Gene Symbol: Mcr
Description: Macroglobulin complement-related
Alias: CG7586, DmTEP6, Dmel\CG7586, E(br)155, TEP6, TEP6mel, Tep6, TepVI, alpha-2-Mrp, anon-28DE, dTEPVI, luf, mcr, macroglobulin complement-related, CG7586-PA, E(br)155, Mcr-PA, TEP, Tep6, alpha-2-macroglobulin related, enhancer of broad, enhancer of broad 155, luftschlange, macroglobulin complement related, thiolester containing protein VI
Species: fruit fly

Top Publications

  1. Ward R, Evans J, Thummel C. Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis. Genetics. 2003;165:1397-415 pubmed
  2. Erturk Hasdemir D, Silverman N. Eater: a big bite into phagocytosis. Cell. 2005;123:190-2 pubmed
    ..In this issue of Cell, Kocks et al. (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila. ..
  3. Stabell M, Bjørkmo M, Aalen R, Lambertsson A. The Drosophila SET domain encoding gene dEset is essential for proper development. Hereditas. 2006;143:177-88 pubmed
    ..The spatio-temporal expression profiles of dEset and its potential partners suggest that they may act together or even in a larger complex. ..
  4. Sharifkhodaei Z, Padash Barmchi M, Gilbert M, Samarasekera G, Fulga T, Van Vactor D, et al. The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184. J Cell Sci. 2016;129:1477-89 pubmed publisher
    ..miR-184 also targets a suite of septate junction proteins, including NrxIV, coracle and Mcr. miR-184 expression is triggered when Gliotactin is overexpressed, leading to activation of the BMP signalling ..
  5. Hall S, Bone C, Oshima K, Zhang L, McGraw M, Lucas B, et al. Macroglobulin complement-related encodes a protein required for septate junction organization and paracellular barrier function in Drosophila. Development. 2014;141:889-98 pubmed publisher
    ..Here we demonstrate that Macroglobulin complement-related (Mcr), a gene previously implicated in innate immunity, plays an essential role during embryonic development in SJ ..
  6. Bätz T, Förster D, Luschnig S. The transmembrane protein Macroglobulin complement-related is essential for septate junction formation and epithelial barrier function in Drosophila. Development. 2014;141:899-908 pubmed publisher
    ..Here we report the identification of Macroglobulin complement-related (Mcr), a member of the conserved ?-2-macroglobulin (?2M) complement protein family, as a novel SJ-associated protein in ..
  7. Byri S, Misra T, Syed Z, Bätz T, Shah J, Boril L, et al. The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila. Dev Cell. 2015;33:535-48 pubmed publisher
    ..Conversely, Aka's cytoplasmic tail is dispensable for TCJ localization. Thus, extracellular interactions, rather than TCJ-directed intracellular transport, appear to mediate TCJ assembly. ..
  8. Vallejo C, Leon P. Diadenosine 5",5"'P1,P4-tetraphosphatase in Drosophila embryos: developmental regulation and characterization. Int J Biochem. 1989;21:1223-8 pubmed
    ..5 hr later. 9. From this time to 3.5 hr the activity decreased to remain at a plateau until the end of embryogenesis. 10. The profile of activity is compatible with its involvement in the regulation of nuclear division. ..
  9. Crowley T, Hoey T, Liu J, Jan Y, Jan L, Tjian R. A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila. Nature. 1993;361:557-61 pubmed
    ..Our results suggest that TBP-related factor is a sequence-specific transcription factor that shares the DNA-binding properties of TBP. ..

More Information


  1. Zhang L, Ward R. uninflatable encodes a novel ectodermal apical surface protein required for tracheal inflation in Drosophila. Dev Biol. 2009;336:201-12 pubmed publisher
    ..Tracheal tubes in mutant larvae are often crushed or twisted, although tracheal patterning and maturation appear normal during embryogenesis. uif mutant larvae also show defects in tracheal growth and molting of their tracheal cuticle. ..
  2. Bou Aoun R, Hetru C, Troxler L, Doucet D, Ferrandon D, Matt N. Analysis of thioester-containing proteins during the innate immune response of Drosophila melanogaster. J Innate Immun. 2011;3:52-64 pubmed publisher
    ..In Drosophila, the Tep family is composed of 6 genes named Tep1-Tep6. In this study, we investigated the phylogeny, expression pattern and roles of these genes in the host defense of ..
  3. Hamilos G, Samonis G, Kontoyiannis D. Recent Advances in the Use of Drosophila melanogaster as a Model to Study Immunopathogenesis of Medically Important Filamentous Fungi. Int J Microbiol. 2012;2012:583792 pubmed publisher
    ..In view of recent advances in Drosophila genetics, fruit flies will become an invaluable surrogate model to study immunopathogenesis of fungal diseases. ..