mats

Summary

Gene Symbol: mats
Description: mob as tumor suppressor
Alias: CG13852, DMob1, Dmel\CG13852, Dmob1, Mats, Mob1, anon-WO0118547.303, dmob1, CG13852 gene product from transcript CG13852-RB, CG13852-PA, CG13852-PB, CG13852-PC, Mob as tumor suppresso, Mob as tumor suppressor, mats-PA, mats-PB, mats-PC
Species: fruit fly

Top Publications

  1. pmc The Drosophila RASSF homolog antagonizes the hippo pathway
    Cedric Polesello
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Institute, 44 Lincoln s Inn Fields, London, United Kingdom
    Curr Biol 16:2459-65. 2006
  2. doi The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway
    Carole L C Poon
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    Dev Cell 21:896-906. 2011
  3. doi Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila
    Li Lun Ho
    Intercollege Graduate Degree Program in Cell and Developmental Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Dev Biol 337:274-83. 2010
  4. pmc Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms
    Fangfang Ren
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Biol 337:303-12. 2010
  5. ncbi Control of cell proliferation and apoptosis by mob as tumor suppressor, mats
    Zhi Chun Lai
    Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Cell 120:675-85. 2005
  6. pmc In vivo regulation of Yorkie phosphorylation and localization
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 135:1081-8. 2008
  7. doi Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila
    Beatriz García Fernández
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, P 2780 156 Oeiras, Portugal
    Development 138:2337-46. 2011
  8. pmc Zyxin links fat signaling to the hippo pathway
    Cordelia Rauskolb
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Biol 9:e1000624. 2011
  9. ncbi Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch
    Cedric Polesello
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2 3PX, United Kingdom
    Curr Biol 17:1864-70. 2007
  10. pmc Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila
    Xiaomu Wei
    Intercollege Graduate Program in Genetics, The Pennsylvania State University, University Park, PA 16802, USA
    EMBO J 26:1772-81. 2007

Research Grants

  1. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
  2. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007

Scientific Experts

  • Patrick Laprise
  • Z C Lai
  • BRUCE EDGAR
  • Cedric Polesello
  • Nicolas Tapon
  • Shuguo Sun
  • Kenneth D Irvine
  • Bo Liu
  • Yonggang Zheng
  • Li Lun Ho
  • Takeshi Shimizu
  • Lei Zhang
  • Jin Jiang
  • Cordelia Rauskolb
  • Hyangyee Oh
  • Xiaolan Fang
  • Xiaomu Wei
  • Duojia Pan
  • Alina M Vrabioiu
  • Lin Zhang
  • DANIEL A BARRON
  • Renée M Robbins
  • Michael C Wehr
  • Yifan Zhang
  • B V V G Reddy
  • Eliana P Lucas
  • Hong Ling Huang
  • Yun Zhao
  • Yi Lu
  • Zhaocai Zhou
  • Liang Dong
  • Yunyun Jin
  • Xin Ye
  • Francesca Fausti
  • Pedro Gaspar
  • Tianyi Zhang
  • David Jukam
  • Nuria Lopez-Bigas
  • Mary Truscott
  • Brandon N Nicolay
  • Maxim V Frolov
  • Carole L C Poon
  • Abul B M M K Islam
  • Beatriz García Fernández
  • Fangfang Ren
  • Joost Schulte
  • Yongfei Yang
  • Oren Schuldiner
  • Sudeshna Dutta
  • Paul N Adler
  • Laurent Menut
  • Iswar K Hariharan
  • Marcos Vidal
  • Eunjoo Cho
  • Julien Colombani
  • Ying He
  • Joseph M Bateman
  • Feng Yin
  • Neal Silverman
  • Jianzhong Yu
  • Hua Deng
  • Gary Struhl
  • Wei Wang
  • Eliza Uster
  • Shuping Yang
  • Greg J Beitel
  • Joachim Kremerskothen
  • Yuanhong Chen
  • Jixin Dong
  • Samantha C Gbur
  • Dirk Oliver Wennmann
  • Jacob D Kagey
  • Chuanyang Dai
  • Michael Howell
  • Wei Wu
  • Georgina C Fletcher
  • Moritz J Rossner
  • Tobias M Maile
  • Maxine V Holder
  • Rachael Instrell
  • Hongbin Ji
  • Bin Zhao
  • Elena Ciirdaeva
  • Ieva Gailite
  • Barry J Thompson
  • Rebecca E Saunders
  • Ming Jiang
  • Chao Wang
  • Shimin Wang
  • Xiaocan Guo

