Gene Symbol: loco
Description: locomotion defects
Alias: CG17229, CG5248, Dmel\CG5248, LOCO, Loco, dLoco, locomotion defects, CG5248-PB, CG5248-PC, CG5248-PD, CG5248-PF, CG5248-PH, loco-PB, loco-PC, loco-PD, loco-PF, loco-PH, locomotion defect
Species: fruit fly

Top Publications

  1. Kaplow M, Korayem A, Venkatesh T. Regulation of glia number in Drosophila by Rap/Fzr, an activator of the anaphase-promoting complex, and Loco, an RGS protein. Genetics. 2008;178:2003-16 pubmed publisher
    ..and biochemical data further indicate that Rap/Fzr regulates glial differentiation through its interaction with Loco, a regulator of G-protein signaling (RGS) protein and a known effector of glia specification...
  2. Yu F, Wang H, Qian H, Kaushik R, Bownes M, Yang X, et al. Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions. Genes Dev. 2005;19:1341-53 pubmed
    ..However, how Gbetagamma is released from the inactive heterotrimer remains unclear. Here we show that Locomotion defects (Loco) interacts and colocalizes with Galphai and, through its GoLoco motif, acts as a guanine nucleotide ..
  3. Pathirana S, Zhao D, Bownes M. The Drosophila RGS protein Loco is required for dorsal/ventral axis formation of the egg and embryo, and nurse cell dumping. Mech Dev. 2001;109:137-50 pubmed
    The loco gene encodes members of a family of RGS proteins responsible for the negative regulation of G-protein signalling...
  4. Granderath S, Klämbt C. Identification and functional analysis of the Drosophila gene loco. Methods Enzymol. 2004;389:350-63 pubmed
    ..The best-studied RGS gene in Drosophila is loco, a member of the D/R12 subfamily. The four different protein isoforms all contain RGS, GoLoco, and RBD domains...
  5. Granderath S, Stollewerk A, Greig S, Goodman C, O Kane C, Klämbt C. loco encodes an RGS protein required for Drosophila glial differentiation. Development. 1999;126:1781-91 pubmed
    ..Using an enhancer trap approach, we have identified loco as such a gene. loco is expressed in most lateral CNS glial cells throughout development...
  6. Katanaev V, Tomlinson A. Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila. Proc Natl Acad Sci U S A. 2006;103:6524-9 pubmed
    ..Thus, Go likely integrates the signaling that directs the formation of the complex with the signaling that directs where the complex forms. ..
  7. Jhaveri D, Saharan S, Sen A, Rodrigues V. Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling. Development. 2004;131:1903-12 pubmed
    ..The location of sensory arbors at distinct positions within the lobe allows short-range interactions with projection neurons leading to formation of the glomeruli. ..
  8. Küppers Munther B, Letzkus J, Lüer K, Technau G, Schmidt H, Prokop A. A new culturing strategy optimises Drosophila primary cell cultures for structural and functional analyses. Dev Biol. 2004;269:459-78 pubmed
  9. Thomas G, van Meyel D. The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression. Development. 2007;134:591-600 pubmed

More Information


  1. Daneman R, Barres B. The blood-brain barrier--lessons from moody flies. Cell. 2005;123:9-12 pubmed
    ..Meanwhile, moody also has been identified in a screen for fly mutants with altered sensitivity to cocaine, remarkably implicating the BBB in the physiological response to narcotics. ..
  2. Dembeck L, Huang W, Magwire M, Lawrence F, Lyman R, Mackay T. Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster. PLoS Genet. 2015;11:e1005163 pubmed publisher
    ..Variation in these novel candidates may serve as targets for adaptive evolution and sexual selection in D. melanogaster. ..
  3. Tschäpe J, Hammerschmied C, Mühlig Versen M, Athenstaedt K, Daum G, Kretzschmar D. The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing. EMBO J. 2002;21:6367-76 pubmed
    ..These results describe a novel function of AMPK in neurodegeneration and APPL/APP processing which could be mediated through HMG-CoA reductase and cholesterol ester. ..
  4. Lin Y, Parikh H, Park Y. Loco signaling pathway in longevity. Small Gtpases. 2011;2:158-161 pubmed
    ..We found that reduced expression of Loco, a Drosophila RGS protein, resulted in a longer lifespan of flies with stronger resistance to stress, higher MnSOD ..
  5. Edenfeld G, Volohonsky G, Krukkert K, Naffin E, Lammel U, Grimm A, et al. The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in Drosophila. Neuron. 2006;52:969-80 pubmed
  6. Tayler T, Robichaux M, Garrity P. Compartmentalization of visual centers in the Drosophila brain requires Slit and Robo proteins. Development. 2004;131:5935-45 pubmed
    ..We propose that Slit and Robo-family proteins act to maintain the distinct cellular composition of the lamina and the lobula cortex. ..
  7. Jones B. Glial cell development in the Drosophila embryo. Bioessays. 2001;23:877-87 pubmed
    ..Other roles of glia are being explored, including their requirement for axon guidance, neuronal survival, and signaling. ..
  8. Schwabe T, Bainton R, Fetter R, Heberlein U, Gaul U. GPCR signaling is required for blood-brain barrier formation in drosophila. Cell. 2005;123:133-44 pubmed
    ..receptor (GPCR) Moody, the G protein subunits G alpha i and G alpha o, and the regulator of G protein signaling Loco are required in the surface glia to achieve effective insulation...
  9. Kopein D, Katanaev V. Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling. Mol Biol Cell. 2009;20:3865-77 pubmed publisher
    ..g., in the context of the nervous system development, where Galpha(o) acts downstream from Frizzled and redundantly with Galpha(i) to control the asymmetry of cell divisions. ..
  10. Lin C, Koval A, Tishchenko S, Gabdulkhakov A, Tin U, Solis G, et al. Double suppression of the G? protein activity by RGS proteins. Mol Cell. 2014;53:663-71 pubmed publisher
    ..Our studies identify Dhit and its homologs as double-action regulators, inhibiting G?o/i proteins both through suppression of their activation and acceleration of their inactivation through the single RGS domain. ..
  11. McGurk L, Pathirana S, Rothwell K, Trimbuch T, Colombini P, Yu F, et al. The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster. BMC Dev Biol. 2008;8:37 pubmed publisher
    The loco gene encodes several different isoforms of a regulator of G-protein signalling. These different isoforms of LOCO are part of a pathway enabling cells to respond to external signals...
  12. Jin L, Shim J, Yoon J, Kim B, Kim J, Kim Ha J, et al. Identification and functional analysis of antifungal immune response genes in Drosophila. PLoS Pathog. 2008;4:e1000168 pubmed publisher
    ..Our results identify a new class of genes involved in antifungal immune responses in Drosophila. ..
  13. Lin Y, Kim K, Yang Y, Ivessa A, Sadoshima J, Park Y. Regulation of longevity by regulator of G-protein signaling protein, Loco. Aging Cell. 2011;10:438-47 pubmed publisher
    ..Reduced expression of Loco, a RGS protein of Drosophila melanogaster, resulted in a longer lifespan for both male and female flies, also ..
  14. Jones B. Transcriptional control of glial cell development in Drosophila. Dev Biol. 2005;278:265-73 pubmed
  15. Granderath S, Bunse I, Klämbt C. gcm and pointed synergistically control glial transcription of the Drosophila gene loco. Mech Dev. 2000;91:197-208 pubmed
    ..The gene loco has been identified as a potential target gene of pointed and is involved in terminal glial differentiation...