Lip4

Summary

Gene Symbol: Lip4
Description: Lipase 4
Alias: CG6113, Dmel\CG6113, dLip4, dlip4, lip4, lipase 4, CG6113-PA, CG6113-PB, CG6113-PC, Lip4-PA, Lip4-PB, Lip4-PC, lipase4
Species: fruit fly

Top Publications

  1. Vihervaara T, Puig O. dFOXO regulates transcription of a Drosophila acid lipase. J Mol Biol. 2008;376:1215-23 pubmed publisher
    ..Here, we show that in flies, dFOXO regulates lipase 4 (dLip4), a Drosophila homologue of human acid lipases...
  2. Cryderman D, Grade S, Li Y, Fanti L, Pimpinelli S, Wallrath L. Role of Drosophila HP1 in euchromatic gene expression. Dev Dyn. 2005;232:767-74 pubmed
    ..Collectively, these data demonstrate multiple mechanisms for HP1 localization within euchromatin and show that some genes associated with HP1 are not affected by alterations in Su(var)3-9 dosage. ..
  3. Karpac J, Hull Thompson J, Falleur M, Jasper H. JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell. 2009;8:288-95 pubmed publisher
    ..Endocrine control of IIS by JNK in IPCs is thus critical for systemic adaptation to stress. ..
  4. Chen K, Lin G, Haelterman N, Ho T, Li T, Li Z, et al. Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. elife. 2016;5: pubmed publisher
    ..Our results indicate that an iron/sphingolipid/Pdk1/Mef2 pathway may play a role in FRDA. ..
  5. Hull Thompson J, Muffat J, Sanchez D, Walker D, Benzer S, Ganfornina M, et al. Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz. PLoS Genet. 2009;5:e1000460 pubmed publisher
    ..The JNK pathway and Lipocalins are structurally and functionally conserved, suggesting that similar interactions represent an evolutionarily conserved system for the control of metabolic homeostasis. ..
  6. Ballard S, Jarolimova J, Wharton K. Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila. Dev Biol. 2010;337:375-85 pubmed publisher
    ..Overall, our results implicate Gbb/BMP signaling as a new pathway critical for positive regulation of nutrient storage and energy homeostasis during development. ..
  7. Liu L, Zhang K, Sandoval H, Yamamoto S, Jaiswal M, Sanz E, et al. Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell. 2015;160:177-90 pubmed publisher
  8. Maynard J, Pham T, Zheng T, Jockheck Clark A, Rankin H, Newgard C, et al. Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Dev Biol. 2010;339:295-306 pubmed publisher
  9. Karpac J, Biteau B, Jasper H. Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila. Cell Rep. 2013;4:1250-61 pubmed publisher
    ..Changes in the regulation of Foxo-mediated adaptive responses thus contribute to the age-associated breakdown of metabolic homeostasis. ..

More Information

Publications10

  1. Ruiz M, Ganfornina M, Correnti C, Strong R, Sanchez D. Ligand binding-dependent functions of the lipocalin NLaz: an in vivo study in Drosophila. FASEB J. 2014;28:1555-67 pubmed publisher
    ..Control of energy metabolites on starvation appears to be, however, insensitive to the modification of the NLaz binding pocket. ..