Detail Information

Publications44

  1. pmc The Drosophila RASSF homolog antagonizes the hippo pathway
    Cedric Polesello
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Institute, 44 Lincoln s Inn Fields, London, United Kingdom
    Curr Biol 16:2459-65. 2006
    ..Ex) and Merlin (Mer), two serine/threonine kinases, Hpo and Warts (Wts), the scaffold proteins Salvador (Sav) and Mats, and the transcriptional coactivator Yorkie (Yki)...
  2. doi The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway
    Carole L C Poon
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    Dev Cell 21:896-906. 2011
    ..Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes...
  3. doi Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila
    Li Lun Ho
    Intercollege Graduate Degree Program in Cell and Developmental Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Dev Biol 337:274-83. 2010
    ..However, the cellular mechanism by which the core components like Mob as tumor suppressor (Mats) and Warts (Wts) protein kinase are activated is poorly understood...
  4. pmc Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms
    Fangfang Ren
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Biol 337:303-12. 2010
    ..Finally, we provided evidence that Hpo signaling restricted Yki nuclear localization depending on CRM1-mediated nuclear export...
  5. ncbi Control of cell proliferation and apoptosis by mob as tumor suppressor, mats
    Zhi Chun Lai
    Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Cell 120:675-85. 2005
    ..Here we describe growth inhibitory functions for a Mob superfamily protein, termed Mats (Mob as tumor suppressor), in Drosophila...
  6. pmc In vivo regulation of Yorkie phosphorylation and localization
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 135:1081-8. 2008
    ..These results identify modulation of subcellular localization as a mechanism of Yki regulation, and establish that this regulation occurs in vivo through multiple sites of Warts-dependent phosphorylation on Yki...
  7. doi Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila
    Beatriz García Fernández
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, P 2780 156 Oeiras, Portugal
    Development 138:2337-46. 2011
    ..Taken together, these findings indicate a novel interplay between Hippo pathway activity and actin filament dynamics that is essential for normal growth control...
  8. pmc Zyxin links fat signaling to the hippo pathway
    Cordelia Rauskolb
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Biol 9:e1000624. 2011
    ..Our identification of Zyx as a regulator of Hippo signaling thus also raises the possibility that mechanical strain could be linked to the regulation of gene expression and growth through Hippo signaling...
  9. ncbi Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch
    Cedric Polesello
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2 3PX, United Kingdom
    Curr Biol 17:1864-70. 2007
    ..is composed of two serine/threonine kinases Hippo (Hpo) and Warts (Wts), the scaffold proteins Salvador (Sav) and Mats, and the transcriptional coactivator Yorkie (Yki) [1]. Two band 4...
  10. pmc Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila
    Xiaomu Wei
    Intercollege Graduate Program in Genetics, The Pennsylvania State University, University Park, PA 16802, USA
    EMBO J 26:1772-81. 2007
    ..Here we provide evidence that the Mob as tumor suppressor protein, Mats, functions as a key component of the Hpo signaling pathway...
  11. pmc Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control
    Yunyun Jin
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 287:5784-96. 2012
    ....
  12. ncbi Delineation of a Fat tumor suppressor pathway
    Eunjoo Cho
    Howard Hughes Medical Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Genet 38:1142-50. 2006
    ..The tumor suppressors Merlin, expanded, hippo, salvador and mob as tumor suppressor also share multiple Fat pathway phenotypes but regulate Warts activity independently...
  13. ncbi Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage
    Julien Colombani
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute
    Curr Biol 16:1453-8. 2006
    ..pathway comprises the kinases Hpo and Warts/Lats (Wts), the adaptors Salvador (Sav) and Mob1 as a tumor suppressor (Mats), the cytoskeletal proteins Expanded and Merlin, and the transcriptional cofactor Yorkie (Yki) ...
  14. ncbi From cell structure to transcription: Hippo forges a new path
    Bruce A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Cell 124:267-73. 2006
    ..and structure, control the activation of the Hippo/Salvador kinase complex, which in turn activates the Warts/Mats kinase complex...
  15. doi Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila
    Xin Ye
    Intercollege Graduate Degree Program in Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
    Dev Biol 369:115-23. 2012
    ..Thus, Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity...
  16. pmc Emerging role for epithelial polarity proteins of the Crumbs family as potential tumor suppressors
    Patrick Laprise
    Department of Molecular Biology, Medical Biochemistry and Pathology Cancer Research Center, Laval University and CRCHUQ Hôtel Dieu de Québec, 9 McMahon, Quebec, QC, Canada G1R 2J6
    J Biomed Biotechnol 2011:868217. 2011
