal proteins Merlin and Expanded colocalize at apical junctions and function redundantly upstream of Hippo...
  18. Sansores Garcia L, Bossuyt W, Wada K, Yonemura S, Tao C, Sasaki H, et al. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J. 2011;30:2325-35 pubmed publisher
    ..Thus, regulators of F-actin, and in particular Capping proteins, are essential for proper growth control by affecting Hippo signalling. ..
  19. Fernández B, Gaspar P, Bras Pereira C, Jezowska B, Rebelo S, Janody F. Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development. 2011;138:2337-46 pubmed publisher
    ..Taken together, these findings indicate a novel interplay between Hippo pathway activity and actin filament dynamics that is essential for normal growth control. ..
  20. Hughes S, Fehon R. Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase. J Cell Biol. 2006;175:305-13 pubmed
    b>Merlin and Moesin are closely related members of the 4.1 Ezrin/Radixin/Moesin domain superfamily implicated in regulating proliferation and epithelial integrity, respectively...
  21. Maitra S, Kulikauskas R, Gavilan H, Fehon R. The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr Biol. 2006;16:702-9 pubmed
    ..Here we examine the mechanism by which the Drosophila Neurofibromatosis 2 (NF2) tumor suppressor ortholog Merlin (Mer) and the related tumor suppressor expanded (ex) regulate proliferation and differentiation in imaginal ..
  22. McCartney B, Kulikauskas R, LaJeunesse D, Fehon R. The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. Development. 2000;127:1315-24 pubmed
    ..The Neurofibromatosis-2 tumor suppressor gene encodes Merlin, a member of the Protein 4.1 superfamily most closely related to Ezrin, Radixin and Moesin...
  23. Willecke M, Hamaratoglu F, Kango Singh M, Udan R, Chen C, Tao C, et al. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol. 2006;16:2090-100 pubmed
    The Hippo tumor-suppressor pathway has emerged as a key signaling pathway that controls tissue size in Drosophila. Merlin, the Drosophila homolog of the human Neurofibromatosis type-2 (NF2) tumor-suppressor gene, and the related protein ..
  24. Hariharan I. Growth regulation: a beginning for the hippo pathway. Curr Biol. 2006;16:R1037-9 pubmed
    ..A signaling pathway involving two protein kinases, Hippo and Warts, restricts the growth of imaginal discs in Drosophila. Four recent studies taken together show that the protocadherin Fat can regulate Warts in two different ways. ..
  25. Robinson B, Huang J, Hong Y, Moberg K. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol. 2010;20:582-90 pubmed publisher
  26. Poon C, Lin J, Zhang X, Harvey K. The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell. 2011;21:896-906 pubmed publisher
    ..Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes. ..
  27. Yu J, Poulton J, Huang Y, Deng W. The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity. PLoS ONE. 2008;3:e1761 pubmed publisher
  28. Sun S, Reddy B, Irvine K. Localization of Hippo signalling complexes and Warts activation in vivo. Nat Commun. 2015;6:8402 pubmed publisher
    ..Our observations define spatial relationships among Hippo signalling components and establish the functional importance of their localization to Warts activation. ..
  29. Iudina O, Golovnina K, Dorogova N, Kopyl S, Bolobolova E, Dubatolova T, et al. [The role of the functional sites of the Merlin tumor suppressor in Drosophila spermatogenesis]. Genetika. 2010;46:1376-8 pubmed
    The Merlin gene of Drosophila is homologous to the human Neurofibromatosis 2 (NF2) gene an important regulator of proliferation and endocytosis of cell receptors...
  30. Fehon R, Lajeunesse D, Lamb R, McCartney B, Schweizer L, Ward R. Functional studies of the protein 4.1 family of junctional proteins in Drosophila. Soc Gen Physiol Ser. 1997;52:149-59 pubmed
  31. Thomson T, Schneemann A, Johnson J. Oocyte destruction is activated during viral infection. Genesis. 2012;50:453-65 pubmed publisher
    ..As seen with in vivo TOR inhibition, oogenesis was partially rescued in loss of function discs large and merlin mutants...
  32. Panneton V, Nath A, Sader F, Delaunay N, Pelletier A, Maier D, et al. Regulation of Catalytic and Non-catalytic Functions of the Drosophila Ste20 Kinase Slik by Activation Segment Phosphorylation. J Biol Chem. 2015;290:20960-71 pubmed publisher
  33. Jahanshahi M, Hsiao K, Jenny A, Pfleger C. The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts. PLoS Genet. 2016;12:e1006198 pubmed publisher
    ..of the core kinases Hippo and Warts and plays a post-transcriptional role to increase the protein levels of the Merlin, Hippo, and Warts components of the pathway; therefore, in addition to Rae1 coordinating organ size regulation ..
  34. Pertceva J, Dorogova N, Bolobolova E, Nerusheva O, Fedorova S, Omelyanchuk L. The role of Drosophila hyperplastic discs gene in spermatogenesis. Cell Biol Int. 2010;34:991-6 pubmed publisher
    ..1994) Dev Biol 165, 507-526]. Earlier, we demonstrated that the Drosophila tumour suppressor Merlin participates not only in imaginal discs proliferation control, but also performs a separate Nebenkern structural ..
