Gene Symbol: Madm
Description: MLF1-adaptor molecule
Alias: BcDNA:LD28657, CG1098, Dmel\CG1098, MADM, anon-WO0118547.406, dMADM, lincRNA.S6031, MLF1-adaptor molecule, CG1098-PA, CG1098-PB, Madm-PA, Madm-PB, Mif1 adaptor molecule
Species: fruit fly
Lim R, Winteringham L, Williams J, McCulloch R, Ingley E, Tiao J, et al
. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. J Biol Chem. 2002;277:40997-1008 pubmed
..Two proteins isolated in this screen were 14-3-3zeta and a novel adaptor, Madm. Mlf1 contains a classic RSXSXP sequence for 14-3-3 binding and is associated with 14-3-3zeta via this ..
Singh S, Liu Y, Zhao J, Zeng X, Hou S. The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis. Nat Commun. 2016;7:10473 pubmed publisher
..However, little is known about the underlying molecular mechanism. Here we identify Mlf1-adaptor molecule (Madm), a novel tumour suppressor that regulates the competition between germline stem cells (GSCs) and somatic cyst stem ..
Anamika K, Abhinandan K, Deshmukh K, Srinivasan N. Classification of nonenzymatic homologues of protein kinases. Comp Funct Genomics. 2009;:365637 pubmed publisher
..The current classification scheme hopes to provide a convenient framework to classify the PKLNKs from other eukaryotes which would be helpful in deciphering their roles in cellular processes. ..
Gluderer S, Brunner E, Germann M, Jovaisaite V, Li C, Rentsch C, et al
. Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila. J Biol. 2010;9:9 pubmed publisher
..b>Madm (Mlf1 adapter molecule) physically associates with BunA via a conserved motif that is only contained in long ..
Tatomer D, Rizzardi L, Curry K, Witkowski A, Marzluff W, Duronio R. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Nucleus. 2014;5:613-25 pubmed publisher
..This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions. ..
Nie Y, Li Q, Amcheslavsky A, Duhart J, Veraksa A, Stocker H, et al
. Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila. Stem Cell Rev. 2015;11:813-25 pubmed publisher
..We show here that the leucine zipper protein Bunched and the adaptor protein Madm are novel regulators of intestinal stem cells...
Li X, Chatterjee N, Spirohn K, Boutros M, Bohmann D. Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes. Sci Rep. 2016;6:21455 pubmed publisher
..We suggest that Cdk12 acts as a gene-selective Pol II kinase that engages a global shift in gene expression to switch cells from a metabolically active state to "stress-defence mode" when challenged by external stress. ..