Mdr65

Summary

Gene Symbol: Mdr65
Description: Multiple drug resistance 65
Alias: CG10181, Dmel\CG10181, MDR65, Mdr65A, mdr65, CG10181-PA, Mdr65-PA, P-glycoprotein65-Dm, multiple drug resistance 65
Species: fruit fly

Top Publications

  1. ncbi Isolation and characterization of Drosophila multidrug resistance gene homologs
    C T Wu
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Mol Cell Biol 11:3940-8. 1991
  2. ncbi Analysis of Mdr50: a Drosophila P-glycoprotein/multidrug resistance gene homolog
    B Gerrard
    Biological Carcinogenesis and Development Program, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702 1201
    Genomics 17:83-8. 1993
  3. ncbi Identification of P-glycoprotein/multidrug resistance genes from model organisms
    R Allikmets
    Laboratory of Viral Carcinogenesis, Program Resources Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702
    Leukemia 7:S13-7. 1993
  4. ncbi A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system
    I Nasonkin
    Department of Pediatric, University of Michigan, Ann Arbor, Michigan 48109 0646, USA
    J Biol Chem 274:29420-5. 1999
  5. ncbi Genetics of alpha-amanitin resistance in a natural population of Drosophila melanogaster
    D J Begun
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Patterson Labs, C0930, Austin, TX 78712, USA
    Heredity (Edinb) 85:184-90. 2000
  6. ncbi Expression of mdr49 and mdr65 multidrug resistance genes in larval tissues of Drosophila melanogaster under normal and stress conditions
    Madhu G Tapadia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Cell Stress Chaperones 10:7-11. 2005
  7. ncbi An ABC transporter controls export of a Drosophila germ cell attractant
    Sara Ricardo
    Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York University, 540 First Avenue, New York, NY 10016, USA
    Science 323:943-6. 2009
  8. ncbi Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila
    Fahima Mayer
    Department of Anesthesia and Perioperative Care, San Francisco General Hospital, and Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 29:3538-50. 2009
  9. ncbi Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster
    Sarah Chahine
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Insect Physiol 55:927-35. 2009

Scientific Experts

  • D J Begun
  • Fahima Mayer
  • Sarah Chahine
  • Sara Ricardo
  • Madhu G Tapadia
  • Deanna Kroetz
  • Michael J O'Donnell
  • Robert L Pinsonneault
  • Leslie Chinn
  • Nasima Mayer
  • Ruth Lehmann
  • Roland J Bainton
  • I Nasonkin
  • S C Lakhotia
  • M Egan
  • B Gerrard
  • P M Thomas
  • C Ambrose
  • A Alikasifoglu
  • A Sarniak
  • M Cheng
  • P Cahill
  • R Allikmets
  • M Dean
  • C Stewart
  • M White
  • C T Wu
  • J M Croop
  • M S Griffin
  • M Budding

Detail Information

Publications9

  1. ncbi Isolation and characterization of Drosophila multidrug resistance gene homologs
    C T Wu
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Mol Cell Biol 11:3940-8. 1991
    ..This work sets the foundation for the molecular and genetic analysis of mdr homologs in Drosophila melanogaster...
  2. ncbi Analysis of Mdr50: a Drosophila P-glycoprotein/multidrug resistance gene homolog
    B Gerrard
    Biological Carcinogenesis and Development Program, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702 1201
    Genomics 17:83-8. 1993
    ..Mdr50 represents the third MDR homolog identified in Drosophila. Conservation in the position of intervening sequences between Mdr50 and the human MDR genes provides further evidence for their common origin...
  3. ncbi Identification of P-glycoprotein/multidrug resistance genes from model organisms
    R Allikmets
    Laboratory of Viral Carcinogenesis, Program Resources Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702
    Leukemia 7:S13-7. 1993
    ..While the function of these sequences has not been determined, they may prove to be useful for developing a model to study the function of P-glycoproteins...
  4. ncbi A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system
    I Nasonkin
    Department of Pediatric, University of Michigan, Ann Arbor, Michigan 48109 0646, USA
    J Biol Chem 274:29420-5. 1999
    ..The lack of gene duplication in the Drosophila system provides a unique opportunity for functional studies of SUR using a genetic approach...
  5. ncbi Genetics of alpha-amanitin resistance in a natural population of Drosophila melanogaster
    D J Begun
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Patterson Labs, C0930, Austin, TX 78712, USA
    Heredity (Edinb) 85:184-90. 2000
    ..crosses of chromosome III support a role for a naturally occurring polymorphism in a multidrug resistance gene (Mdr65A) in alpha-amanitin resistance...
  6. ncbi Expression of mdr49 and mdr65 multidrug resistance genes in larval tissues of Drosophila melanogaster under normal and stress conditions
    Madhu G Tapadia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Cell Stress Chaperones 10:7-11. 2005
    In situ expression of 2 multidrug resistance genes, mdr49 and mdr65, of Drosophila melanogaster was examined in wild-type third instar larval tissues under physiological conditions and after heat shock or colchicine feeding...
  7. ncbi An ABC transporter controls export of a Drosophila germ cell attractant
    Sara Ricardo
    Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York University, 540 First Avenue, New York, NY 10016, USA
    Science 323:943-6. 2009
    ..Components of this unconventional export pathway are highly conserved, suggesting that this pathway may control the production of similarly modified chemoattractants in organisms ranging from yeast to humans...
  8. ncbi Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila
    Fahima Mayer
    Department of Anesthesia and Perioperative Care, San Francisco General Hospital, and Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 29:3538-50. 2009
    ..We characterize a fly ATP binding cassette (ABC) transporter, Mdr65, that functions similarly to mammalian xenobiotic BBB transporters and show that varying its levels solely in the ..
  9. ncbi Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster
    Sarah Chahine
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Insect Physiol 55:927-35. 2009
    ..Increased levels of the protein products which may result from expression of these genes may enhance elimination of toxic compounds such as MTX or its metabolites...