  35. Reddy B, Irvine K. Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. Development. 2011;138:5201-12 pubmed publisher
    ..Yorkie activity in glial cells is controlled by a Merlin-Hippo signaling pathway, whereas the upstream Hippo pathway regulators Fat, Expanded, Crumbs and Lethal giant ..
  36. Omelyanchuk L, Pertseva J, Saul J. Evolutionary origin of the tumor suppressor hyperplastic discs protein. In Silico Biol. 2009;9:203-7 pubmed
    Previous evolutionary study of the tumor suppressor Merlin revealed that this protein family was produced by very early metazoans with the exception of some or all flatworm lineages [Golovnina et al., 2005]...
  37. BARRON D, Kagey J. The role of the Hippo pathway in human disease and tumorigenesis. Clin Transl Med. 2014;3:25 pubmed publisher
    ..The common activation of YAP in many different tumor types provides an attractive target for potential therapeutic intervention. ..
  38. Hoover K, Bryant P. Drosophila Yurt is a new protein-4.1-like protein required for epithelial morphogenesis. Dev Genes Evol. 2002;212:230-8 pubmed
    ..A mammalian homolog of Yurt is up-regulated in metastatic melanoma cells. These novel cytoskeletal proteins appear to play important roles in epithelial cell movements and in the morphogenetic tissue changes that depend on them. ..
  39. Huang H, Wang S, Yin M, Dong L, Wang C, Wu W, et al. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS Biol. 2013;11:e1001620 pubmed publisher
    ..Furthermore, we provided evidence that Par-1-induced Hpo regulation is conserved in mammalian cells. Taken together, our findings identified Par-1 as a novel component of the Hpo signaling network. ..
  40. Milton C, Grusche F, Degoutin J, Yu E, Dai Q, Lai E, et al. The Hippo pathway regulates hematopoiesis in Drosophila melanogaster. Curr Biol. 2014;24:2673-80 pubmed publisher
    ..Further, Yorkie or Scalloped hyperactivation induced ectopic crystal cells in a non-cell-autonomous and Notch-pathway-dependent fashion. ..
  41. Ding R, Weynans K, Bossing T, Barros C, Berger C. The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells. Nat Commun. 2016;7:10510 pubmed publisher
    ..Loss of crumbs or echinoid in the niche only is sufficient to reactivate NSCs. Finally, we provide evidence that the Hippo pathway activity discriminates quiescent from non-quiescent NSCs in the Drosophila nervous system. ..
  42. Vaqué J, Dorsam R, Feng X, Iglesias Bartolomé R, Forsthoefel D, Chen Q, et al. A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Mol Cell. 2013;49:94-108 pubmed publisher
  43. Kwon H, Waghmare I, Verghese S, Singh A, Singh A, Kango Singh M. Drosophila C-terminal Src kinase regulates growth via the Hippo signaling pathway. Dev Biol. 2015;397:67-76 pubmed publisher
    ..Furthermore, dCsk requires Yki for its growth regulatory functions, suggesting that dCsk is another upstream member of the network of genes that interact to regulate Wts and its effector Yki in the Hippo signaling pathway. ..
  44. Yang Y, Primrose D, Leung A, Fitzsimmons R, McDermand M, Missellbrook A, et al. The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila. Dev Biol. 2012;361:412-26 pubmed publisher
    The signalling activities of Merlin and Moesin, two closely related members of the protein 4.1 Ezrin/Radixin/Moesin family, are regulated by conformational changes. These changes are regulated in turn by phosphorylation...
  45. Jukam D, Desplan C. Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate. Dev Cell. 2011;21:874-87 pubmed publisher
    ..Here, we show that a subset of the Hippo pathway-Merlin, Kibra, and Lethal(2)giant larvae (Lgl), but not Expanded or Fat-is required for Warts expression and activity in ..
  46. Jukam D, Xie B, Rister J, TERRELL D, Charlton Perkins M, Pistillo D, et al. Opposite feedbacks in the Hippo pathway for growth control and neural fate. Science. 2013;342:1238016 pubmed publisher
    ..Altering feedback architecture provides an efficient mechanism to co-opt conserved signaling networks for diverse purposes in development and evolution. ..
  47. Sun S, Zhao S, Wang Z. Genes of Hippo signaling network act unconventionally in the control of germline proliferation in Drosophila. Dev Dyn. 2008;237:270-5 pubmed
    ..It appears that expanded acts from the somatic support cells surrounding the germline to restrict spermatogonial amplification. ..
  48. Hariharan I. Organ Size Control: Lessons from Drosophila. Dev Cell. 2015;34:255-65 pubmed publisher
    ..Mechanical forces also appear to have an important role along with the Hippo pathway, which may integrate multiple types of inputs to regulate the extent of growth. ..
  49. Huang J, Kalderon D. Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation. J Cell Biol. 2014;205:325-38 pubmed publisher
    ..These causal connections provide the most rigorous evidence to date that a niche signal can promote stem cell maintenance principally by stimulating stem cell proliferation. ..