    ..Thereby, these studies provide a molecular basis explaining how regulation of epithelial polarity is coupled to tumorogenesis...
  17. pmc Hippo and rassf1a Pathways: A Growing Affair
    Francesca Fausti
    Molecular Chemoprevention Group, Molecular Medicine Area, Regina Elena Cancer Institute, Via Elio Chianesi 53, 00143 Rome, Italy
    Mol Biol Int 2012:307628. 2012
    ..Recently, the impact of RASSF proteins on Hippo signaling potentiating its proapoptotic activity has been addressed, thus, providing further evidence for Hippo's key role in mammalian tumorigenesis as well as other important diseases...
  18. pmc Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila
    Michael C Wehr
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Nat Cell Biol 15:61-71. 2013
    ..core is a kinase cassette, comprising the kinases Hpo and Warts (Wts) and the scaffold proteins Salvador (Sav) and Mats, which inactivates the pro-growth transcriptional co-activator Yorkie (Yki)...
  19. pmc Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate
    David Jukam
    Center for Developmental Genetics, Department of Biology, New York University, 100 Washington Square East, New York, NY 10003 6688, USA
    Dev Cell 21:874-87. 2011
    ..These results reveal roles for Merlin, Kibra, and Lgl in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps...
  20. doi Mob as tumor suppressor is regulated by bantam microRNA through a feedback loop for tissue growth control
    Yifan Zhang
    Intercollege Graduate Degree Program in Genetics, The Pennsylvania State University, University Park, PA 16802, United States
    Biochem Biophys Res Commun 439:438-42. 2013
    ..In this report, we show that bantam microRNA functions to increase the level of the Mob as tumor suppressor protein Mats, a core component of the Hippo pathway, but does not regulate mats at the transcript level...
  21. pmc The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells
    Eliana P Lucas
    Epithelial Biology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3LY, England, UK
    J Cell Biol 201:875-85. 2013
    ..Instead, Warts phosphorylates and inhibits the actin regulator Ena to activate F-actin Capping protein activity on inner membranes and thereby restricts F-actin polymerization mainly to the outer rim of the migrating cluster...
  22. pmc Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association
    Hong Ling Huang
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P R China
    PLoS Biol 11:e1001620. 2013
    ..Furthermore, we provided evidence that Par-1-induced Hpo regulation is conserved in mammalian cells. Taken together, our findings identified Par-1 as a novel component of the Hpo signaling network. ..
  23. pmc KIBRA: In the brain and beyond
    Lin Zhang
    Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Cell Signal 26:1392-9. 2014
    ..At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond...
  24. pmc Non-canonical roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in epithelial tube size control
    Renée M Robbins
    Department of Molecular Biosciences and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 9:e101609. 2014
    ..Strikingly, there is no change in tracheal cell number in DIAP1 or Ice mutants, thus epithelial tube size regulation defines new non-apoptotic roles for Yki, DIAP1 and Ice. ..
  25. pmc The role of the Hippo pathway in human disease and tumorigenesis
    DANIEL A BARRON
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
    Clin Transl Med 3:25. 2014
    ..The common activation of YAP in many different tumor types provides an attractive target for potential therapeutic intervention. ..
  26. pmc Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade
    Yonggang Zheng
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 34:642-55. 2015
    ..These Hpo/Mst-like kinases provide an expanded view of the Hippo kinase cascade in development and physiology...
  27. pmc Localization of Hippo signalling complexes and Warts activation in vivo
    Shuguo Sun
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Nat Commun 6:8402. 2015
    ..Our observations define spatial relationships among Hippo signalling components and establish the functional importance of their localization to Warts activation. ..
  28. pmc Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase Warts
    Alina M Vrabioiu
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Cell 35:737-49. 2015
    ..on its transition from an inactive, "closed" conformation to a potentially active, "open" conformation mediated by Mats, a conserved Mps1-binder (Mob) protein...
  29. pmc Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila
    Bo Liu
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 164:406-19. 2016
    ....
  30. pmc Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit
    Brandon N Nicolay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 25:323-35. 2011
    ..We suggest that such functional interactions would influence Yki activity and help diversify the transcriptional output of the Hippo pathway...
  31. pmc mir-11 limits the proapoptotic function of its host gene, dE2f1
    Mary Truscott
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 25:1820-34. 2011
    ..Thus, our data support a model in which the coexpression of miR-11 limits the proapoptotic function of its host gene, dE2f1, upon DNA damage by directly modulating a dE2F1-dependent apoptotic transcriptional program...
