lsn

Summary

Gene Symbol: lsn
Description: larsen
Alias: CG6637, Dmel\CG6637, Lsn, Vps22, vps22, larsen, CG6637-PA, lsn-PA
Species: fruit fly

Top Publications

  1. Woodfield S, Graves H, Hernandez J, Bergmann A. De-regulation of JNK and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to neoplastic tumorigenesis. PLoS ONE. 2013;8:e56021 pubmed publisher
    ..including Endosomal Sorting Complex Required for Transport-II (ESCRT-II) components vacuolar protein sorting 22 (vps22), vps25, and vps36...
  2. Irion U, St Johnston D. bicoid RNA localization requires specific binding of an endosomal sorting complex. Nature. 2007;445:554-8 pubmed
    ..Here we show that mutants in all subunits of the ESCRT-II complex (VPS22, VPS25 and VPS36) abolish the final Staufen-dependent step in bicoid mRNA localization...
  3. Herz H, Woodfield S, Chen Z, Bolduc C, Bergmann A. Common and distinct genetic properties of ESCRT-II components in Drosophila. PLoS ONE. 2009;4:e4165 pubmed publisher
    ..Here, we genetically characterize the remaining ESCRT-II components vps22 and vps36...
  4. Vaccari T, Rusten T, Menut L, Nezis I, Brech A, Stenmark H, et al. Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci. 2009;122:2413-23 pubmed publisher
  5. Michelet X, Djeddi A, Legouis R. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Biol Cell. 2010;102:191-202 pubmed publisher
    ..The present review summarizes recent research on the developmental and cellular functions of the ESCRT in Caenorhabditis elegans, Drosophila melanogaster, Mus musculus or Arabidopsis thaliana. ..
  6. Zhang J, Du J, Lei C, Liu M, Zhu A. Ubpy controls the stability of the ESCRT-0 subunit Hrs in development. Development. 2014;141:1473-9 pubmed publisher
    ..Together, our data support a model in which Ubpy plays a dual role in both cargo deubiquitylation and the ESCRT-0 stability during development. ..
  7. Mattissek C, Teis D. The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis. Mol Membr Biol. 2014;31:111-9 pubmed publisher
    ..Therefore the aim of this review is to provide an overview on different model systems used to study the role of the ESCRT machinery in cancer development, to highlight common grounds and present certain controversies in the field. ..
  8. Gradilla A, González E, Seijo I, Andrés G, Bischoff M, González Mendez L, et al. Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion. Nat Commun. 2014;5:5649 pubmed publisher
    ..We propose Hh transport via exosomes along cytonemes as a significant mechanism for the restricted distribution of a lipid-modified morphogen. ..
  9. Vaccari T, Duchi S, Cortese K, Tacchetti C, Bilder D. The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development. 2010;137:1825-32 pubmed publisher
    ..The results also suggest that the ionic properties of the endosomal lumen might regulate Notch cleavage, providing a rationale for physiological as well as pathological endocytic control of Notch activity. ..

More Information

Publications14

  1. Yang X, Mao F, Lv X, Zhang Z, Fu L, Lu Y, et al. Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. J Cell Sci. 2013;126:4230-8 pubmed publisher
  2. Matusek T, Wendler F, Polès S, Pizette S, D Angelo G, Fürthauer M, et al. The ESCRT machinery regulates the secretion and long-range activity of Hedgehog. Nature. 2014;516:99-103 pubmed publisher
  3. Loncle N, Agromayor M, Martin Serrano J, Williams D. An ESCRT module is required for neuron pruning. Sci Rep. 2015;5:8461 pubmed publisher
    ..Furthermore we show that this ESCRT module requires a direct, in vivo, interaction between Shrub/CHMP4B and the accessory protein Myopic/HD-PTP. ..
  4. Dolezal D, Liu Z, Zhou Q, Pignoni F. Fly LMBR1/LIMR-type protein Lilipod promotes germ-line stem cell self-renewal by enhancing BMP signaling. Proc Natl Acad Sci U S A. 2015;112:13928-33 pubmed publisher
  5. Sheng Z, Yu L, Zhang T, Pei X, Li X, Zhang Z, et al. ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling. J Cell Sci. 2016;129:2075-84 pubmed publisher
    ..Because ESCRT-0 also plays crucial roles in EGFR downregulation after ligand binding, this study provides new insights into how loss of ESCRT-0 function can either increase or decrease EGFR signaling. ..