Gene Symbol: Mcm10
Description: Minichromosome maintenance 10
Alias: CG9241, DmMCM10, Dmel\CG9241, Scim19, dMcm10, mcm10, minichromosome maintenance 10, CG9241-PA, Mcm10-PA, sensitized chromosome inheritance modifier 19
Species: fruit fly

Top Publications

  1. Christensen T, Tye B. Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation. Mol Biol Cell. 2003;14:2206-15 pubmed
    b>Mcm10 is required for the initiation of DNA replication in Saccharomyces cerevisiae. We have cloned MCM10 from Drosophila melanogaster and show that it complements a ScMCM10 null mutant...
  2. Apger J, Reubens M, Henderson L, Gouge C, Ilic N, Zhou H, et al. Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles. Genetics. 2010;185:1151-65 pubmed publisher
    ..We present an analysis of two Drosophila mutants in the conserved DNA replication protein Mcm10. A hypomorphic mutant demonstrates that Mcm10 has a role in heterochromatic silencing and chromosome condensation, ..
  3. Dobie K, Kennedy C, Velasco V, McGrath T, Weko J, Patterson R, et al. Identification of chromosome inheritance modifiers in Drosophila melanogaster. Genetics. 2001;157:1623-37 pubmed
  4. Gouge C, Christensen T. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity. Biochem Biophys Res Commun. 2010;400:145-50 pubmed publisher
    ..We show that Drosophila Sld5 interacts with Psf1, Psf2, and Mcm10 and that mutations in Sld5 lead to M and S phase delays with chromosomes exhibiting hallmarks of genomic ..
  5. Gallone G, Simpson T, Armstrong J, Jarman A. Bio::Homology::InterologWalk--a Perl module to build putative protein-protein interaction networks through interolog mapping. BMC Bioinformatics. 2011;12:289 pubmed publisher
    ..The Bio::Homology::InterologWalk module, sample scripts and full documentation are freely available from the Comprehensive Perl Archive Network (CPAN) under the GNU Public license. ..
  6. Vo N, Taga A, Inaba Y, Yoshida H, Cotterill S, Yamaguchi M. Drosophila Mcm10 is required for DNA replication and differentiation in the compound eye. PLoS ONE. 2014;9:e93450 pubmed publisher
    ..Knockdown of Drosophila Mcm10 (dMcm10) by RNA interference in eye imaginal discs induces abnormal eye morphology (rough eye phenotype), and the number ..
  7. Reubens M, Biller M, Bedsole S, Hopkins L, Ables E, Christensen T. Mcm10 is required for oogenesis and early embryogenesis in Drosophila. Mech Dev. 2015;138 Pt 3:291-9 pubmed publisher
    ..It is well documented that Mcm10 is intimately linked to both of these important biological processes; therefore, it is not surprising that Mcm10 ..
  8. Abramov Y, Shatskikh A, Maksimenko O, Bonaccorsi S, Gvozdev V, Lavrov S. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila. Genetics. 2016;202:93-106 pubmed publisher
    ..We demonstrate that trans-inactivation is followed by de novo HP1a accumulation in the affected transgene; trans-inactivation is specifically favored by the chromatin remodeler SAYP and prevented by Argonaute AGO2. ..
  9. Vo N, Anh Suong D, Yoshino N, Yoshida H, Cotterill S, Yamaguchi M. Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation. Nucleic Acids Res. 2017;45:1233-1254 pubmed publisher
    Both Mcm10 and HP1a are known to be required for DNA replication. However, underlying mechanism is not clarified yet especially for HP1...

More Information


  1. Long H, Cameron S, Yu L, Rao Y. De novo GMP synthesis is required for axon guidance in Drosophila. Genetics. 2006;172:1633-42 pubmed
    ..Our study thus provides the first in vivo evidence to support an essential and specific role for de novo synthesis of guanine nucleotides in axon guidance. ..
  2. Suyari O, Kawai M, Ida H, Yoshida H, Sakaguchi K, Yamaguchi M. Differential requirement for the N-terminal catalytic domain of the DNA polymerase ? p255 subunit in the mitotic cell cycle and the endocycle. Gene. 2012;495:104-14 pubmed publisher
    ..In addition, several genetic interactants with dpol?p255 including genes related to DNA replication such as RFC, DNA primase, DNA pol?, Mcm10 and Psf2 and chromatin remodeling such as Iswi were also identified.