  32. pmc Yki/YAP, Sd/TEAD and Hth/MEIS control tissue specification in the Drosophila eye disc epithelium
    Tianyi Zhang
    Department of Ophthalmology, Center for Vision Research, and SUNY Eye Institute, SUNY Upstate Medical University, Syracuse, New York, United States of America
    PLoS ONE 6:e22278. 2011
    ..Our results support a critical role for Yki- and its partners Sd and Hth--in shaping the fate map of the eye epithelium independently of its universal role as a regulator of proliferation and survival...
  33. pmc DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization
    Joost Schulte
    Department of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, The Picower Institute for Learning and Memory, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:5189-203. 2010
    ..Models for Mob function are primarily based on studies of Mob1 and Mob2 family members in yeast...
  34. pmc Regulation of cell shape, wing hair initiation and the actin cytoskeleton by Trc/Fry and Wts/Mats complexes
    Xiaolan Fang
    Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
    Dev Biol 341:360-74. 2010
    ..In addition, we showed that the effects on cell shape and the timing of differentiation appear to be not linked to changes in relative growth rate of cells compared to their neighbors...
  35. pmc Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila
    Sudeshna Dutta
    Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
    Curr Biol 18:1466-75. 2008
    ..Although the Warts (Wts) tumor suppressor is a critical regulator of tissue growth in animals, it is not clear how this signaling pathway controls cell growth...
  36. doi Both upstream and downstream intergenic regions are critical for the mob as tumor suppressor gene activity in Drosophila
    Yongfei Yang
    Center of Genetics and Developmental Biology, College of Life Sciences, Peking University, Beijing 100871, China
    FEBS Lett 582:1766-70. 2008
    The Drosophila mats gene plays a critical role in growth control. Using molecular genetic approaches we investigated how mats is regulated in development...
  37. pmc piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning
    Oren Schuldiner
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Dev Cell 14:227-38. 2008
    ..We also demonstrate a postmitotic role for SMC1 in dendrite targeting of olfactory projection neurons. We suggest that cohesin regulates diverse aspects of neuronal morphogenesis...
  38. pmc The mob as tumor suppressor gene is essential for early development and regulates tissue growth in Drosophila
    Takeshi Shimizu
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 178:957-65. 2008
    ..Expanded (Ex), Hippo (Hpo), Salvador (Sav)/Shar-pei, Warts (Wts)/Large tumor suppressor (Lats), and Mob as tumor suppressor (Mats), which are all evolutionarily conserved in vertebrate animals...
  39. ncbi Genes of Hippo signaling network act unconventionally in the control of germline proliferation in Drosophila
    Shuguo Sun
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, P R China
    Dev Dyn 237:270-5. 2008
    ..Furthermore, we demonstrate that expanded functions nonautonomously to regulate spermatogonial proliferation. It appears that expanded acts from the somatic support cells surrounding the germline to restrict spermatogonial amplification...
  40. pmc A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation
    Laurent Menut
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Genetics 177:1667-77. 2007
    ..The isolation of additional loci that affect hyperplastic as well as neoplastic growth indicates the utility of this screening strategy for studying epithelial growth control...
  41. ncbi Growth regulation: a beginning for the hippo pathway
    Iswar K Hariharan
    Department of Molecular and Cell Biology, 361 LSA, University of California Berkeley, Berkeley, California 94720, USA
    Curr Biol 16:R1037-9. 2006
    ..A signaling pathway involving two protein kinases, Hippo and Warts, restricts the growth of imaginal discs in Drosophila. Four recent studies taken together show that the protocadherin Fat can regulate Warts in two different ways...
  42. ncbi Seeing in color--warts and all
    Joseph M Bateman
    Samuel Lunenfeld Research Institute, Toronto, Canada
    Dev Cell 9:441-2. 2005
    ..show that cell fate decisions needed for color vision are dependent on a bistable negative feedback loop between genes previously implicated in cell proliferation (warts) and growth (melted)...
  43. pmc Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases
    Ying He
    Department of Biology, Center for Morphogenesis and Regenerative Medicine and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Mol Biol Cell 16:4139-52. 2005
    ..Interestingly, the overgrowth tumor phenotype that results from mutations in Dmob1 (mats) was only seen in genetic mosaics and not when the entire animal was mutant...
  44. ncbi Drosophila models for cancer research
    Marcos Vidal
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Curr Opin Genet Dev 16:10-6. 2006
    ..In the future, Drosophila models can be extended beyond basic research in the search for human therapeutics...

Research Grants2

  1. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
    ....
  2. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. [unreadable] [unreadable]..