Gene Symbol: lmgA
Description: lemming A
Alias: APC11, Apc11, CG18042, CG34440, Dmel\CG34440, Dmel_CG18042, Dromel_CG18042_FBtr0079695_lmg_uORF, Img, LMG, ORF1, l(2)03424, lmg, lemming A, CG34440-PA, CG34440-PB, CG34440-PC, CG34440-PD, lemming, lmgA-PA, lmgA-PB, lmgA-PC, lmgA-PD
Species: fruit fly

Top Publications

  1. Buttitta L, Katzaroff A, Edgar B. A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. J Cell Biol. 2010;189:981-96 pubmed publisher
    ..These mechanisms are essential for proper development, as evading them leads to tissue outgrowths composed of dividing but terminally differentiated cells. ..
  2. Mohd Sarip A, Lagarou A, Doyen C, van der Knaap J, Aslan U, Bezstarosti K, et al. Transcription-independent function of Polycomb group protein PSC in cell cycle control. Science. 2012;336:744-7 pubmed publisher
    ..Cell-based experiments and reconstituted reactions established that PSC and Lemming (LMG, also called APC11) associate and ubiquitylate CYC-B cooperatively, marking it for proteosomal degradation...
  3. Bocca S, Muzzopappa M, Silberstein S, Wappner P. Occurrence of a putative SCF ubiquitin ligase complex in Drosophila. Biochem Biophys Res Commun. 2001;286:357-64 pubmed
    ..Our results suggest that dRbx1, dSkpA, dCullin1, and Slimb proteins are components of a Drosophila SCF complex that functions in combination with the ubiquitin conjugating enzyme UbcD1. ..
  4. Kuo C, Zhu S, Younger S, Jan L, Jan Y. Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron. 2006;51:283-90 pubmed
    ..Thus, in addition to uncovering E2/E3 ubiquitinating enzymes for dendrite pruning, this study provides a mechanistic link between UPS and the apoptotic machinery in regulating neuronal process remodeling. ..
  5. Silies M, Klämbt C. APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS. Nat Neurosci. 2010;13:1357-64 pubmed publisher
    ..This represents a simple mechanism by which a subcellular gradient of adhesiveness can coordinate glial migration with axonal growth...
  6. Taylor C, Stanley K, Shirras A. The Orct gene of Drosophila melanogaster codes for a putative organic cation transporter with six or 12 transmembrane domains. Gene. 1997;201:69-74 pubmed
    Mutations at the lemming (lmg) locus of Drosophila melanogaster cause apoptotic cell death in dividing imaginal cells...
  7. Harper J, Burton J, Solomon M. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 2002;16:2179-206 pubmed
  8. Watts R, Hoopfer E, Luo L. Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron. 2003;38:871-85 pubmed
    ..Our findings suggest that some forms of axon pruning during development may share similarities with degeneration of axons in response to injury. ..
  9. Nagy O, Pal M, Udvardy A, Shirras C, Boros I, Shirras A, et al. lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2. Cell Div. 2012;7:9 pubmed publisher
    ..Here, lemming (lmg) mutants were used to study the APC/C subunit, Apc11, and its interaction partners in Drosophila ..

More Information


  1. Acquaviva C, Pines J. The anaphase-promoting complex/cyclosome: APC/C. J Cell Sci. 2006;119:2401-4 pubmed