Gene Symbol: Lsm11
Description: Lsm11
Alias: CG12924, Dmel\CG12924, LSM11, dLsm11, Lsm11, CG12924-PA, Lsm11-PA
Species: fruit fly

Top Publications

  1. Liu J, Murphy C, Buszczak M, Clatterbuck S, Goodman R, Gall J. The Drosophila melanogaster Cajal body. J Cell Biol. 2006;172:875-84 pubmed
    ..melanogaster. The identification of these nuclear bodies now permits a broad range of questions to be asked about CB structure and function in a genetically tractable organism. ..
  2. Azzouz T, Schumperli D. Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster. RNA. 2003;9:1532-41 pubmed
    ..studies in Drosophila S2 cells indicate that the Drosophila Lsm10 and Lsm11 orthologs (dLsm10 and dLsm11) associate with each other and with Sm B, but not with Sm D1 and D2...
  3. Liu J, Gall J. U bodies are cytoplasmic structures that contain uridine-rich small nuclear ribonucleoproteins and associate with P bodies. Proc Natl Acad Sci U S A. 2007;104:11655-9 pubmed
    ..The identification of U bodies provides an opportunity to correlate specific biochemical steps of snRNP biogenesis with structural features of the cytoplasm. ..
  4. Weidmann C, Raynard N, Blewett N, Van Etten J, Goldstrohm A. The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation. RNA. 2014;20:1298-319 pubmed publisher
    ..Thus, the conserved function of the PUF RBD is to bind specific mRNAs, antagonize pAbp function, and promote deadenylation. ..
  5. Szakmary A, Reedy M, Qi H, Lin H. The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. J Cell Biol. 2009;185:613-27 pubmed publisher
    ..The entire Yb protein is necessary for piwi expression in niche cells. A double mutant of Yb and a novel locus show male germline loss, revealing a function for Yb in male germline stem cell maintenance. ..
  6. Sullivan K, Steiniger M, Marzluff W. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Mol Cell. 2009;34:322-32 pubmed publisher
    ..These results suggest that a common core cleavage factor is required for processing of histone and polyadenylated pre-mRNAs. ..
  7. Daneshvar K, Khan A, Goodliffe J. Myc localizes to histone locus bodies during replication in Drosophila. PLoS ONE. 2011;6:e23928 pubmed publisher
    ..Using antibodies specific for U7 snRNP component Lsm11, we show that the majority of Myc and coilin co-localization occurs in Histone Locus Bodies (HLBs), the sites of ..
  8. White A, Leslie M, Calvi B, Marzluff W, Duronio R. Developmental and cell cycle regulation of the Drosophila histone locus body. Mol Biol Cell. 2007;18:2491-502 pubmed
    ..nuclear structure associated with the histone locus and enriched in histone pre-mRNA processing factors such as Lsm11, a core component of the U7 small nuclear ribonucleoprotein...
  9. Burch B, Godfrey A, Gasdaska P, Salzler H, Duronio R, Marzluff W, et al. Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila. RNA. 2011;17:1132-47 pubmed publisher
    ..Here, we identify sequences in Drosophila FLASH (dFLASH) that bind Drosophila Lsm11 (dLsm11), allow localization of dFLASH to the nucleus and histone locus body (HLB), and participate in histone pre-mRNA ..

More Information


  1. Cauchi R, Sanchez Pulido L, Liu J. Drosophila SMN complex proteins Gemin2, Gemin3, and Gemin5 are components of U bodies. Exp Cell Res. 2010;316:2354-64 pubmed publisher
    ..In addition to a role in snRNP biogenesis, SMN complexes residing in U bodies may also be involved in mRNP assembly and/or transport. ..
  2. Salzler H, Tatomer D, Malek P, McDaniel S, Orlando A, Marzluff W, et al. A sequence in the Drosophila H3-H4 Promoter triggers histone locus body assembly and biosynthesis of replication-coupled histone mRNAs. Dev Cell. 2013;24:623-34 pubmed publisher
    ..We conclude that HLB assembly occurs through a stepwise process involving stochastic interactions of individual components that localize to a specific sequence in the H3-H4 promoter. ..
  3. Godfrey A, White A, Tatomer D, Marzluff W, Duronio R. The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development. RNA. 2009;15:1661-72 pubmed publisher
    ..U7 snRNP contains two like-Sm proteins, Lsm10 and Lsm11, which replace SmD1 and SmD2 in the canonical heptameric Sm protein ring that binds spliceosomal snRNAs...
  4. Yang X, Burch B, Yan Y, Marzluff W, Dominski Z. FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs. Mol Cell. 2009;36:267-78 pubmed publisher
    ..U7 snRNP contains a unique Sm ring in which the canonical SmD2 protein is replaced by Lsm11. We used the yeast two-hybrid system to identify binding partners of Lsm11 and selected the proapoptotic protein ..
  5. Bulchand S, Menon S, George S, Chia W. Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. J Cell Sci. 2010;123:2697-707 pubmed publisher
    ..a genetic interaction between mute and the Stem-loop binding protein (Slbp) and a loss of muscle striations in Lsm11 mutants...
  6. Guglielmi B, La Rochelle N, Tjian R. Gene-specific transcriptional mechanisms at the histone gene cluster revealed by single-cell imaging. Mol Cell. 2013;51:480-92 pubmed publisher
    ..These results provide mechanistic insights for the role of gene-specific core promoter factors and implications for cell cycle-regulated gene expression. ..
  7. Kotova E, Jarnik M, Tulin A. Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. PLoS Genet. 2009;5:e1000387 pubmed publisher
  8. Fichelson P, Moch C, Ivanovitch K, Martin C, Sidor C, Lepesant J, et al. Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila. Nat Cell Biol. 2009;11:685-93 pubmed publisher
    ..In the absence of Wcd, NSCs became smaller and produced fewer neurons. Our results show that regulation of ribosome synthesis is a crucial parameter for stem cell maintenance and function. ..
  9. Beumer K, Trautman J, Bozas A, Liu J, Rutter J, Gall J, et al. Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases. Proc Natl Acad Sci U S A. 2008;105:19821-6 pubmed publisher
    ..The injection procedure is much more rapid than earlier approaches and makes possible the generation and recovery of targeted gene alterations at essentially any locus within 2 fly generations. ..