lysosomal enzyme receptor protein


Gene Symbol: lysosomal enzyme receptor protein
Description: lysosomal enzyme receptor protein
Alias: CG14255, CG14256, CG31072, CG6390, CG6396, Dmel\CG31072, LERP, anon-WO0118547.383, lysosomal enzyme receptor protein, CG31072-PA, CG31072-PB, CG31072-PD, CG31072-PE, Lerp-PA, Lerp-PB, Lerp-PD, Lerp-PE
Species: fruit fly

Top Publications

  1. Dennes A, Cromme C, Suresh K, Kumar N, Eble J, Hahnenkamp A, et al. The novel Drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and Drosophila GGA adaptors. J Biol Chem. 2005;280:12849-57 pubmed
    ..We identified the novel type I transmembrane protein lysosomal enzyme receptor protein (LERP) with partial homology to the mammalian MPR300 encoded by Drosophila gene CG31072...
  2. Hirst J, Sahlender D, Choma M, Sinka R, Harbour M, Parkinson M, et al. Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells. Traffic. 2009;10:1696-710 pubmed
    ..into clathrin-coated vesicles (CCVs), and the cargo protein GFP-LERP (green fluorescent protein-lysosomal enzyme receptor protein) is lost from CCVs only when both adaptors are depleted...
  3. Kametaka S, Sawada N, Bonifacino J, Waguri S. Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster. J Cell Sci. 2010;123:460-71 pubmed publisher
    ..dGGA recognizes the cytoplasmic acidic-cluster-dileucine (ACLL) sorting signal of Lerp (lysosomal enzyme receptor protein), a homolog of mammalian mannose 6-phosphate receptors...
  4. Eissenberg J, Ilvarsonn A, Sly W, Waheed A, Krzyzanek V, Pohlmann R, et al. Drosophila GGA model: an ultimate gateway to GGA analysis. Traffic. 2011;12:1821-38 pubmed publisher
    ..role in vivo, we used Drosophila which has a single GGA and a single lysosomal sorting receptor, lysosomal enzyme receptor protein (LERP). Using RNAi knockdowns, we show that the Drosophila GGA is required for lysosomal sorting...
  5. Chung W, Agius P, Westholm J, Chen M, Okamura K, Robine N, et al. Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans. Genome Res. 2011;21:286-300 pubmed publisher
    ..elegans harboring eight distinct mirtrons. Altogether, we demonstrate that discovery of functional mirtrons, unlike canonical miRNAs, is amenable to computational methods independent of evolutionary constraint. ..
  6. Kowalewski Nimmerfall E, Schähs P, Maresch D, Rendic D, KRAMER H, Mach L. Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development. Biochim Biophys Acta. 2014;1843:2900-12 pubmed publisher
    ..Furthermore, depletion of the putative D. melanogaster lysosomal sorting receptor lysosomal enzyme receptor protein did not compromise cellular retention of dCREG...
  7. Meadows L, Chan Y, Roote J, Russell S. Neighbourhood continuity is not required for correct testis gene expression in Drosophila. PLoS Biol. 2010;8:e1000552 pubmed publisher
    ..Our study challenges the notion that, at least in the case of the testis, expression neighbourhoods are a feature of eukaryotic genome organisation necessary for correct gene expression. ..
  8. Hirst J, Carmichael J. A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis. BMC Cell Biol. 2011;12:22 pubmed publisher
  9. Kametaka S, Kametaka A, Yonekura S, Haruta M, Takenoshita S, Goto S, et al. AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. J Cell Sci. 2012;125:634-48 pubmed publisher
    ..These results suggest that AP-1 and Aftiphilin are cooperatively involved in the intracellular trafficking of Notch during eye development in Drosophila. ..

More Information


  1. Burgess J, Del Bel L, Ma C, Barylko B, Polevoy G, Rollins J, et al. Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila. Development. 2012;139:3040-50 pubmed publisher
    ..and for formation of tubular endosomes that are likely to be involved in retrieving Snap24 and Lysosomal enzyme receptor protein (Lerp) from late endosomes to the trans-Golgi network...
  2. Maruzs T, Lőrincz P, Szatmári Z, Széplaki S, Sándor Z, Lakatos Z, et al. Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila. Traffic. 2015;16:1088-107 pubmed publisher
    ..Accordingly, we show that retromer is required for proper cathepsin L trafficking mainly independent of LERP, the Drosophila homolog of the cation-independent mannose 6-phosphate receptor...
  3. Hasanagic M, van Meel E, Luan S, Aurora R, Kornfeld S, Eissenberg J. The lysosomal enzyme receptor protein (LERP) is not essential, but is implicated in lysosomal function in Drosophila melanogaster. Biol Open. 2015;4:1316-25 pubmed publisher
    The lysosomal enzyme receptor protein (LERP) of Drosophila melanogaster is the ortholog of the mammalian cation-independent mannose 6-phosphate (Man 6-P) receptor, which mediates trafficking of newly synthesized lysosomal acid hydrolases ..