  50. Yue T, Tian A, Jiang J. The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Dev Cell. 2012;22:255-67 pubmed publisher
    ..Overexpression of Sav or dimerized Ed cytoplasmic domain suppressed loss-of-Ed phenotypes. We propose that Ed may link cell-cell contact to Hpo signaling through binding and stabilizing Sav, thus modulating the Hpo kinase activity. ..
  51. Acharya P, Negre N, Johnston J, Wei Y, White K, Henry R, et al. Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein. G3 (Bethesda). 2012;2:1459-72 pubmed publisher
    ..Many of these targeted genes are bound by Rbf1 homologs in human cells, indicating that a conserved role of RB proteins may be to adjust the set point of interlinked signaling networks essential for growth and development. ..
  52. Dubatolova T, Dorogova N, Omel ianchuk L, Chang L. [Duration of the cell cycle phases in mutants for the tumor suppressor Merlin in Drosophila melanogaster]. Genetika. 2011;47:460-5 pubmed
    The cell cycle duration was estimated in Drosophila melanogaster mutants for the tumor suppressor Merlin with the use of different approaches...
  53. Fletcher G, Elbediwy A, Khanal I, Ribeiro P, Tapon N, Thompson B. The Spectrin cytoskeleton regulates the Hippo signalling pathway. EMBO J. 2015;34:940-54 pubmed publisher
    ..Our findings identify both apical and basolateral Spectrins as regulators of Hippo signalling and suggest Spectrins as potential mechanosensors. ..
  54. Bolobolova E, Iudina O, Dorogova N. [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia. 2011;53:31-8 pubmed
    Drosophila Merlin, an ortholog of the merlin protein encoded by the human Neurofibromatosis 2 (NF2) gene, is important for the regulation of cell proliferation and differentiation in the eye and wing...
  55. Lebedeva L, Akhmamet eva E, Omel ianchuk L. [Dynamics of the spatial organization of the chromosome set in cells of Drosophila melanogaster imaginal disks normally and under the action of the tumor-inducing mutation Merlin]. Genetika. 2010;46:180-6 pubmed
    ..In addition, a subpopulation of cells with an abnormally large volume of nuclear DNA during the G1 period was revealed in Mer4 larvae. The cells of this subpopulation do not enter into the DNA synthesis and quit the cycle. ..
  56. Benseñor L, Barlan K, Rice S, Fehon R, Gelfand V. Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Proc Natl Acad Sci U S A. 2010;107:7311-6 pubmed publisher
    The neurofibromatosis type 2 (NF2) tumor-suppressor protein Merlin is a member of the ERM family of proteins that links the cytoskeleton to the plasma membrane...
  57. Yan Y, Denef N, Tang C, Schupbach T. Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling. Development. 2011;138:1697-703 pubmed publisher
    ..PI4KIIIalpha mutations also cause misexpression of well-established Hippo signaling targets. The Merlin-Expanded-Kibra complex is required at the apical membrane for Hippo activity...
  58. Ilanges A, Jahanshahi M, Balobin D, Pfleger C. Alcohol interacts with genetic alteration of the Hippo tumor suppressor pathway to modulate tissue growth in Drosophila. PLoS ONE. 2013;8:e78880 pubmed publisher
    ..We propose that exceeding certain thresholds of alcohol exposure activates Hippo signaling to maintain proper growth control and prevent alcohol-mediated mis-patterning and tissue overgrowth. ..
  59. Milton C, Zhang X, Albanese N, Harvey K. Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster. Development. 2010;137:735-43 pubmed publisher
    ..activity in the pupal eye, but loss of fat or expanded at this stage of development can be compensated for by Merlin. Fat appears to repress Yorkie independently of Dachs in the pupal eye, which would contrast with the mode of ..
  60. Iudina O, Gusachenko A, Akhmamet eva E, Omel ianchuk L. [Chromosome nondisjunction in Drosophila strains mutant for tumor suppressor Merlin]. Genetika. 2008;44:414-6 pubmed
    The effect of mutation for gene Merlin on chromosome disjunction in Drosophila during meiosis was genetically studied...
  61. Pirraglia C, Walters J, Myat M. Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape. Development. 2010;137:4177-89 pubmed publisher
    ..We also demonstrate that Cdc42 and Merlin act together with Pak1 to control lumen size...
  62. Li W, Baker N. The active role of corpse engulfment pathways during cell competition. Fly (Austin). 2007;1:274-8 pubmed
    ..We also speculate about how cell interactions at clone boundaries may initiate cell competition. ..
  63. Salah Z, Aqeilan R. WW domain interactions regulate the Hippo tumor suppressor pathway. Cell Death Dis. 2011;2:e172 pubmed publisher
    ..We further discuss new insights and future directions on the emerging role of such regulation. ..
  64. Su T, Ludwig M, Xu J, Fehon R. Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded. Dev Cell. 2017;40:478-490.e3 pubmed publisher
    ..Three membrane-associated proteins, Kibra, Merlin, and Expanded, regulate pathway activity, but the precise molecular mechanism by which they function is still ..