Gene Symbol: Lsd-1
Description: Lipid storage droplet-1
Alias: CG10374, DmPLIN1, Dmel\CG10374, LSD-1, LSDP1, Lsd1, Lsdp1, PLIN1, lsd1, plin1, lipid storage droplet-1, CG10374-PA, CG10374-PB, CG10374-PC, CG10374-PD, Lsd-1-PA, Lsd-1-PB, Lsd-1-PC, Lsd-1-PD, lipid storage droplet protein 1, lipid storage droplets surface binding protein, perilipin
Species: fruit fly

Top Publications

  1. Mulligan P, Yang F, Di Stefano L, Ji J, Ouyang J, Nishikawa J, et al. A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell. 2011;42:689-99 pubmed publisher
    ..We describe here a SIRT1 corepressor complex containing the histone H3K4 demethylase LSD1/KDM1A and several other LSD1-associated proteins...
  2. Men T, Binh T, Yamaguchi M, Huy N, Kamei K. Function of Lipid Storage Droplet 1 (Lsd1) in Wing Development of Drosophila melanogaster. Int J Mol Sci. 2016;17: pubmed publisher
    Perilipins are evolutionarily conserved from Drosophila to humans, the lipid storage droplet 1 (Lsd1) is a Drosophila homolog of human perilipin 1...
  3. Arrese E, Rivera L, Hamada M, Soulages J. Purification and characterization of recombinant lipid storage protein-2 from Drosophila melanogaster. Protein Pept Lett. 2008;15:1027-32 pubmed
    ..This study provides the starting point for future studies on the mechanism of function of Lsd2. The similarities and differences between Lsd1 and Lsd2, the only PAT proteins found in insects, are discussed.
  4. Tian Y, Bi J, Shui G, Liu Z, Xiang Y, Liu Y, et al. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. PLoS Genet. 2011;7:e1001364 pubmed publisher
    ..In summary, we have demonstrated a tissue-autonomous role of dSeipin in ectopic lipid storage in lipodystrophy. ..
  5. Bi J, Xiang Y, Chen H, Liu Z, Gronke S, Kühnlein R, et al. Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization. J Cell Sci. 2012;125:3568-77 pubmed
    ..Mammals have five perilipin proteins, which often exhibit redundant functions, precluding the analysis of the exact role of individual ..
  6. Lee H, Peng Y, Guo Y. Analysis of lipid droplet dynamics and functions in Drosophila melanogaster. Methods Cell Biol. 2013;116:53-69 pubmed publisher
  7. Lin P, Chen X, Moktan H, Arrese E, Duan L, Wang L, et al. Membrane attachment and structure models of lipid storage droplet protein 1. Biochim Biophys Acta. 2014;1838:874-81 pubmed publisher
    ..are actively regulated by several proteins specific to the droplet surface, one of which in insects is PLIN1. PLIN1 plays a key role in the activation of triglyceride hydrolysis upon phosphorylation...
  8. Miles W, Lepesant J, Bourdeaux J, Texier M, Kerenyi M, Nakakido M, et al. The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop. Mol Cell Biol. 2015;35:4199-211 pubmed publisher
    The lysine (K)-specific demethylase (LSD1) family of histone demethylases regulates chromatin structure and the transcriptional potential of genes...
  9. Miura S, Gan J, Brzostowski J, Parisi M, Schultz C, Londos C, et al. Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J Biol Chem. 2002;277:32253-7 pubmed
    ..The mammalian proteins Perilipin, ADRP, and TIP47 share extensive amino acid sequence similarity, suggesting a common function...

More Information


  1. Beller M, Bulankina A, Hsiao H, Urlaub H, Jackle H, Kühnlein R. PERILIPIN-dependent control of lipid droplet structure and fat storage in Drosophila. Cell Metab. 2010;12:521-32 pubmed publisher
    ..In mammals, members of the evolutionarily conserved PERILIPIN protein family are associated with the lipid droplet surface and participate in lipid homeostasis...
  2. Eliazer S, Palacios V, Wang Z, Kollipara R, Kittler R, Buszczak M. Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells. PLoS Genet. 2014;10:e1004200 pubmed publisher
    ..Loss of the highly conserved histone demethylase Lsd1 in Drosophila escort cells results in increased BMP signaling outside the cap cell niche and an expanded germline ..
  3. Tsuda Sakurai K, Seong K, Horiuchi J, Aigaki T, Tsuda M. Identification of a novel role for Drosophila MESR4 in lipid metabolism. Genes Cells. 2015;20:358-65 pubmed publisher
    ..These results suggest that MESR4 acts as an important upstream regulator of energy homeostasis. ..
  4. Arrese E, Rivera L, Hamada M, Mirza S, Hartson S, Weintraub S, et al. Function and structure of lipid storage droplet protein 1 studied in lipoprotein complexes. Arch Biochem Biophys. 2008;473:42-7 pubmed publisher
    ..Several proteins surrounding the LDs have been implicated in TG homeostasis such as mammalian perilipin A and insect lipid storage proteins (Lsd)...
  5. Thiel K, Heier C, Haberl V, Thul P, Oberer M, Lass A, et al. The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage. J Cell Sci. 2013;126:2198-212 pubmed publisher
    ..The results indicate that we identified the first members of a novel and evolutionarily conserved family of lipid storage regulators, which are also required to properly position LDs within cells. ..